Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway

Ilicicolin A Exerts Antitumor Effect in Castration-Resistant Prostate Cancer Via Suppressing EZH2 Signaling Pathway

The Polycomb protein enhancer of zeste homolog 2 (EZH2) has critical roles in prostate cancer (PCa) progression and drug-resistance, which remains an obstacle for PCa treatment. Enzalutamide (ENZ) is a second-generation androgen receptor antagonist employed for treatment of metastatic castration-res...

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Bibliographic Details
Main Authors: Lang Guo, Xiaowei Luo, Ping Yang, Yanting Zhang, Jialuo Huang, Hong Wang, Yinfeng Guo, Weifeng Huang, Zhiqiang Chen, Shusheng Wang, Junjian Wang, Jinping Lei, Songtao Xiang, Yonghong Liu
Format: Article
Language:English
Published: Frontiers Media S.A. 2021-10-01
Series:Frontiers in Pharmacology
Subjects:
ascochlorin derivatives
enhancer of zeste homolog 2
enzalutamide
castration-resistant prostate cancer (CRPC)
androgen receptor
Online Access:https://www.frontiersin.org/articles/10.3389/fphar.2021.723729/full

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