Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY
An acute toxicity test is one of the pre-clinical tests needed to determine the safety of the consumption of a product before clinical trials are carried out on humans. The purpose of this study was to confirm whether or not there was a toxic effect of jalembi juice probiotic drink (red guava, lemon...
| Main Authors: | , |
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| Format: | Article |
| Language: | Indonesian |
| Published: |
Universitas Jember
2023-12-01
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| Series: | Berkala Sainstek |
| Online Access: | https://jurnal.unej.ac.id/index.php/BST/article/view/34514 |
| _version_ | 1797362436386324480 |
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| author | Reza Anindita Afrinia Eka Sari |
| author_facet | Reza Anindita Afrinia Eka Sari |
| author_sort | Reza Anindita |
| collection | DOAJ |
| description | An acute toxicity test is one of the pre-clinical tests needed to determine the safety of the consumption of a product before clinical trials are carried out on humans. The purpose of this study was to confirm whether or not there was a toxic effect of jalembi juice probiotic drink (red guava, lemon, melon, beetroot) on male and female mice observed for 14 days. This research design is experimental. The samples in this study were jalembi probiotic juice drinks with Lactobacillus plantarum starter and 40 male and female ddY mice. This research procedure was carried out by giving jalembi juice as a test preparation with doses of 124, 640, 3200, and 16000 mg/kg BW as much as 0.59 ml in males and females mice. Data analysis was carried out with One-Way ANOVA. This study showed that the administration of probiotic drink jalembi juice with doses of 124, 640, 3200, and 16000 mg/KgBW as much as 0.59 ml did not cause death, changes in body weight, and clinical symptoms in all test animals. It can be concluded that the probiotic drink jalembi juice is categorized as practically non-toxic (> 15 g/KgBW) or passes pre-clinical testing as a safe drink for consumption. |
| first_indexed | 2024-03-08T16:07:56Z |
| format | Article |
| id | doaj.art-f13eacbcaaa34b9192cbfb8910d38008 |
| institution | Directory Open Access Journal |
| issn | 2339-0069 |
| language | Indonesian |
| last_indexed | 2024-03-08T16:07:56Z |
| publishDate | 2023-12-01 |
| publisher | Universitas Jember |
| record_format | Article |
| series | Berkala Sainstek |
| spelling | doaj.art-f13eacbcaaa34b9192cbfb8910d380082024-01-08T05:08:28ZindUniversitas JemberBerkala Sainstek2339-00692023-12-0111418719310.19184/bst.v11i4.3451434514Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddYReza Anindita0Afrinia Eka Sari1Prodi S-1 Farmasi, STIKes Mitra Keluarga, Jl. Pengasinan, Rw. Semut, Bekasi, Jawa Barat, IndonesiaProdi S-1 Gizi, STIKes Mitra Keluarga, Jl. Pengasinan, Rw. Semut, Bekasi, Jawa Barat, IndonesiaAn acute toxicity test is one of the pre-clinical tests needed to determine the safety of the consumption of a product before clinical trials are carried out on humans. The purpose of this study was to confirm whether or not there was a toxic effect of jalembi juice probiotic drink (red guava, lemon, melon, beetroot) on male and female mice observed for 14 days. This research design is experimental. The samples in this study were jalembi probiotic juice drinks with Lactobacillus plantarum starter and 40 male and female ddY mice. This research procedure was carried out by giving jalembi juice as a test preparation with doses of 124, 640, 3200, and 16000 mg/kg BW as much as 0.59 ml in males and females mice. Data analysis was carried out with One-Way ANOVA. This study showed that the administration of probiotic drink jalembi juice with doses of 124, 640, 3200, and 16000 mg/KgBW as much as 0.59 ml did not cause death, changes in body weight, and clinical symptoms in all test animals. It can be concluded that the probiotic drink jalembi juice is categorized as practically non-toxic (> 15 g/KgBW) or passes pre-clinical testing as a safe drink for consumption.https://jurnal.unej.ac.id/index.php/BST/article/view/34514 |
| spellingShingle | Reza Anindita Afrinia Eka Sari Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY Berkala Sainstek |
| title | Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY |
| title_full | Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY |
| title_fullStr | Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY |
| title_full_unstemmed | Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY |
| title_short | Acute Toxicity Test of Jalembi Probiotic Beverages on Mice ddY |
| title_sort | acute toxicity test of jalembi probiotic beverages on mice ddy |
| url | https://jurnal.unej.ac.id/index.php/BST/article/view/34514 |
| work_keys_str_mv | AT rezaanindita acutetoxicitytestofjalembiprobioticbeveragesonmiceddy AT afriniaekasari acutetoxicitytestofjalembiprobioticbeveragesonmiceddy |