Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans
Objective: Glucagon and glucagon-like peptide-1 (GLP-1) originate from the common precursor, proglucagon, and their plasma concentrations have been reported to be increased during inflammatory conditions. Increased blood glucose levels are frequently observed in septic patients, and therefore we hyp...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Bioscientifica
2021-03-01
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| Series: | Endocrine Connections |
| Subjects: | |
| Online Access: | https://ec.bioscientifica.com/view/journals/ec/10/2/EC-20-0590.xml |
| _version_ | 1818558120002060288 |
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| author | Justyna Modrzynska Christine F Klein Kasper Iversen Henning Bundgaard Bolette Hartmann Maike Mose Nikolaj Rittig Niels Møller Jens J Holst Nicolai J Wewer Albrechtsen |
| author_facet | Justyna Modrzynska Christine F Klein Kasper Iversen Henning Bundgaard Bolette Hartmann Maike Mose Nikolaj Rittig Niels Møller Jens J Holst Nicolai J Wewer Albrechtsen |
| author_sort | Justyna Modrzynska |
| collection | DOAJ |
| description | Objective: Glucagon and glucagon-like peptide-1 (GLP-1) originate from the common precursor, proglucagon, and their plasma concentrations have been reported to be increased during inflammatory conditions. Increased blood glucose levels are frequently observed in septic patients, and therefore we hypothesized that glucagon, but not GLP-1, is increased in individuals with inflammation.
Design: Prospective longitudinal cohort study.
Materials and methods: We measured glucagon and GLP-1 in plasma sampled consecutively in three cohorts consisting of patients with infective endocarditis (n = 16), urosepsis (n = 28) and post-operative inflammation following percutaneous aortic valve implantation or thoracic endovascular aortic repair (n = 5). Correlations between C-reactive protein (CRP), a marker of systemic inflammat ion, and glucagon and GLP-1 concentrations were investigated. Additionally, glucagon and GLP-1 concentrations were measured after a bolus infusion of lipopolysaccharide (LPS, 1 ng/kg) in nine healthy young males.
Results: Glucagon and CRP were positively and significantly correlated ( r = 0.27; P = 0.0003), whereas no significant association between GLP-1 and CRP was found (r = 0.08, P = 0.30). LPS infusion resulted in acute systemic inflammation reflected by increased temperature, pulse, tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and concomitantly increased concentrations of glucagon (P < 0.05) but not GLP-1.
Conclusions: Systemic inflammation caused by bacterial infections or develop ed as a non-infected condition is associated with increased plasma concentration of glucagon, but not GLP-1. Hyperglucagonemia may contribute to the impaired glucose control in patients with systemic inflammatory diseases. |
| first_indexed | 2024-12-14T00:08:35Z |
| format | Article |
| id | doaj.art-f1211a524b0c42eea2e21cde29bc7ea0 |
| institution | Directory Open Access Journal |
| issn | 2049-3614 2049-3614 |
| language | English |
| last_indexed | 2024-12-14T00:08:35Z |
| publishDate | 2021-03-01 |
| publisher | Bioscientifica |
| record_format | Article |
| series | Endocrine Connections |
| spelling | doaj.art-f1211a524b0c42eea2e21cde29bc7ea02022-12-21T23:25:52ZengBioscientificaEndocrine Connections2049-36142049-36142021-03-01102205213https://doi.org/10.1530/EC-20-0590Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humansJustyna Modrzynska0Christine F Klein1Kasper Iversen2Henning Bundgaard3Bolette Hartmann4Maike Mose5Nikolaj Rittig6Niels Møller7Jens J Holst8Nicolai J Wewer Albrechtsen9Department of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Cardiology, Herlev Gentofte Hospital, Herlev, DenmarkDepartment of Clinical Medicine, Herlev Gentofte Hospital, Herlev, DenmarkDepartment of Cardiology, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Endocrinology and Internal Medicine, Aarhus University Hospital, Aarhus, DenmarkSteno Diabetes Center Aarhus, Aarhus University Hospital, Aarhus, DenmarkDepartment of Clinical Medicine, Aarhus University Hospital, Aarhus, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Basic Metabolic Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, DenmarkDepartment of Biomedical Sciences, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Novo Nordisk Foundation Center for Protein Research, Faculty of Health and Medical Sciences, University of Copenhagen, Copenhagen, Denmark; Department of Clinical Biochemistry, Rigshospitalet, University of Copenhagen, Copenhagen, DenmarkObjective: Glucagon and glucagon-like peptide-1 (GLP-1) originate from the common precursor, proglucagon, and their plasma concentrations have been reported to be increased during inflammatory conditions. Increased blood glucose levels are frequently observed in septic patients, and therefore we hypothesized that glucagon, but not GLP-1, is increased in individuals with inflammation. Design: Prospective longitudinal cohort study. Materials and methods: We measured glucagon and GLP-1 in plasma sampled consecutively in three cohorts consisting of patients with infective endocarditis (n = 16), urosepsis (n = 28) and post-operative inflammation following percutaneous aortic valve implantation or thoracic endovascular aortic repair (n = 5). Correlations between C-reactive protein (CRP), a marker of systemic inflammat ion, and glucagon and GLP-1 concentrations were investigated. Additionally, glucagon and GLP-1 concentrations were measured after a bolus infusion of lipopolysaccharide (LPS, 1 ng/kg) in nine healthy young males. Results: Glucagon and CRP were positively and significantly correlated ( r = 0.27; P = 0.0003), whereas no significant association between GLP-1 and CRP was found (r = 0.08, P = 0.30). LPS infusion resulted in acute systemic inflammation reflected by increased temperature, pulse, tumor necrosis factor-α (TNFα), interleukin-6 (IL-6) and concomitantly increased concentrations of glucagon (P < 0.05) but not GLP-1. Conclusions: Systemic inflammation caused by bacterial infections or develop ed as a non-infected condition is associated with increased plasma concentration of glucagon, but not GLP-1. Hyperglucagonemia may contribute to the impaired glucose control in patients with systemic inflammatory diseases.https://ec.bioscientifica.com/view/journals/ec/10/2/EC-20-0590.xmlbacteremiaelisaglucosehyperglycemiaimmunoassayinfectioninflammation |
| spellingShingle | Justyna Modrzynska Christine F Klein Kasper Iversen Henning Bundgaard Bolette Hartmann Maike Mose Nikolaj Rittig Niels Møller Jens J Holst Nicolai J Wewer Albrechtsen Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans Endocrine Connections bacteremia elisa glucose hyperglycemia immunoassay infection inflammation |
| title | Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans |
| title_full | Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans |
| title_fullStr | Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans |
| title_full_unstemmed | Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans |
| title_short | Plasma levels of glucagon but not GLP-1 are elevated in response to inflammation in humans |
| title_sort | plasma levels of glucagon but not glp 1 are elevated in response to inflammation in humans |
| topic | bacteremia elisa glucose hyperglycemia immunoassay infection inflammation |
| url | https://ec.bioscientifica.com/view/journals/ec/10/2/EC-20-0590.xml |
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