Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix
Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer p...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2019-02-01
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| Series: | Journal of Investigative Surgery |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/08941939.2017.1399177 |
| _version_ | 1827817251118514176 |
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| author | Zhi Wang Jiuzuo Huang Ang Zeng Ming Wu Xiaojun Wang |
| author_facet | Zhi Wang Jiuzuo Huang Ang Zeng Ming Wu Xiaojun Wang |
| author_sort | Zhi Wang |
| collection | DOAJ |
| description | Various methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina. The effectiveness of the treatment was evaluated by the anatomic changes of vagina before and after treatment, and the sexual outcomes at 12-month after treatment. The procedure was safe with no intra-operative complications reported. The mean operation time was 1.7 ± 0.3 hours, with 11/16 patients had blood loss < 50 mL during surgery. Generally, epithelialization was observed in 2-week after treatment. At the 1-year follow-up visit, the mean vaginal width was increased significantly from 1.31 ± 0.4 cm before surgery to 4.13 ± 0.43 cm after surgery (p = 0.034). The vaginal length was also increased from 5.97 ± 0.59 cm to 9.25 ± 0.66 cm (p < 0.001). Majority of the patients (12/16) reported satisfactory sexual life. The use of ADM in vaginoplasty was a safe and effective procedure that provided satisfactory sexual function for patients with vaginal abnormalities after cervical cancer treatment. |
| first_indexed | 2024-03-12T00:31:46Z |
| format | Article |
| id | doaj.art-f13bb9979b1f45c4822f9fc5076e4f00 |
| institution | Directory Open Access Journal |
| issn | 0894-1939 1521-0553 |
| language | English |
| last_indexed | 2024-03-12T00:31:46Z |
| publishDate | 2019-02-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | Journal of Investigative Surgery |
| spelling | doaj.art-f13bb9979b1f45c4822f9fc5076e4f002023-09-15T10:12:28ZengTaylor & Francis GroupJournal of Investigative Surgery0894-19391521-05532019-02-0132218018510.1080/08941939.2017.13991771399177Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine CervixZhi Wang0Jiuzuo Huang1Ang Zeng2Ming Wu3Xiaojun Wang4Peking Union Medical College HospitalPeking Union Medical College HospitalPeking Union Medical College HospitalPeking Union Medical College HospitalPeking Union Medical College HospitalVarious methods are available for vaginoplasty, but many of them have the drawbacks including surgical complexity and postoperative pain at the donor site. We herein evaluated the outcomes of vaginoplasty using tissue-engineered biomaterial graft. This study included 16 early stage cervical cancer patients who received curative surgery in combination with radiotherapy. They underwent vaginoplasty with tissue-engineered biological material, acellular dermal matrix (ADM). After treatment, a vaginal dilator was advised to be used for 6 months to prevent contraction of vagina. The effectiveness of the treatment was evaluated by the anatomic changes of vagina before and after treatment, and the sexual outcomes at 12-month after treatment. The procedure was safe with no intra-operative complications reported. The mean operation time was 1.7 ± 0.3 hours, with 11/16 patients had blood loss < 50 mL during surgery. Generally, epithelialization was observed in 2-week after treatment. At the 1-year follow-up visit, the mean vaginal width was increased significantly from 1.31 ± 0.4 cm before surgery to 4.13 ± 0.43 cm after surgery (p = 0.034). The vaginal length was also increased from 5.97 ± 0.59 cm to 9.25 ± 0.66 cm (p < 0.001). Majority of the patients (12/16) reported satisfactory sexual life. The use of ADM in vaginoplasty was a safe and effective procedure that provided satisfactory sexual function for patients with vaginal abnormalities after cervical cancer treatment.http://dx.doi.org/10.1080/08941939.2017.1399177cervical cancervaginoplastysexual outcomeacellular dermal matrix |
| spellingShingle | Zhi Wang Jiuzuo Huang Ang Zeng Ming Wu Xiaojun Wang Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix Journal of Investigative Surgery cervical cancer vaginoplasty sexual outcome acellular dermal matrix |
| title | Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix |
| title_full | Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix |
| title_fullStr | Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix |
| title_full_unstemmed | Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix |
| title_short | Vaginoplasty with Acellular Dermal Matrix after Radical Resection for Carcinoma of the Uterine Cervix |
| title_sort | vaginoplasty with acellular dermal matrix after radical resection for carcinoma of the uterine cervix |
| topic | cervical cancer vaginoplasty sexual outcome acellular dermal matrix |
| url | http://dx.doi.org/10.1080/08941939.2017.1399177 |
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