Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer
Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining...
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| Format: | Article |
| Language: | English |
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MDPI AG
2021-03-01
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| Series: | Nutrients |
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| Online Access: | https://www.mdpi.com/2072-6643/13/3/1029 |
| _version_ | 1797540395078385664 |
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| author | Ulrike Kämmerer Rainer J. Klement Fabian T. Joos Marc Sütterlin Monika Reuss-Borst |
| author_facet | Ulrike Kämmerer Rainer J. Klement Fabian T. Joos Marc Sütterlin Monika Reuss-Borst |
| author_sort | Ulrike Kämmerer |
| collection | DOAJ |
| description | Breast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient and outpatient phases for 20 weeks. Female BC patients (<i>n</i> = 152; mean age 51.7 years) could select their diet. Data collected were: Quality of life (QoL), spiroergometry, body composition, and blood parameters. In total 30, 92, and 30 patients started the KD, LCD, and SD, respectively. Of those, 20, 76, and 25 completed the final examination. Patients rated all diets as feasible in daily life. All groups enhanced QoL, body composition, and physical performance. LCD participants showed the most impressive improvement in QoL aspects. KD participants finished with a very good physical performance and muscle/fat ratio. Despite increased cholesterol levels, KD patients had the best triglyceride/high-density lipoprotein (HDL) ratio and homeostatic model assessment of insulin resistance index (HOMA-IR). Most metabolic parameters significantly improved in the LCD group. SD participants ended with remarkably low cholesterol levels but did not improve triglyceride/HDL or HOMA-IR. In conclusion, both well-defined KDs and LCDs are safe and beneficial for BC patients and can be recommended during the rehabilitation phase. |
| first_indexed | 2024-03-10T13:00:30Z |
| format | Article |
| id | doaj.art-f136bbad22614c84a95014d2c1d3181b |
| institution | Directory Open Access Journal |
| issn | 2072-6643 |
| language | English |
| last_indexed | 2024-03-10T13:00:30Z |
| publishDate | 2021-03-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Nutrients |
| spelling | doaj.art-f136bbad22614c84a95014d2c1d3181b2023-11-21T11:36:56ZengMDPI AGNutrients2072-66432021-03-01133102910.3390/nu13031029Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast CancerUlrike Kämmerer0Rainer J. Klement1Fabian T. Joos2Marc Sütterlin3Monika Reuss-Borst4Department of Obstetrics and Gynaecology, University Hospital of Würzburg, D-97080 Würzburg, GermanyDepartment of Radiation Oncology, Leopoldina Hospital Schweinfurt, D-97422 Schweinfurt, GermanyDepartement of Anaesthesiology, Regional Clinic Holding RKH GmbH, D-71640 Ludwigsburg, GermanyUniversity Medical Center Mannheim, Heidelberg University, D-68159 Mannheim, GermanyCenter for Rehabilitation and Prevention Bad Bocklet, D-97708 Bad Bocklet, GermanyBreast cancer (BC) patients often ask for a healthy diet. Here, we investigated a healthy standard diet (SD), a low carb diet (LCD), and a ketogenic diet (KD) for BC patients during the rehabilitation phase. KOLIBRI was an open-label non-randomized one-site nutritional intervention trial, combining inpatient and outpatient phases for 20 weeks. Female BC patients (<i>n</i> = 152; mean age 51.7 years) could select their diet. Data collected were: Quality of life (QoL), spiroergometry, body composition, and blood parameters. In total 30, 92, and 30 patients started the KD, LCD, and SD, respectively. Of those, 20, 76, and 25 completed the final examination. Patients rated all diets as feasible in daily life. All groups enhanced QoL, body composition, and physical performance. LCD participants showed the most impressive improvement in QoL aspects. KD participants finished with a very good physical performance and muscle/fat ratio. Despite increased cholesterol levels, KD patients had the best triglyceride/high-density lipoprotein (HDL) ratio and homeostatic model assessment of insulin resistance index (HOMA-IR). Most metabolic parameters significantly improved in the LCD group. SD participants ended with remarkably low cholesterol levels but did not improve triglyceride/HDL or HOMA-IR. In conclusion, both well-defined KDs and LCDs are safe and beneficial for BC patients and can be recommended during the rehabilitation phase.https://www.mdpi.com/2072-6643/13/3/1029breast cancerrehabilitationketogenic dietlow carb dietsupportive care |
| spellingShingle | Ulrike Kämmerer Rainer J. Klement Fabian T. Joos Marc Sütterlin Monika Reuss-Borst Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer Nutrients breast cancer rehabilitation ketogenic diet low carb diet supportive care |
| title | Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer |
| title_full | Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer |
| title_fullStr | Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer |
| title_full_unstemmed | Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer |
| title_short | Low Carb and Ketogenic Diets Increase Quality of Life, Physical Performance, Body Composition, and Metabolic Health of Women with Breast Cancer |
| title_sort | low carb and ketogenic diets increase quality of life physical performance body composition and metabolic health of women with breast cancer |
| topic | breast cancer rehabilitation ketogenic diet low carb diet supportive care |
| url | https://www.mdpi.com/2072-6643/13/3/1029 |
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