FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50

FOXO3a Mediates Homologous Recombination Repair (HRR) via Transcriptional Activation of MRE11, BRCA1, BRIP1, and RAD50

To test whether homologous recombination repair (HRR) depends on FOXO3a, a cellular aging model of human dermal fibroblast (HDF) and tet-on flag-h-FOXO3a transgenic mice were studied. HDF cells transfected with over-expression of wt-h-FOXO3a increased the protein levels of MRE11, BRCA1, BRIP1, and R...

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Bibliographic Details
Main Authors: Gozde Inci, Madhuri Shende Warkad, Beom-Goo Kang, Na-Kyung Lee, Hong-Won Suh, Soon Sung Lim, Jaebong Kim, Sung-Chan Kim, Jae-Yong Lee
Format: Article
Language:English
Published: MDPI AG 2022-12-01
Series:Molecules
Subjects:
FOXO3a
homologous recombination repair
MRE11
BRCA1
BRIP1
RAD50
Online Access:https://www.mdpi.com/1420-3049/27/23/8623

Internet

https://www.mdpi.com/1420-3049/27/23/8623

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