Integrated transcriptomics and metabolomics analysis reveals that C3 and C5 are vital targets of DuZhi Wan in protecting against cerebral ischemic injury

Integrated transcriptomics and metabolomics analysis reveals that C3 and C5 are vital targets of DuZhi Wan in protecting against cerebral ischemic injury

Background/Aims: Duzhi Wan (DZW) has been extensively used in the prevention and treatment of ischemic stroke, but the mechanisms underlying its effects remain unclear. In this study, a combination of transcriptomics, metabolomics and network analysis was applied to identify the preventive mechanism...

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Bibliographic Details
Main Authors: Jing-yi Hou, Guang-zhao Cao, Liang-liang Tian, Rui Zhou, Yi Zhang, He Xu, Hong-wei Wu, Li-fang Wang, Hong-jun Yang, Jing-jing Zhang
Format: Article
Language:English
Published: Elsevier 2022-11-01
Series:Biomedicine & Pharmacotherapy
Subjects:
Cerebral ischemia/reperfusion injury
Duzhi Wan (DZW)
C3
C5
Neuroprotection
Antineuroinflammation
Online Access:http://www.sciencedirect.com/science/article/pii/S0753332222010927

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http://www.sciencedirect.com/science/article/pii/S0753332222010927

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