Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin
Three porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the...
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MDPI AG
2022-10-01
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| Series: | Molecules |
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| Online Access: | https://www.mdpi.com/1420-3049/27/20/7045 |
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| author | Marta Glinka Katerina Filatova Justyna Kucińska-Lipka Tomáš Šopík Eva Domincová Bergerová Veronika Mikulcová Andrzej Wasik Vladimir Sedlařík |
| author_facet | Marta Glinka Katerina Filatova Justyna Kucińska-Lipka Tomáš Šopík Eva Domincová Bergerová Veronika Mikulcová Andrzej Wasik Vladimir Sedlařík |
| author_sort | Marta Glinka |
| collection | DOAJ |
| description | Three porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity. Depending on their actual composition, the materials exhibited varied efficacy for drug loading, as follows: 25.4 ± 2.2 μg/mg (matrices with 0.05% <i>w</i>/<i>v</i> of chitosan), 93 ± 13 μg/mg (with 0.08% <i>w</i>/<i>v</i> SiO<sub>2</sub> amikacin modified nanoparticles), and 96 ± 34 μg/mg (matrices without functional additives). An in vitro study confirmed extended release of the drug (amikacin, over 60 days), carried out in accordance with the mathematical Kosmyer–Pepas model for all the materials tested. The matrices were also evaluated for their effectiveness in inhibiting the growth of bacteria such as <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i>. Concurrent research was conducted on the transdermal absorption, morphology, elemental composition, and thermogravimetric properties of the released drug. |
| first_indexed | 2024-03-09T19:41:55Z |
| format | Article |
| id | doaj.art-f13c901f665246718cebc6717266640d |
| institution | Directory Open Access Journal |
| issn | 1420-3049 |
| language | English |
| last_indexed | 2024-03-09T19:41:55Z |
| publishDate | 2022-10-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Molecules |
| spelling | doaj.art-f13c901f665246718cebc6717266640d2023-11-24T01:36:19ZengMDPI AGMolecules1420-30492022-10-012720704510.3390/molecules27207045Antibacterial Porous Systems Based on Polylactide Loaded with AmikacinMarta Glinka0Katerina Filatova1Justyna Kucińska-Lipka2Tomáš Šopík3Eva Domincová Bergerová4Veronika Mikulcová5Andrzej Wasik6Vladimir Sedlařík7Department of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-233 Gdańsk, PolandCentre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tomáše Bati 5678 Street, 760 01 Zlín, Czech RepublicDepartment of Polymer Technology, Faculty of Chemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-233 Gdańsk, PolandCentre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tomáše Bati 5678 Street, 760 01 Zlín, Czech RepublicCentre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tomáše Bati 5678 Street, 760 01 Zlín, Czech RepublicCentre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tomáše Bati 5678 Street, 760 01 Zlín, Czech RepublicDepartment of Analytical Chemistry, Faculty of Chemistry, Gdańsk University of Technology, 11/12 G. Narutowicza Street, 80-233 Gdańsk, PolandCentre of Polymer Systems, University Institute, Tomas Bata University in Zlín, Tomáše Bati 5678 Street, 760 01 Zlín, Czech RepublicThree porous matrices based on poly(lactic acid) are proposed herein for the controlled release of amikacin. The materials were fabricated by the method of spraying a surface liquid. Description is given as to the possibility of employing a modifier, such as a silica nanocarrier, for prolonging the release of amikacin, in addition to using chitosan to improve the properties of the materials, e.g., stability and sorption capacity. Depending on their actual composition, the materials exhibited varied efficacy for drug loading, as follows: 25.4 ± 2.2 μg/mg (matrices with 0.05% <i>w</i>/<i>v</i> of chitosan), 93 ± 13 μg/mg (with 0.08% <i>w</i>/<i>v</i> SiO<sub>2</sub> amikacin modified nanoparticles), and 96 ± 34 μg/mg (matrices without functional additives). An in vitro study confirmed extended release of the drug (amikacin, over 60 days), carried out in accordance with the mathematical Kosmyer–Pepas model for all the materials tested. The matrices were also evaluated for their effectiveness in inhibiting the growth of bacteria such as <i>Staphylococcus aureus</i>, <i>Escherichia coli</i>, <i>Klebsiella pneumoniae</i>, and <i>Pseudomonas aeruginosa</i>. Concurrent research was conducted on the transdermal absorption, morphology, elemental composition, and thermogravimetric properties of the released drug.https://www.mdpi.com/1420-3049/27/20/7045poly(lactic acid)amikacindrug delivery systemsporous matricestissue engineering |
| spellingShingle | Marta Glinka Katerina Filatova Justyna Kucińska-Lipka Tomáš Šopík Eva Domincová Bergerová Veronika Mikulcová Andrzej Wasik Vladimir Sedlařík Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin Molecules poly(lactic acid) amikacin drug delivery systems porous matrices tissue engineering |
| title | Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin |
| title_full | Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin |
| title_fullStr | Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin |
| title_full_unstemmed | Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin |
| title_short | Antibacterial Porous Systems Based on Polylactide Loaded with Amikacin |
| title_sort | antibacterial porous systems based on polylactide loaded with amikacin |
| topic | poly(lactic acid) amikacin drug delivery systems porous matrices tissue engineering |
| url | https://www.mdpi.com/1420-3049/27/20/7045 |
| work_keys_str_mv | AT martaglinka antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT katerinafilatova antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT justynakucinskalipka antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT tomassopik antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT evadomincovabergerova antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT veronikamikulcova antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT andrzejwasik antibacterialporoussystemsbasedonpolylactideloadedwithamikacin AT vladimirsedlarik antibacterialporoussystemsbasedonpolylactideloadedwithamikacin |