Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles
Background: The nature acts like a large “bio-laboratory” comprising plants, algae, fungi, yeast, etc., which are composed of biomolecules. These naturally occurring biomolecules have been identified to play an active role in the formation of nanoparticles. Methods: This research work mainly aims to...
Main Authors: | , , , , |
---|---|
Format: | Article |
Language: | English |
Published: |
Wolters Kluwer Medknow Publications
2022-01-01
|
Series: | Biomedical and Biotechnology Research Journal |
Subjects: | |
Online Access: | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=341;epage=348;aulast=Agila |
_version_ | 1811239243839700992 |
---|---|
author | Aranganathan Agila Joseph Devaraj Rosaline Vimala Moses Stella Bharathy Gnanasekar Dayana Jeyaleela Sagaya Adaikalaraj Margrat Sheela |
author_facet | Aranganathan Agila Joseph Devaraj Rosaline Vimala Moses Stella Bharathy Gnanasekar Dayana Jeyaleela Sagaya Adaikalaraj Margrat Sheela |
author_sort | Aranganathan Agila |
collection | DOAJ |
description | Background: The nature acts like a large “bio-laboratory” comprising plants, algae, fungi, yeast, etc., which are composed of biomolecules. These naturally occurring biomolecules have been identified to play an active role in the formation of nanoparticles. Methods: This research work mainly aims to investigate the anti-oxidant (diphenylpicrylhydrazyl assay) and anti-cancer (Michigan cancer foundation-7 cell line) capacities of biologically prepared copper oxide mediated from the hydroalcoholic extract of Justicia glauca by simple precipitation and also to identify the phytochemicals in the extract by qualitatively. Results: On screening test, the extract shows the presence of carbohydrate, phenolics, alkaloids, and terpenoids saponins which are chiefly act as a reducing, stabilizing, and capping agents in nanomaterial preparations. The medicinal plant Justicia glauca extract-mediated copper oxide materials were synthesized by lost cost, simple, effective, and eco-friendly precipitation method. The prepared copper nanomaterials were characterized by ultraviolet–visible, Fourier-transform infrared spectroscopy, energy dispersive X-ray analysis, X-ray diffraction, and scanning electron microscope. The obtained spectral results reveal that the prepared particles were found to be elliptical flat shapes of copper oxide with the average size of 19.72 nm with 51.11% of copper and 48.89% of oxygen elements. Especially, on anti-oxidant and anti-cancer activities the prepared Justicia glauca extract-mediated copper oxide revealed excellent potent while comparing the other green synthesized copper oxide particles. Conclusion: Overall results evidenced that the aqueous extract of Justicia glauca is a very good bioreductant for the synthesis of copper oxide nanoparticles. |
first_indexed | 2024-04-12T12:57:27Z |
format | Article |
id | doaj.art-f1304f2aab884c18b27713709c6f4502 |
institution | Directory Open Access Journal |
issn | 2588-9834 2588-9842 |
language | English |
last_indexed | 2024-04-12T12:57:27Z |
publishDate | 2022-01-01 |
publisher | Wolters Kluwer Medknow Publications |
record_format | Article |
series | Biomedical and Biotechnology Research Journal |
spelling | doaj.art-f1304f2aab884c18b27713709c6f45022022-12-22T03:32:18ZengWolters Kluwer Medknow PublicationsBiomedical and Biotechnology Research Journal2588-98342588-98422022-01-016334134810.4103/bbrj.bbrj_136_22Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticlesAranganathan AgilaJoseph Devaraj Rosaline VimalaMoses Stella BharathyGnanasekar Dayana JeyaleelaSagaya Adaikalaraj Margrat SheelaBackground: The nature acts like a large “bio-laboratory” comprising plants, algae, fungi, yeast, etc., which are composed of biomolecules. These naturally occurring biomolecules have been identified to play an active role in the formation of nanoparticles. Methods: This research work mainly aims to investigate the anti-oxidant (diphenylpicrylhydrazyl assay) and anti-cancer (Michigan cancer foundation-7 cell line) capacities of biologically prepared copper oxide mediated from the hydroalcoholic extract of Justicia glauca by simple precipitation and also to identify the phytochemicals in the extract by qualitatively. Results: On screening test, the extract shows the presence of carbohydrate, phenolics, alkaloids, and terpenoids saponins which are chiefly act as a reducing, stabilizing, and capping agents in nanomaterial preparations. The medicinal plant Justicia glauca extract-mediated copper oxide materials were synthesized by lost cost, simple, effective, and eco-friendly precipitation method. The prepared copper nanomaterials were characterized by ultraviolet–visible, Fourier-transform infrared spectroscopy, energy dispersive X-ray analysis, X-ray diffraction, and scanning electron microscope. The obtained spectral results reveal that the prepared particles were found to be elliptical flat shapes of copper oxide with the average size of 19.72 nm with 51.11% of copper and 48.89% of oxygen elements. Especially, on anti-oxidant and anti-cancer activities the prepared Justicia glauca extract-mediated copper oxide revealed excellent potent while comparing the other green synthesized copper oxide particles. Conclusion: Overall results evidenced that the aqueous extract of Justicia glauca is a very good bioreductant for the synthesis of copper oxide nanoparticles.http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=341;epage=348;aulast=Agilaanti-cancer activityanti-oxidant activitycopper (ii) sulfate pentahydratecopper oxide nanoparticlesjusticia glauca extract |
spellingShingle | Aranganathan Agila Joseph Devaraj Rosaline Vimala Moses Stella Bharathy Gnanasekar Dayana Jeyaleela Sagaya Adaikalaraj Margrat Sheela Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles Biomedical and Biotechnology Research Journal anti-cancer activity anti-oxidant activity copper (ii) sulfate pentahydrate copper oxide nanoparticles justicia glauca extract |
title | Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles |
title_full | Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles |
title_fullStr | Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles |
title_full_unstemmed | Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles |
title_short | Anti-Oxidant and anti-cancer activities of biogenic synthesized copper oxide nanoparticles |
title_sort | anti oxidant and anti cancer activities of biogenic synthesized copper oxide nanoparticles |
topic | anti-cancer activity anti-oxidant activity copper (ii) sulfate pentahydrate copper oxide nanoparticles justicia glauca extract |
url | http://www.bmbtrj.org/article.asp?issn=2588-9834;year=2022;volume=6;issue=3;spage=341;epage=348;aulast=Agila |
work_keys_str_mv | AT aranganathanagila antioxidantandanticanceractivitiesofbiogenicsynthesizedcopperoxidenanoparticles AT josephdevarajrosalinevimala antioxidantandanticanceractivitiesofbiogenicsynthesizedcopperoxidenanoparticles AT mosesstellabharathy antioxidantandanticanceractivitiesofbiogenicsynthesizedcopperoxidenanoparticles AT gnanasekardayanajeyaleela antioxidantandanticanceractivitiesofbiogenicsynthesizedcopperoxidenanoparticles AT sagayaadaikalarajmargratsheela antioxidantandanticanceractivitiesofbiogenicsynthesizedcopperoxidenanoparticles |