Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls
AbstractCovalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair. Many histone modifications have been characterized, yet understanding the intera...
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| Format: | Article |
| Language: | English |
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Oxford University Press
2023-02-01
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| Series: | G3: Genes, Genomes, Genetics |
| Online Access: | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad021 |
| _version_ | 1797788908778422272 |
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| author | Qihao Liu Lorraine Pillus Emily L Petty |
| author_facet | Qihao Liu Lorraine Pillus Emily L Petty |
| author_sort | Qihao Liu |
| collection | DOAJ |
| description |
AbstractCovalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair. Many histone modifications have been characterized, yet understanding the interactions between these and their combinatorial effects remains an active area of investigation, including dissecting functional interactions between enzymes mediating these modifications. In budding yeast, the histone acetyltransferase Gcn5 interacts with Rts1, a regulatory subunit of protein phosphatase 2A (PP2A). Implicated in the interaction is the potential for the dynamic phosphorylation of conserved residues on histone H2B and the Cse4 centromere-specific histone H3 variant.in silicoGCN5HOG1hog1Δgcn5Δgcn5Δ rts1ΔHOG1gcn5ΔGCN5 |
| first_indexed | 2024-03-13T01:43:14Z |
| format | Article |
| id | doaj.art-f13a66018b084fed80f0f0ffab3c650d |
| institution | Directory Open Access Journal |
| issn | 2160-1836 |
| language | English |
| last_indexed | 2024-03-13T01:43:14Z |
| publishDate | 2023-02-01 |
| publisher | Oxford University Press |
| record_format | Article |
| series | G3: Genes, Genomes, Genetics |
| spelling | doaj.art-f13a66018b084fed80f0f0ffab3c650d2023-07-03T11:13:06ZengOxford University PressG3: Genes, Genomes, Genetics2160-18362023-02-0113410.1093/g3journal/jkad021Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controlsQihao Liu0https://orcid.org/0000-0003-1753-5389Lorraine Pillus1https://orcid.org/0000-0002-8818-5227Emily L Petty2Department of Molecular Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-034, USADepartment of Molecular Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-034, USADepartment of Molecular Biology, University of California San Diego, 9500 Gilman Drive, La Jolla, CA 92093-034, USA AbstractCovalent modifications of chromatin regulate genomic structure and accessibility in diverse biological processes such as transcriptional regulation, cell cycle progression, and DNA damage repair. Many histone modifications have been characterized, yet understanding the interactions between these and their combinatorial effects remains an active area of investigation, including dissecting functional interactions between enzymes mediating these modifications. In budding yeast, the histone acetyltransferase Gcn5 interacts with Rts1, a regulatory subunit of protein phosphatase 2A (PP2A). Implicated in the interaction is the potential for the dynamic phosphorylation of conserved residues on histone H2B and the Cse4 centromere-specific histone H3 variant.in silicoGCN5HOG1hog1Δgcn5Δgcn5Δ rts1ΔHOG1gcn5ΔGCN5https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad021 |
| spellingShingle | Qihao Liu Lorraine Pillus Emily L Petty Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls G3: Genes, Genomes, Genetics |
| title | Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| title_full | Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| title_fullStr | Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| title_full_unstemmed | Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| title_short | Functional tug of war between kinases, phosphatases, and the Gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| title_sort | functional tug of war between kinases phosphatases and the gcn5 acetyltransferase in chromatin and cell cycle checkpoint controls |
| url | https://academic.oup.com/g3journal/article-lookup/doi/10.1093/g3journal/jkad021 |
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