Amnion: A Potent Graft Source for Cell Therapy in Stroke
Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and thes...
| Main Authors: | , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
SAGE Publishing
2009-02-01
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| Series: | Cell Transplantation |
| Online Access: | https://doi.org/10.3727/096368909788341243 |
| _version_ | 1818504884170784768 |
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| author | Seong Jin Yu Maddalena Soncini Yuji Kaneko David C. Hess Ornella Parolini Cesar V. Borlongan Ph.D. |
| author_facet | Seong Jin Yu Maddalena Soncini Yuji Kaneko David C. Hess Ornella Parolini Cesar V. Borlongan Ph.D. |
| author_sort | Seong Jin Yu |
| collection | DOAJ |
| description | Regenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a novel cell source for cell transplantation therapy. Cells isolated from amniotic membrane can differentiate into all three germ layers, have low immunogenicity and anti-inflammatory function, and do not require the destruction of human embryos for their isolation, thus circumventing the ethical debate commonly associated with the use of human embryonic stem cells. Accumulating evidence now suggests that the amnion, which had been discarded after parturition, is a highly potent transplant material in the field of regenerative medicine. In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke. |
| first_indexed | 2024-12-10T21:43:16Z |
| format | Article |
| id | doaj.art-f128f9b9e4ed452cb03d1aa3fb823bce |
| institution | Directory Open Access Journal |
| issn | 0963-6897 1555-3892 |
| language | English |
| last_indexed | 2024-12-10T21:43:16Z |
| publishDate | 2009-02-01 |
| publisher | SAGE Publishing |
| record_format | Article |
| series | Cell Transplantation |
| spelling | doaj.art-f128f9b9e4ed452cb03d1aa3fb823bce2022-12-22T01:32:26ZengSAGE PublishingCell Transplantation0963-68971555-38922009-02-011810.3727/096368909788341243Amnion: A Potent Graft Source for Cell Therapy in StrokeSeong Jin Yu0Maddalena Soncini1Yuji Kaneko2David C. Hess3Ornella Parolini4Cesar V. Borlongan Ph.D.5Department of Neurology, Medical College of Georgia, Augusta, GA, USACentro di Ricerca E. Menni, Fondazione Poliambulanza Instituto Ospedaliero, Brescia, ItalyDepartment of Neurology, Medical College of Georgia, Augusta, GA, USADepartment of Neurology, Medical College of Georgia, Augusta, GA, USACentro di Ricerca E. Menni, Fondazione Poliambulanza Instituto Ospedaliero, Brescia, ItalyInstitute of Molecular Medicine Genetics, Medical College of Georgia, Augusta, GA, USARegenerative medicine is a new field primarily based on the concept of transplanting exogenous or stimulating endogenous stem cells to generate biological substitutes and improve tissue functions. Recently, amnion-derived cells have been reported to have multipotent differentiation ability, and these cells have attracted attention as a novel cell source for cell transplantation therapy. Cells isolated from amniotic membrane can differentiate into all three germ layers, have low immunogenicity and anti-inflammatory function, and do not require the destruction of human embryos for their isolation, thus circumventing the ethical debate commonly associated with the use of human embryonic stem cells. Accumulating evidence now suggests that the amnion, which had been discarded after parturition, is a highly potent transplant material in the field of regenerative medicine. In this report, we review the current progress on the characterization of MSCs derived from the amnion as a remarkable transplantable cell population with therapeutic potential for multiple CNS disorders, especially stroke.https://doi.org/10.3727/096368909788341243 |
| spellingShingle | Seong Jin Yu Maddalena Soncini Yuji Kaneko David C. Hess Ornella Parolini Cesar V. Borlongan Ph.D. Amnion: A Potent Graft Source for Cell Therapy in Stroke Cell Transplantation |
| title | Amnion: A Potent Graft Source for Cell Therapy in Stroke |
| title_full | Amnion: A Potent Graft Source for Cell Therapy in Stroke |
| title_fullStr | Amnion: A Potent Graft Source for Cell Therapy in Stroke |
| title_full_unstemmed | Amnion: A Potent Graft Source for Cell Therapy in Stroke |
| title_short | Amnion: A Potent Graft Source for Cell Therapy in Stroke |
| title_sort | amnion a potent graft source for cell therapy in stroke |
| url | https://doi.org/10.3727/096368909788341243 |
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