Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
Objective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and poi...
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Mashhad University of Medical Sciences
2016-01-01
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Series: | Asia Oceania Journal of Nuclear Medicine and Biology |
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Online Access: | http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.html |
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author | Yasuharu Wakabayashi Kenichi Kashikura Yasuyuki Takahashi Hitoshi Yabe Akihiro Ichikawa Souichi Yamamoto Ayumi Ishii Kunio Doi |
author_facet | Yasuharu Wakabayashi Kenichi Kashikura Yasuyuki Takahashi Hitoshi Yabe Akihiro Ichikawa Souichi Yamamoto Ayumi Ishii Kunio Doi |
author_sort | Yasuharu Wakabayashi |
collection | DOAJ |
description | Objective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). Methods: A cylinder phantom with the sphere (30mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose (18F-FDG) concentrations of 5.3 kBq/ml and 21.2 kBq/ml were used for the background in the cylinder phantom and the central sphere respectively. By the use of TOF and PSF, SUVmax and SUVmean were determined while moving the phantom in a horizontal direction (X direction) from the center of field of view (FOV: 0 mm) at 50, 100, 150 and 200 mm positions, respectively. Furthermore, we examined 41 patients (23 male, 18 female, mean age: 68±11.2 years) with lymph node tumors , who had undergone 18F-FDG PET examinations. The distance of each lymph node from FOV center was measured, based on the clinical images. Results: As the distance of a lesion from the FOV center exceeded 100 mm, the value of SUVmax, which was obtained with the cylinder phantom, was overestimated, while SUVmean by TOF and/or PSF was underestimated. Based on the clinical examinations, the average volume of interest was 8.5 cm3. Concomitant use of PSF increased SUVmax and SUVmean by 27.9% and 2.8%, respectively. However, size of VOI and distance from the FOV center did not affect SUVmax or SUVmean in clinical examinations. Conclusion: The reliability of SUV quantification by TOF and/or PSF decreased, when the tumor was located at a 100 mm distance (or farther) from the center of FOV. In clinical examinations, if the lymph node was located within 100 mm distance from the center of FOV, SUV remained stable within a constantly increasing range by use of both TOF and PSF. We conclude that, use of both TOF and PSF may be helpful. |
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language | English |
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spelling | doaj.art-f12ccca586cb40eab9f1b2dc72b5f0852022-12-21T23:42:04ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262016-01-0141455010.7508/aojnmb.2016.04.0076167Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread FunctionYasuharu Wakabayashi0Kenichi Kashikura1Yasuyuki Takahashi2Hitoshi Yabe3Akihiro Ichikawa4Souichi Yamamoto5Ayumi Ishii6Kunio Doi7Division of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanGraduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, JapanGraduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, JapanDivision of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDivision of Molecular Imaging, Saitama Prefectural Cancer Center, Saitama, JapanDivision of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanDivision of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanDepartment of Radiology, University of Chicago, Chicago, Illinois, USAObjective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). Methods: A cylinder phantom with the sphere (30mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose (18F-FDG) concentrations of 5.3 kBq/ml and 21.2 kBq/ml were used for the background in the cylinder phantom and the central sphere respectively. By the use of TOF and PSF, SUVmax and SUVmean were determined while moving the phantom in a horizontal direction (X direction) from the center of field of view (FOV: 0 mm) at 50, 100, 150 and 200 mm positions, respectively. Furthermore, we examined 41 patients (23 male, 18 female, mean age: 68±11.2 years) with lymph node tumors , who had undergone 18F-FDG PET examinations. The distance of each lymph node from FOV center was measured, based on the clinical images. Results: As the distance of a lesion from the FOV center exceeded 100 mm, the value of SUVmax, which was obtained with the cylinder phantom, was overestimated, while SUVmean by TOF and/or PSF was underestimated. Based on the clinical examinations, the average volume of interest was 8.5 cm3. Concomitant use of PSF increased SUVmax and SUVmean by 27.9% and 2.8%, respectively. However, size of VOI and distance from the FOV center did not affect SUVmax or SUVmean in clinical examinations. Conclusion: The reliability of SUV quantification by TOF and/or PSF decreased, when the tumor was located at a 100 mm distance (or farther) from the center of FOV. In clinical examinations, if the lymph node was located within 100 mm distance from the center of FOV, SUV remained stable within a constantly increasing range by use of both TOF and PSF. We conclude that, use of both TOF and PSF may be helpful.http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.htmlstandardized uptake valuetime-of-flightpoint-spread-function18F-FDG tumor size |
spellingShingle | Yasuharu Wakabayashi Kenichi Kashikura Yasuyuki Takahashi Hitoshi Yabe Akihiro Ichikawa Souichi Yamamoto Ayumi Ishii Kunio Doi Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function Asia Oceania Journal of Nuclear Medicine and Biology standardized uptake value time-of-flight point-spread-function 18F-FDG tumor size |
title | Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function |
title_full | Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function |
title_fullStr | Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function |
title_full_unstemmed | Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function |
title_short | Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function |
title_sort | evaluation of the effect of tumor position on standardized uptake value using time of flight reconstruction and point spread function |
topic | standardized uptake value time-of-flight point-spread-function 18F-FDG tumor size |
url | http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.html |
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