Cinnamaldehyde Targets the LytTR DNA-Binding Domain of the Response Regulator AgrA to Attenuate Biofilm Formation of Listeria monocytogenes

Cinnamaldehyde Targets the LytTR DNA-Binding Domain of the Response Regulator AgrA to Attenuate Biofilm Formation of Listeria monocytogenes

ABSTRACT The Agr quorum sensing (QS) system is known to contribute to biofilm formation in Listeria monocytogenes. Cinnamaldehyde, a natural food preservative, is considered an inhibitor of Agr-mediated QS in L. monocytogenes. However, the exact mechanism by which cinnamaldehyde acts on Agr remains...

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Bibliographic Details
Main Authors: Xiaobing Jiang, Rui Kang, Tao Yu, Xiaojie Jiang, Hong Chen, Yiping Zhang, Yi Li, Hailei Wang
Format: Article
Language:English
Published: American Society for Microbiology 2023-06-01
Series:Microbiology Spectrum
Subjects:
Listeria monocytogenes
cinnamaldehyde
AgrA
LytTR DNA binding domain
biofilm formation
Online Access:https://journals.asm.org/doi/10.1128/spectrum.00300-23

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