Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

Efficient clearance of Aβ protofibrils in AβPP-transgenic mice treated with a brain-penetrating bifunctional antibody

Abstract Background Amyloid-β (Aβ) immunotherapy is one of the most promising disease-modifying strategies for Alzheimer’s disease (AD). Despite recent progress targeting aggregated forms of Aβ, low antibody brain penetrance remains a challenge. In the present study, we used transferrin receptor (Tf...

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Bibliographic Details
Main Authors: Stina Syvänen, Greta Hultqvist, Tobias Gustavsson, Astrid Gumucio, Hanna Laudon, Linda Söderberg, Martin Ingelsson, Lars Lannfelt, Dag Sehlin
Format: Article
Language:English
Published: BMC 2018-05-01
Series:Alzheimer’s Research & Therapy
Subjects:
Alzheimer’s disease (AD)
Immunotherapy
Amyloid-β (Aβ)
Oligomers
Protofibrils
Monoclonal antibody
Online Access:http://link.springer.com/article/10.1186/s13195-018-0377-8

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