Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function

Objective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and poi...

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Main Authors: Yasuharu Wakabayashi, Kenichi Kashikura, Yasuyuki Takahashi, Hitoshi Yabe, Akihiro Ichikawa, Souichi Yamamoto, Ayumi Ishii, Kunio Doi
Format: Article
Language:English
Published: Mashhad University of Medical Sciences 2016-01-01
Series:Asia Oceania Journal of Nuclear Medicine and Biology
Subjects:
Online Access:http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.html
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author Yasuharu Wakabayashi
Kenichi Kashikura
Yasuyuki Takahashi
Hitoshi Yabe
Akihiro Ichikawa
Souichi Yamamoto
Ayumi Ishii
Kunio Doi
author_facet Yasuharu Wakabayashi
Kenichi Kashikura
Yasuyuki Takahashi
Hitoshi Yabe
Akihiro Ichikawa
Souichi Yamamoto
Ayumi Ishii
Kunio Doi
author_sort Yasuharu Wakabayashi
collection DOAJ
description Objective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). Methods: A cylinder phantom with the sphere (30mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose (18F-FDG) concentrations of 5.3 kBq/ml and 21.2 kBq/ml were used for the background in the cylinder phantom and the central sphere respectively. By the use of TOF and PSF, SUVmax and SUVmean were determined while moving the phantom in a horizontal direction (X direction) from the center of field of view (FOV: 0 mm) at 50, 100, 150 and 200 mm positions, respectively. Furthermore, we examined 41 patients (23 male, 18 female, mean age: 68±11.2 years) with lymph node tumors , who had undergone 18F-FDG PET examinations. The distance of each lymph node from FOV center was measured, based on the clinical images. Results: As the distance of a lesion from the FOV center exceeded 100 mm, the value of SUVmax, which was obtained with the cylinder phantom, was overestimated, while SUVmean by TOF and/or PSF was underestimated. Based on the clinical examinations, the average volume of interest was 8.5 cm3. Concomitant use of PSF increased SUVmax and SUVmean by 27.9% and 2.8%, respectively. However, size of VOI and distance from the FOV center did not affect SUVmax or SUVmean in clinical examinations. Conclusion: The reliability of SUV quantification by TOF and/or PSF decreased, when the tumor was located at a 100 mm distance (or farther) from the center of FOV. In clinical examinations, if the lymph node was located within 100 mm distance from the center of FOV, SUV remained stable within a constantly increasing range by use of both TOF and PSF. We conclude that, use of both TOF and PSF may be helpful.
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spelling doaj.art-f12ccca586cb40eab9f1b2dc72b5f0852022-12-21T23:42:04ZengMashhad University of Medical SciencesAsia Oceania Journal of Nuclear Medicine and Biology2322-57182322-57262016-01-0141455010.7508/aojnmb.2016.04.0076167Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread FunctionYasuharu Wakabayashi0Kenichi Kashikura1Yasuyuki Takahashi2Hitoshi Yabe3Akihiro Ichikawa4Souichi Yamamoto5Ayumi Ishii6Kunio Doi7Division of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanGraduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, JapanGraduate School of Radiological Technology, Gunma Prefectural College of Health Sciences, Gunma, JapanDivision of Health Sciences, Graduate School of Medical Sciences, Kanazawa University, Kanazawa, JapanDivision of Molecular Imaging, Saitama Prefectural Cancer Center, Saitama, JapanDivision of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanDivision of Radiological Technology, Saitama Prefectural Cancer Center, Saitama, JapanDepartment of Radiology, University of Chicago, Chicago, Illinois, USAObjective(s): The present study was conducted to examine whether the standardized uptake value (SUV) may be affected by the spatial position of a lesion in the radial direction on positron emission tomography (PET) images, obtained via two methods based on time-of-flight (TOF) reconstruction and point spread function (PSF). Methods: A cylinder phantom with the sphere (30mm diameter), located in the center was used in this study. Fluorine-18 fluorodeoxyglucose (18F-FDG) concentrations of 5.3 kBq/ml and 21.2 kBq/ml were used for the background in the cylinder phantom and the central sphere respectively. By the use of TOF and PSF, SUVmax and SUVmean were determined while moving the phantom in a horizontal direction (X direction) from the center of field of view (FOV: 0 mm) at 50, 100, 150 and 200 mm positions, respectively. Furthermore, we examined 41 patients (23 male, 18 female, mean age: 68±11.2 years) with lymph node tumors , who had undergone 18F-FDG PET examinations. The distance of each lymph node from FOV center was measured, based on the clinical images. Results: As the distance of a lesion from the FOV center exceeded 100 mm, the value of SUVmax, which was obtained with the cylinder phantom, was overestimated, while SUVmean by TOF and/or PSF was underestimated. Based on the clinical examinations, the average volume of interest was 8.5 cm3. Concomitant use of PSF increased SUVmax and SUVmean by 27.9% and 2.8%, respectively. However, size of VOI and distance from the FOV center did not affect SUVmax or SUVmean in clinical examinations. Conclusion: The reliability of SUV quantification by TOF and/or PSF decreased, when the tumor was located at a 100 mm distance (or farther) from the center of FOV. In clinical examinations, if the lymph node was located within 100 mm distance from the center of FOV, SUV remained stable within a constantly increasing range by use of both TOF and PSF. We conclude that, use of both TOF and PSF may be helpful.http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.htmlstandardized uptake valuetime-of-flightpoint-spread-function18F-FDG  tumor size
spellingShingle Yasuharu Wakabayashi
Kenichi Kashikura
Yasuyuki Takahashi
Hitoshi Yabe
Akihiro Ichikawa
Souichi Yamamoto
Ayumi Ishii
Kunio Doi
Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
Asia Oceania Journal of Nuclear Medicine and Biology
standardized uptake value
time-of-flight
point-spread-function
18F-FDG 
 tumor size
title Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
title_full Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
title_fullStr Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
title_full_unstemmed Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
title_short Evaluation of the Effect of Tumor Position on Standardized Uptake Value Using Time-of-Flight Reconstruction and Point Spread Function
title_sort evaluation of the effect of tumor position on standardized uptake value using time of flight reconstruction and point spread function
topic standardized uptake value
time-of-flight
point-spread-function
18F-FDG 
 tumor size
url http://aojnmb.mums.ac.ir/pdf_6167_40ffe4e67dd66c4617a121f3f384d5d4.html
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