Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals.
We performed a cross-sectional study including 533 individuals (median age 61) from the highly TBE endemic Åland Islands in the archipelago between Sweden and Finland. Blood samples, questionnaires and vaccination records were obtained from all study participants. The aim was to investigate if there...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Public Library of Science (PLoS)
2014-01-01
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| Series: | PLoS ONE |
| Online Access: | http://europepmc.org/articles/PMC4072701?pdf=render |
| _version_ | 1811205445233147904 |
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| author | Pontus Lindblom Peter Wilhelmsson Linda Fryland Andreas Matussek Mats Haglund Johanna Sjöwall Sirkka Vene Dag Nyman Pia Forsberg Per-Eric Lindgren |
| author_facet | Pontus Lindblom Peter Wilhelmsson Linda Fryland Andreas Matussek Mats Haglund Johanna Sjöwall Sirkka Vene Dag Nyman Pia Forsberg Per-Eric Lindgren |
| author_sort | Pontus Lindblom |
| collection | DOAJ |
| description | We performed a cross-sectional study including 533 individuals (median age 61) from the highly TBE endemic Åland Islands in the archipelago between Sweden and Finland. Blood samples, questionnaires and vaccination records were obtained from all study participants. The aim was to investigate if there was any association between TBEV antibody titer and 12 health-related factors. Measurement of TBEV IgG antibodies was performed using two commercial ELISA assays (Enzygnost and Immunozym), and a third in-house rapid fluorescent focus inhibition test was used to measure TBEV neutralizing antibodies. The age of the individual and the number of vaccine doses were the two most important factors determining the immunological response to vaccination. The response to each vaccine dose declined linearly with increased age. A 35 year age difference corresponds to a vaccine dose increment from 3 to 4 to achieve the same immunological response. Participants previously vaccinated against other flaviviruses had lower odds of being seropositive for neutralizing TBEV antibodies on average, while participants with self-reported asthma had higher odds of being seropositive. By comparing the 3 serological assays we show that the Enzygnost and Immunozym assay differ due to choice of cutoffs, but not in overall accuracy. |
| first_indexed | 2024-04-12T03:31:43Z |
| format | Article |
| id | doaj.art-f12ce753ea2d490dabecc5ebf6c182e7 |
| institution | Directory Open Access Journal |
| issn | 1932-6203 |
| language | English |
| last_indexed | 2024-04-12T03:31:43Z |
| publishDate | 2014-01-01 |
| publisher | Public Library of Science (PLoS) |
| record_format | Article |
| series | PLoS ONE |
| spelling | doaj.art-f12ce753ea2d490dabecc5ebf6c182e72022-12-22T03:49:32ZengPublic Library of Science (PLoS)PLoS ONE1932-62032014-01-0196e10086010.1371/journal.pone.0100860Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals.Pontus LindblomPeter WilhelmssonLinda FrylandAndreas MatussekMats HaglundJohanna SjöwallSirkka VeneDag NymanPia ForsbergPer-Eric LindgrenWe performed a cross-sectional study including 533 individuals (median age 61) from the highly TBE endemic Åland Islands in the archipelago between Sweden and Finland. Blood samples, questionnaires and vaccination records were obtained from all study participants. The aim was to investigate if there was any association between TBEV antibody titer and 12 health-related factors. Measurement of TBEV IgG antibodies was performed using two commercial ELISA assays (Enzygnost and Immunozym), and a third in-house rapid fluorescent focus inhibition test was used to measure TBEV neutralizing antibodies. The age of the individual and the number of vaccine doses were the two most important factors determining the immunological response to vaccination. The response to each vaccine dose declined linearly with increased age. A 35 year age difference corresponds to a vaccine dose increment from 3 to 4 to achieve the same immunological response. Participants previously vaccinated against other flaviviruses had lower odds of being seropositive for neutralizing TBEV antibodies on average, while participants with self-reported asthma had higher odds of being seropositive. By comparing the 3 serological assays we show that the Enzygnost and Immunozym assay differ due to choice of cutoffs, but not in overall accuracy.http://europepmc.org/articles/PMC4072701?pdf=render |
| spellingShingle | Pontus Lindblom Peter Wilhelmsson Linda Fryland Andreas Matussek Mats Haglund Johanna Sjöwall Sirkka Vene Dag Nyman Pia Forsberg Per-Eric Lindgren Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. PLoS ONE |
| title | Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. |
| title_full | Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. |
| title_fullStr | Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. |
| title_full_unstemmed | Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. |
| title_short | Factors determining immunological response to vaccination against tick-borne encephalitis virus in older individuals. |
| title_sort | factors determining immunological response to vaccination against tick borne encephalitis virus in older individuals |
| url | http://europepmc.org/articles/PMC4072701?pdf=render |
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