Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease
Abstract We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features...
Main Authors: | , , , , , , |
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Format: | Article |
Language: | English |
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Nature Portfolio
2022-04-01
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Series: | npj Parkinson's Disease |
Online Access: | https://doi.org/10.1038/s41531-022-00300-3 |
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author | Pedro A. B. Pereira Drupad K. Trivedi Justin Silverman Ilhan Cem Duru Lars Paulin Petri Auvinen Filip Scheperjans |
author_facet | Pedro A. B. Pereira Drupad K. Trivedi Justin Silverman Ilhan Cem Duru Lars Paulin Petri Auvinen Filip Scheperjans |
author_sort | Pedro A. B. Pereira |
collection | DOAJ |
description | Abstract We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD. |
first_indexed | 2024-03-11T13:51:45Z |
format | Article |
id | doaj.art-f140344979fd47ddbf19c1cd4cbae81c |
institution | Directory Open Access Journal |
issn | 2373-8057 |
language | English |
last_indexed | 2024-03-11T13:51:45Z |
publishDate | 2022-04-01 |
publisher | Nature Portfolio |
record_format | Article |
series | npj Parkinson's Disease |
spelling | doaj.art-f140344979fd47ddbf19c1cd4cbae81c2023-11-02T08:30:15ZengNature Portfolionpj Parkinson's Disease2373-80572022-04-018111710.1038/s41531-022-00300-3Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s diseasePedro A. B. Pereira0Drupad K. Trivedi1Justin Silverman2Ilhan Cem Duru3Lars Paulin4Petri Auvinen5Filip Scheperjans6Department of Neurology, Helsinki University Hospital, and Clinicum, University of HelsinkiManchester Institute of Biotechnology, The University of ManchesterCollege of Information Science and Technology, Department of Statistics, and Institute for Computational and Data Science, Penn State UniversityInstitute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of HelsinkiInstitute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of HelsinkiInstitute of Biotechnology, DNA Sequencing and Genomics Laboratory, University of HelsinkiDepartment of Neurology, Helsinki University Hospital, and Clinicum, University of HelsinkiAbstract We aimed to investigate the link between serum metabolites, gut bacterial community composition, and clinical variables in Parkinson’s disease (PD) and healthy control subjects (HC). A total of 124 subjects were part of the study (63 PD patients and 61 HC subjects). 139 metabolite features were found to be predictive between the PD and Control groups. No associations were found between metabolite features and within-PD clinical variables. The results suggest alterations in serum metabolite profiles in PD, and the results of correlation analysis between metabolite features and microbiota suggest that several bacterial taxa are associated with altered lipid and energy metabolism in PD.https://doi.org/10.1038/s41531-022-00300-3 |
spellingShingle | Pedro A. B. Pereira Drupad K. Trivedi Justin Silverman Ilhan Cem Duru Lars Paulin Petri Auvinen Filip Scheperjans Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease npj Parkinson's Disease |
title | Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease |
title_full | Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease |
title_fullStr | Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease |
title_full_unstemmed | Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease |
title_short | Multiomics implicate gut microbiota in altered lipid and energy metabolism in Parkinson’s disease |
title_sort | multiomics implicate gut microbiota in altered lipid and energy metabolism in parkinson s disease |
url | https://doi.org/10.1038/s41531-022-00300-3 |
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