Synthesis of Alkyne-Substituted Dihydropyrrolones as Bacterial Quorum-Sensing Inhibitors of <i>Pseudomonas aeruginosa</i>

Synthesis of Alkyne-Substituted Dihydropyrrolones as Bacterial Quorum-Sensing Inhibitors of <i>Pseudomonas aeruginosa</i>

The Quorum-sensing system in <i>Pseudomonas aeruginosa</i> is responsible for the pathogenicity and the production of virulence factors and biofilm formation. Dihydropyrrolones were previously found to act as inhibitors of QS-dependent bacterial phenotypes. In this study, a range of dihy...

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Bibliographic Details
Main Authors: Basmah Almohaywi, Tsz Tin Yu, George Iskander, Shekh Sabir, Mohan Bhadbhade, David StC. Black, Naresh Kumar
Format: Article
Language:English
Published: MDPI AG 2022-01-01
Series:Antibiotics
Subjects:
quorum sensing
alkyne synthesis
<i>Pseudomonas aeruginosa</i>
dihydropyrrolones
Online Access:https://www.mdpi.com/2079-6382/11/2/151

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