Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment
We report results in a 77-year-old male patient with visual loss from long-standing serpiginous choroidopathy treated with bone marrow derived stem cells (BMSC) within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and the largest...
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| Format: | Article |
| Language: | English |
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Wolters Kluwer Medknow Publications
2016-01-01
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| Series: | Neural Regeneration Research |
| Subjects: | |
| Online Access: | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=9;spage=1512;epage=1516;aulast=Weiss |
| _version_ | 1818520120083873792 |
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| author | Jeffrey N Weiss Susan C Benes Steven Levy |
| author_facet | Jeffrey N Weiss Susan C Benes Steven Levy |
| author_sort | Jeffrey N Weiss |
| collection | DOAJ |
| description | We report results in a 77-year-old male patient with visual loss from long-standing serpiginous choroidopathy treated with bone marrow derived stem cells (BMSC) within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and the largest ophthalmology stem cell study registered at the National Institutes of Health to date (ClinicalTrials.gov Identifier: NCT01920867). Eight months after treatment by a combination of retrobulbar, subtenon, intravitreal and intravenous injection of BMSC, the patient′s best corrected Snellen acuity improved from 20/80 - to 20/60 +1 in the right eye and from 20/50 - to 20/20 -3 in the left eye. The Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity continued to improve over the succeeding 8 months and the optical coherence tomography macular volume increased. The increases in visual acuity and macular volume are encouraging and suggest that the use of BMSC as provided in SCOTS may be a viable approach to treating serpiginous choroidopathy. |
| first_indexed | 2024-12-11T01:33:07Z |
| format | Article |
| id | doaj.art-f1263abd7c394bdbae61dd9cafdde91f |
| institution | Directory Open Access Journal |
| issn | 1673-5374 |
| language | English |
| last_indexed | 2024-12-11T01:33:07Z |
| publishDate | 2016-01-01 |
| publisher | Wolters Kluwer Medknow Publications |
| record_format | Article |
| series | Neural Regeneration Research |
| spelling | doaj.art-f1263abd7c394bdbae61dd9cafdde91f2022-12-22T01:25:19ZengWolters Kluwer Medknow PublicationsNeural Regeneration Research1673-53742016-01-011191512151610.4103/1673-5374.191229Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatmentJeffrey N WeissSusan C BenesSteven LevyWe report results in a 77-year-old male patient with visual loss from long-standing serpiginous choroidopathy treated with bone marrow derived stem cells (BMSC) within the Stem Cell Ophthalmology Treatment Study (SCOTS). SCOTS is an Institutional Review Board approved clinical trial and the largest ophthalmology stem cell study registered at the National Institutes of Health to date (ClinicalTrials.gov Identifier: NCT01920867). Eight months after treatment by a combination of retrobulbar, subtenon, intravitreal and intravenous injection of BMSC, the patient′s best corrected Snellen acuity improved from 20/80 - to 20/60 +1 in the right eye and from 20/50 - to 20/20 -3 in the left eye. The Early Treatment of Diabetic Retinopathy Study (ETDRS) visual acuity continued to improve over the succeeding 8 months and the optical coherence tomography macular volume increased. The increases in visual acuity and macular volume are encouraging and suggest that the use of BMSC as provided in SCOTS may be a viable approach to treating serpiginous choroidopathy.http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=9;spage=1512;epage=1516;aulast=Weissserpiginous choroidopathy; serpigionous choroiditis; geographic helicoid peripapillary chroidopathy; retina; macula; stem cell therapy; uveitis |
| spellingShingle | Jeffrey N Weiss Susan C Benes Steven Levy Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment Neural Regeneration Research serpiginous choroidopathy; serpigionous choroiditis; geographic helicoid peripapillary chroidopathy; retina; macula; stem cell therapy; uveitis |
| title | Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| title_full | Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| title_fullStr | Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| title_full_unstemmed | Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| title_short | Stem Cell Ophthalmology Treatment Study (SCOTS): improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| title_sort | stem cell ophthalmology treatment study scots improvement in serpiginous choroidopathy following autologous bone marrow derived stem cell treatment |
| topic | serpiginous choroidopathy; serpigionous choroiditis; geographic helicoid peripapillary chroidopathy; retina; macula; stem cell therapy; uveitis |
| url | http://www.nrronline.org/article.asp?issn=1673-5374;year=2016;volume=11;issue=9;spage=1512;epage=1516;aulast=Weiss |
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