Remote Ischemic Preconditioning and Diabetic Macular Edema
Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influe...
| Main Authors: | , , , , , , |
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| Format: | Article |
| Language: | English |
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Shahid Sadoughi University of Medical Sciences
2018-10-01
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| Series: | Iranian Journal of Diabetes and Obesity |
| Subjects: | |
| Online Access: | http://ijdo.ssu.ac.ir/article-1-446-en.html |
| _version_ | 1817990648689590272 |
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| author | Masoud Reza Manaviat Mansour Rafiee Fariba Sepehri Narjes Hazar Ahmad Shojaaldini Saeedeh Jam Ashkezari Masoud Rahmanian |
| author_facet | Masoud Reza Manaviat Mansour Rafiee Fariba Sepehri Narjes Hazar Ahmad Shojaaldini Saeedeh Jam Ashkezari Masoud Rahmanian |
| author_sort | Masoud Reza Manaviat |
| collection | DOAJ |
| description | Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were candidate to receive anti-VEGF therapy.
Materials and Methods: In this Single blinded, randomized controlled trial, 40 eligible type 2 diabetes mellitus (T2DM) patients with macular edema who were candidate to receive anti-VEGF therapy randomized into intervention (CP) and sham controlling (SP). The CP received RIPC in three consecutive days before anti-VEGF injection. Data of optical cochrane tomography (OPC) before and 10 days after procedure were compared as outcomes.
Results: Central foveal volume and visual acuity mean difference before and after intra-vitral anti-VEGF injection in both groups was significant. There were no significant mean differences in central macular thickness in case groups. Comparing the mean between two groups did not show a significant difference in visual acuity, central foveal volume (P-value: 0.69) and central macular thickness (P-value: 0.62). There were no significant differences in the desired changes pattern of DME between two groups (P-value: 1.00).
Conclusion: This pilot study did not show any additive positive effect of RIPC on retinal outcomes especially visual acuity in T2DM patients with DME who were received anti-VEGF treatment. |
| first_indexed | 2024-04-14T01:01:57Z |
| format | Article |
| id | doaj.art-f131b899169249558cc1065d8cdd11a4 |
| institution | Directory Open Access Journal |
| issn | 2008-6792 2345-2250 |
| language | English |
| last_indexed | 2024-04-14T01:01:57Z |
| publishDate | 2018-10-01 |
| publisher | Shahid Sadoughi University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Diabetes and Obesity |
| spelling | doaj.art-f131b899169249558cc1065d8cdd11a42022-12-22T02:21:23ZengShahid Sadoughi University of Medical SciencesIranian Journal of Diabetes and Obesity2008-67922345-22502018-10-01104172177Remote Ischemic Preconditioning and Diabetic Macular EdemaMasoud Reza Manaviat0Mansour Rafiee1Fariba Sepehri2Narjes Hazar3Ahmad Shojaaldini4Saeedeh Jam Ashkezari5Masoud Rahmanian6 Professor of Ophthalmology, Department of Ophthalmology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Associate Professor, Department of Internal Medicine, Cardiovascular division, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. MA. Clinical Psychology, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. MD. Community Medicine Specialist. Department of Community Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. MD. Department of Occupational Medicine, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. MA. Researcher, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Assistant Professor, Diabetes Research Center, Shahid Sadoughi University of Medical Sciences, Yazd, Iran. Objective: Remote Ischemic Preconditioning (RIPC) as the transient ischemia and reperfusion of the arm is a promising method for protecting different tissue from future ischemia. These effects might be mediated through vascular and endothelial growth factor (VEGF) pathway. We investigated the influence of RIPC on diabetic macular edema (DME) as a chronic ischemic condition in patients who were candidate to receive anti-VEGF therapy. Materials and Methods: In this Single blinded, randomized controlled trial, 40 eligible type 2 diabetes mellitus (T2DM) patients with macular edema who were candidate to receive anti-VEGF therapy randomized into intervention (CP) and sham controlling (SP). The CP received RIPC in three consecutive days before anti-VEGF injection. Data of optical cochrane tomography (OPC) before and 10 days after procedure were compared as outcomes. Results: Central foveal volume and visual acuity mean difference before and after intra-vitral anti-VEGF injection in both groups was significant. There were no significant mean differences in central macular thickness in case groups. Comparing the mean between two groups did not show a significant difference in visual acuity, central foveal volume (P-value: 0.69) and central macular thickness (P-value: 0.62). There were no significant differences in the desired changes pattern of DME between two groups (P-value: 1.00). Conclusion: This pilot study did not show any additive positive effect of RIPC on retinal outcomes especially visual acuity in T2DM patients with DME who were received anti-VEGF treatment.http://ijdo.ssu.ac.ir/article-1-446-en.htmlIschemic preconditioningType 2 diabetes mellitusMacular edemaanti-VEGF |
| spellingShingle | Masoud Reza Manaviat Mansour Rafiee Fariba Sepehri Narjes Hazar Ahmad Shojaaldini Saeedeh Jam Ashkezari Masoud Rahmanian Remote Ischemic Preconditioning and Diabetic Macular Edema Iranian Journal of Diabetes and Obesity Ischemic preconditioning Type 2 diabetes mellitus Macular edema anti-VEGF |
| title | Remote Ischemic Preconditioning and Diabetic Macular Edema |
| title_full | Remote Ischemic Preconditioning and Diabetic Macular Edema |
| title_fullStr | Remote Ischemic Preconditioning and Diabetic Macular Edema |
| title_full_unstemmed | Remote Ischemic Preconditioning and Diabetic Macular Edema |
| title_short | Remote Ischemic Preconditioning and Diabetic Macular Edema |
| title_sort | remote ischemic preconditioning and diabetic macular edema |
| topic | Ischemic preconditioning Type 2 diabetes mellitus Macular edema anti-VEGF |
| url | http://ijdo.ssu.ac.ir/article-1-446-en.html |
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