Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies
Objective: This study aims to clarify the incidence rate of temporomandibular joint disease in patients with mental disorders.Methods: Data extracted from the Psychiatric Genomics Consortium and FinnGen databases employed the Mendelian Randomization (MR) method to assess the associations of three ne...
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2024-03-01
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| Series: | Frontiers in Genetics |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fgene.2024.1365596/full |
| _version_ | 1797269080363761664 |
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| author | Xueqiang Wu Zefang Li Yiping Cui Zhaojun Yan Tingting Lu Song Cui |
| author_facet | Xueqiang Wu Zefang Li Yiping Cui Zhaojun Yan Tingting Lu Song Cui |
| author_sort | Xueqiang Wu |
| collection | DOAJ |
| description | Objective: This study aims to clarify the incidence rate of temporomandibular joint disease in patients with mental disorders.Methods: Data extracted from the Psychiatric Genomics Consortium and FinnGen databases employed the Mendelian Randomization (MR) method to assess the associations of three neurodevelopmental disorders (NDDs)—Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Tourette’s Disorder (TD)—as exposure factors with Temporomandibular Disorder (TMD). The analysis used a two-sample MR design, employing the Inverse Variance Weighted (IVW) method to evaluate the relationships between these disorders and Temporomandibular Disorder. Sensitivity analysis and heterogeneity assessments were conducted. Potential confounding factors like low birth weight, childhood obesity, and body mass index were controlled for.Results: The study found that ADHD significantly increased the risks for TMD (OR = 1.2342, 95%CI (1.1448–1.3307), p < 0.00001), TMD (including avohilmo) (OR = 1.1244, 95%CI (1.0643–1.1880), p = 0.00003), TMD-related pain (OR = 1.1590, 95%CI (1.0964–1.2252), p < 0.00001), and TMD-related muscular pain associated with fibromyalgia (OR = 1.1815, 95%CI (1.1133–1.2538), p < 0.00001), while other disorders did not show significant causal relationships.Conclusion: This study reveals the elevated risk of various TMD aspects due to ADHD. Furthermore, we discuss the link between low vitamin D levels ADHD and TMD. Future research should address these limitations and delve further into the complex interactions between ADHD, ASD, TD, and TMD. |
| first_indexed | 2024-04-25T01:42:41Z |
| format | Article |
| id | doaj.art-f1405b91e65c49d68b60f080d40f956d |
| institution | Directory Open Access Journal |
| issn | 1664-8021 |
| language | English |
| last_indexed | 2024-04-25T01:42:41Z |
| publishDate | 2024-03-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Genetics |
| spelling | doaj.art-f1405b91e65c49d68b60f080d40f956d2024-03-08T04:45:45ZengFrontiers Media S.A.Frontiers in Genetics1664-80212024-03-011510.3389/fgene.2024.13655961365596Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studiesXueqiang Wu0Zefang Li1Yiping Cui2Zhaojun Yan3Tingting Lu4Song Cui5Department of Health Science, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaAffiliated Hospital of Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaDepartment of the First Clinical Medicine, Shandong University of Traditional Chinese Medicine, Jinan, ChinaObjective: This study aims to clarify the incidence rate of temporomandibular joint disease in patients with mental disorders.Methods: Data extracted from the Psychiatric Genomics Consortium and FinnGen databases employed the Mendelian Randomization (MR) method to assess the associations of three neurodevelopmental disorders (NDDs)—Attention-Deficit/Hyperactivity Disorder (ADHD), Autism Spectrum Disorder (ASD), and Tourette’s Disorder (TD)—as exposure factors with Temporomandibular Disorder (TMD). The analysis used a two-sample MR design, employing the Inverse Variance Weighted (IVW) method to evaluate the relationships between these disorders and Temporomandibular Disorder. Sensitivity analysis and heterogeneity assessments were conducted. Potential confounding factors like low birth weight, childhood obesity, and body mass index were controlled for.Results: The study found that ADHD significantly increased the risks for TMD (OR = 1.2342, 95%CI (1.1448–1.3307), p < 0.00001), TMD (including avohilmo) (OR = 1.1244, 95%CI (1.0643–1.1880), p = 0.00003), TMD-related pain (OR = 1.1590, 95%CI (1.0964–1.2252), p < 0.00001), and TMD-related muscular pain associated with fibromyalgia (OR = 1.1815, 95%CI (1.1133–1.2538), p < 0.00001), while other disorders did not show significant causal relationships.Conclusion: This study reveals the elevated risk of various TMD aspects due to ADHD. Furthermore, we discuss the link between low vitamin D levels ADHD and TMD. Future research should address these limitations and delve further into the complex interactions between ADHD, ASD, TD, and TMD.https://www.frontiersin.org/articles/10.3389/fgene.2024.1365596/fullneurodevelopmental disorderstemporomandibular disorderMendelian randomizationattention deficit and hyperactivity disordertourette disorderaustim spectrum disorder |
| spellingShingle | Xueqiang Wu Zefang Li Yiping Cui Zhaojun Yan Tingting Lu Song Cui Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies Frontiers in Genetics neurodevelopmental disorders temporomandibular disorder Mendelian randomization attention deficit and hyperactivity disorder tourette disorder austim spectrum disorder |
| title | Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies |
| title_full | Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies |
| title_fullStr | Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies |
| title_full_unstemmed | Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies |
| title_short | Neurodevelopmental disorders as a risk factor for temporomandibular disorder: evidence from Mendelian randomization studies |
| title_sort | neurodevelopmental disorders as a risk factor for temporomandibular disorder evidence from mendelian randomization studies |
| topic | neurodevelopmental disorders temporomandibular disorder Mendelian randomization attention deficit and hyperactivity disorder tourette disorder austim spectrum disorder |
| url | https://www.frontiersin.org/articles/10.3389/fgene.2024.1365596/full |
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