G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence

G-MDSCs promote aging-related cardiac fibrosis by activating myofibroblasts and preventing senescence

Abstract Aging is one of the most prominent risk factors for heart failure. Myeloid-derived suppressor cells (MDSCs) accumulate in aged tissue and have been confirmed to be associated with various aging-related diseases. However, the role of MDSCs in the aging heart remains unknown. Through RNA-seq...

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Bibliographic Details
Main Authors:	Shu-Ning Sun, Shi-Hao Ni, Yue Li, Xin Liu, Jian-Ping Deng, Zi-Xin Chen, Huan Li, Wen-Jun Feng, Yu-Sheng Huang, Da-Nian Li, Shao-Xiang Xian, Zhong-Qi Yang, Ling-Jun Wang, Lu Lu
Format:	Article
Language:	English
Published:	Nature Publishing Group 2021-06-01
Series:	Cell Death and Disease
Online Access:	https://doi.org/10.1038/s41419-021-03874-7

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