A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9

A new compact adenine base editor generated through deletion of HNH and REC2 domain of SpCas9

Abstract Background Adenine base editors (ABEs) are promising therapeutic gene editing tools that can efficiently convert targeted A•T to G•C base pairs in the genome. However, the large size of commonly used ABEs based on SpCas9 hinders its delivery in vivo using certain vectors such as adeno-assoc...

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Bibliographic Details
Main Authors: Yuqiang Qian, Di Wang, Wenchao Niu, Ding Zhao, Jinze Li, Zhiquan Liu, Xun Gao, Yang Han, Liangxue Lai, Zhanjun Li
Format: Article
Language:English
Published: BMC 2023-07-01
Series:BMC Biology
Subjects:
CRISPR/Cas9
Base editor
ABE8e
Reduce size
AAV
Online Access:https://doi.org/10.1186/s12915-023-01644-9

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