Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

Intracellular IL-32 regulates mitochondrial metabolism, proliferation, and differentiation of malignant plasma cells

Summary: Interleukin-32 (IL-32) is a nonclassical cytokine expressed in cancers, inflammatory diseases, and infections. Its expression is regulated by two different oxygen sensing systems; HIF1α and cysteamine dioxygenase (ADO), indicating that IL-32 may be involved in the response to hypoxia. We he...

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Bibliographic Details
Main Authors: Kristin Roseth Aass, Robin Mjelle, Martin H. Kastnes, Synne S. Tryggestad, Luca M. van den Brink, Ingrid Aass Roseth, Marita Westhrin, Muhammad Zahoor, Siv H. Moen, Tonje M. Vikene Nedal, Glenn Buene, Kristine Misund, Anne-Marit Sponaas, Qianli Ma, Anders Sundan, Richard WJ. Groen, Tobias S. Slørdahl, Anders Waage, Therese Standal
Format: Article
Language:English
Published: Elsevier 2022-01-01
Series:iScience
Subjects:
Immunology
Cell biology
Cancer
Online Access:http://www.sciencedirect.com/science/article/pii/S2589004221015753

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