Immune Targeted Therapies for COVID-19 Infection: A Narrative Review
In December 2019, the coronavirus disease-2019 (COVID-19) outbreak emerged in Wuhan, China. The World Health Organization officially declared it a pandemic on March 11, 2020. Reports indicated that the associated mortality of the infection is quite higher in the elderly, individuals with specific co...
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| Format: | Article |
| Language: | English |
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Shiraz University of Medical Sciences
2022-07-01
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| Series: | Iranian Journal of Medical Sciences |
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| Online Access: | https://ijms.sums.ac.ir/article_48248_bd968046634f2d4d07d48863c224e1b3.pdf |
| _version_ | 1811219030427566080 |
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| author | Bahareh Forouzani-Haghighi Alireza Rezvani Afsaneh Vazin |
| author_facet | Bahareh Forouzani-Haghighi Alireza Rezvani Afsaneh Vazin |
| author_sort | Bahareh Forouzani-Haghighi |
| collection | DOAJ |
| description | In December 2019, the coronavirus disease-2019 (COVID-19) outbreak emerged in Wuhan, China. The World Health Organization officially declared it a pandemic on March 11, 2020. Reports indicated that the associated mortality of the infection is quite higher in the elderly, individuals with specific comorbidities (such as diabetes mellitus), and generally the ones with a compromised immune system. A cohort study in Wuhan, China, reported a dysregulated immune response in 452 patients with laboratory-confirmed COVID-19. As a result of this suppressed immune response, an increase in neutrophil to lymphocyte ratio, T lymphopenia, and a decrease in CD4+ T cells were all common laboratory findings, especially in severe cases.On the other hand, there is substantial evidence of T cell exhaustion in critically ill patients. Accordingly, the immune system seems to play an important role in the prognosis and pathogenesis of the disease. Therefore, this study aims to review the evidence on the immune response dysregulation in COVID-19 infection and the potential role of immunoregulatory treatments such as immune checkpoint inhibitors, interferons, and CD200 inhibitors in altering disease prognosis, especially in critically ill patients. |
| first_indexed | 2024-04-12T07:18:52Z |
| format | Article |
| id | doaj.art-f13642fd5d9a4ef997234b04b18a2f10 |
| institution | Directory Open Access Journal |
| issn | 0253-0716 1735-3688 |
| language | English |
| last_indexed | 2024-04-12T07:18:52Z |
| publishDate | 2022-07-01 |
| publisher | Shiraz University of Medical Sciences |
| record_format | Article |
| series | Iranian Journal of Medical Sciences |
| spelling | doaj.art-f13642fd5d9a4ef997234b04b18a2f102022-12-22T03:42:23ZengShiraz University of Medical SciencesIranian Journal of Medical Sciences0253-07161735-36882022-07-0147429129910.30476/ijms.2021.91614.227748248Immune Targeted Therapies for COVID-19 Infection: A Narrative ReviewBahareh Forouzani-Haghighi0Alireza Rezvani1Afsaneh Vazin2Department of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Hematology and Medical Oncology, School of Medicine, Shiraz University of Medical Sciences, Shiraz, IranDepartment of Clinical Pharmacy, School of Pharmacy, Shiraz University of Medical Sciences, Shiraz, IranIn December 2019, the coronavirus disease-2019 (COVID-19) outbreak emerged in Wuhan, China. The World Health Organization officially declared it a pandemic on March 11, 2020. Reports indicated that the associated mortality of the infection is quite higher in the elderly, individuals with specific comorbidities (such as diabetes mellitus), and generally the ones with a compromised immune system. A cohort study in Wuhan, China, reported a dysregulated immune response in 452 patients with laboratory-confirmed COVID-19. As a result of this suppressed immune response, an increase in neutrophil to lymphocyte ratio, T lymphopenia, and a decrease in CD4+ T cells were all common laboratory findings, especially in severe cases.On the other hand, there is substantial evidence of T cell exhaustion in critically ill patients. Accordingly, the immune system seems to play an important role in the prognosis and pathogenesis of the disease. Therefore, this study aims to review the evidence on the immune response dysregulation in COVID-19 infection and the potential role of immunoregulatory treatments such as immune checkpoint inhibitors, interferons, and CD200 inhibitors in altering disease prognosis, especially in critically ill patients.https://ijms.sums.ac.ir/article_48248_bd968046634f2d4d07d48863c224e1b3.pdfimmunotherapycovid-19immune checkpoint inhibitorst-lymphocytes |
| spellingShingle | Bahareh Forouzani-Haghighi Alireza Rezvani Afsaneh Vazin Immune Targeted Therapies for COVID-19 Infection: A Narrative Review Iranian Journal of Medical Sciences immunotherapy covid-19 immune checkpoint inhibitors t-lymphocytes |
| title | Immune Targeted Therapies for COVID-19 Infection: A Narrative Review |
| title_full | Immune Targeted Therapies for COVID-19 Infection: A Narrative Review |
| title_fullStr | Immune Targeted Therapies for COVID-19 Infection: A Narrative Review |
| title_full_unstemmed | Immune Targeted Therapies for COVID-19 Infection: A Narrative Review |
| title_short | Immune Targeted Therapies for COVID-19 Infection: A Narrative Review |
| title_sort | immune targeted therapies for covid 19 infection a narrative review |
| topic | immunotherapy covid-19 immune checkpoint inhibitors t-lymphocytes |
| url | https://ijms.sums.ac.ir/article_48248_bd968046634f2d4d07d48863c224e1b3.pdf |
| work_keys_str_mv | AT baharehforouzanihaghighi immunetargetedtherapiesforcovid19infectionanarrativereview AT alirezarezvani immunetargetedtherapiesforcovid19infectionanarrativereview AT afsanehvazin immunetargetedtherapiesforcovid19infectionanarrativereview |