Breathing adapted radiotherapy: a 4D gating software for lung cancer
<p>Abstract</p> <p>Purpose</p> <p>Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy (RT). The optimal respiratory phase for beam-on may be assessed with a respiratory phase optimizer (R...
| Main Authors: | , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
BMC
2011-06-01
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| Series: | Radiation Oncology |
| Subjects: | |
| Online Access: | http://www.ro-journal.com/content/6/1/78 |
| _version_ | 1828288315838693376 |
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| author | Zaidi Habib Azria David Fenoglietto Pascal Vinh-Hung Vincent Vock Jacqueline Peguret Nicolas Wissmeyer Michael Ratib Osman Miralbell Raymond |
| author_facet | Zaidi Habib Azria David Fenoglietto Pascal Vinh-Hung Vincent Vock Jacqueline Peguret Nicolas Wissmeyer Michael Ratib Osman Miralbell Raymond |
| author_sort | Zaidi Habib |
| collection | DOAJ |
| description | <p>Abstract</p> <p>Purpose</p> <p>Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy (RT). The optimal respiratory phase for beam-on may be assessed with a respiratory phase optimizer (RPO), a 4D image processing software developed with this purpose.</p> <p>Methods and Materials</p> <p>Fourteen patients with lung cancer were included in the study. Every patient underwent a 4D-CT providing ten datasets of ten phases of the respiratory cycle (0-100% of the cycle). We defined two morphological parameters for comparison of 4D-CT images in different respiratory phases: tumor-volume to lung-volume ratio and tumor-to-spinal cord distance. The RPO automatized the calculations (200 per patient) of these parameters for each phase of the respiratory cycle allowing to determine the optimal interval for RT.</p> <p>Results</p> <p>Lower lobe lung tumors not attached to the diaphragm presented with the largest motion with breathing. Maximum inspiration was considered the optimal phase for treatment in 4 patients (28.6%). In 7 patients (50%), however, the RPO showed a most favorable volumetric and spatial configuration in phases other than maximum inspiration. In 2 cases (14.4%) the RPO showed no benefit from gating. This tool was not conclusive in only one case.</p> <p>Conclusions</p> <p>The RPO software presented in this study can help to determine the optimal respiratory phase for gated RT based on a few simple morphological parameters. Easy to apply in daily routine, it may be a useful tool for selecting patients who might benefit from breathing adapted RT.</p> |
| first_indexed | 2024-04-13T10:02:23Z |
| format | Article |
| id | doaj.art-f136d74222114f4db97f6f9b1a9875c6 |
| institution | Directory Open Access Journal |
| issn | 1748-717X |
| language | English |
| last_indexed | 2024-04-13T10:02:23Z |
| publishDate | 2011-06-01 |
| publisher | BMC |
| record_format | Article |
| series | Radiation Oncology |
| spelling | doaj.art-f136d74222114f4db97f6f9b1a9875c62022-12-22T02:51:12ZengBMCRadiation Oncology1748-717X2011-06-01617810.1186/1748-717X-6-78Breathing adapted radiotherapy: a 4D gating software for lung cancerZaidi HabibAzria DavidFenoglietto PascalVinh-Hung VincentVock JacquelinePeguret NicolasWissmeyer MichaelRatib OsmanMiralbell Raymond<p>Abstract</p> <p>Purpose</p> <p>Physiological respiratory motion of tumors growing in the lung can be corrected with respiratory gating when treated with radiotherapy (RT). The optimal respiratory phase for beam-on may be assessed with a respiratory phase optimizer (RPO), a 4D image processing software developed with this purpose.</p> <p>Methods and Materials</p> <p>Fourteen patients with lung cancer were included in the study. Every patient underwent a 4D-CT providing ten datasets of ten phases of the respiratory cycle (0-100% of the cycle). We defined two morphological parameters for comparison of 4D-CT images in different respiratory phases: tumor-volume to lung-volume ratio and tumor-to-spinal cord distance. The RPO automatized the calculations (200 per patient) of these parameters for each phase of the respiratory cycle allowing to determine the optimal interval for RT.</p> <p>Results</p> <p>Lower lobe lung tumors not attached to the diaphragm presented with the largest motion with breathing. Maximum inspiration was considered the optimal phase for treatment in 4 patients (28.6%). In 7 patients (50%), however, the RPO showed a most favorable volumetric and spatial configuration in phases other than maximum inspiration. In 2 cases (14.4%) the RPO showed no benefit from gating. This tool was not conclusive in only one case.</p> <p>Conclusions</p> <p>The RPO software presented in this study can help to determine the optimal respiratory phase for gated RT based on a few simple morphological parameters. Easy to apply in daily routine, it may be a useful tool for selecting patients who might benefit from breathing adapted RT.</p>http://www.ro-journal.com/content/6/1/78Lung cancerradiotherapy4D-CTgating |
| spellingShingle | Zaidi Habib Azria David Fenoglietto Pascal Vinh-Hung Vincent Vock Jacqueline Peguret Nicolas Wissmeyer Michael Ratib Osman Miralbell Raymond Breathing adapted radiotherapy: a 4D gating software for lung cancer Radiation Oncology Lung cancer radiotherapy 4D-CT gating |
| title | Breathing adapted radiotherapy: a 4D gating software for lung cancer |
| title_full | Breathing adapted radiotherapy: a 4D gating software for lung cancer |
| title_fullStr | Breathing adapted radiotherapy: a 4D gating software for lung cancer |
| title_full_unstemmed | Breathing adapted radiotherapy: a 4D gating software for lung cancer |
| title_short | Breathing adapted radiotherapy: a 4D gating software for lung cancer |
| title_sort | breathing adapted radiotherapy a 4d gating software for lung cancer |
| topic | Lung cancer radiotherapy 4D-CT gating |
| url | http://www.ro-journal.com/content/6/1/78 |
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