Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents
Abstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenti...
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| Format: | Article |
| Language: | English |
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BMC
2021-11-01
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| Series: | BMC Psychiatry |
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| Online Access: | https://doi.org/10.1186/s12888-021-03576-6 |
| _version_ | 1798033205069086720 |
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| author | Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu |
| author_facet | Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu |
| author_sort | Lan Guo |
| collection | DOAJ |
| description | Abstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples. |
| first_indexed | 2024-04-11T20:25:29Z |
| format | Article |
| id | doaj.art-f1418aaed45a47199ab794b8272c7b78 |
| institution | Directory Open Access Journal |
| issn | 1471-244X |
| language | English |
| last_indexed | 2024-04-11T20:25:29Z |
| publishDate | 2021-11-01 |
| publisher | BMC |
| record_format | Article |
| series | BMC Psychiatry |
| spelling | doaj.art-f1418aaed45a47199ab794b8272c7b782022-12-22T04:04:40ZengBMCBMC Psychiatry1471-244X2021-11-0121111110.1186/s12888-021-03576-6Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescentsLan Guo0Wanxin Wang1Yangfeng Guo2Xueying Du3Guangduoji Shi4Ciyong Lu5Department of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityHealth Promotion Centre for Primary and Secondary Schools of Guangzhou MunicipalityHealth Promotion Centre for Primary and Secondary Schools of Guangzhou MunicipalityDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityDepartment of Medical Statistics and Epidemiology, School of Public Health, Sun Yat-sen UniversityAbstract Background Genetic factors may interplay with environmental stressors to contribute to risks of depressive symptoms. This study aimed to investigate the association of FKBP5 polymorphisms and DNA methylation with depressive symptoms among Chinese adolescents, considering the role of parenting style. Methods This study used a nested case-control study design based on a cohort study, and the case (n = 120) and control groups (n = 118) were matched with age. Depressive symptoms, parenting style, and other demographics were measured. Fourteen potential polymorphisms and one promoter region in the FKBP5 gene were selected for genotyping and methylation analysis. Results In the adjusted models, a significant association between FKBP5 rs7757037 and depressive symptoms was found in the codominant model (AG vs. GG; adjusted odds ratio [AOR] = 2.56, 95% CI = 1.13–5.78) and dominant model (AA+AG vs. GG; AOR = 2.38, 95% CI = 1.11–5.120); rs2817032 and rs2817035 polymorphisms were associated with depressive symptoms in the codominant model and dominant model. Significant interactions between rs7757037 and the father’s parenting style were found in the codominant model (P = 0.043) and dominant model (P = 0.043), but the gene-environment interactions were not significant after correcting for multiple testing. Moreover, the significant main effects of FKBP5 methylation status on depressive symptoms were not observed, and there was no significant interaction between FKBP5 methylation status and parenting style on depressive symptoms. Conclusions Further studies are required to confirm the effect of FKBP5 polymorphisms and methylation as well as their interactions with parenting styles in larger samples.https://doi.org/10.1186/s12888-021-03576-6FKBP5 polymorphism and methylationParenting styleDepressive symptomsChinese adolescentsNested case-control study |
| spellingShingle | Lan Guo Wanxin Wang Yangfeng Guo Xueying Du Guangduoji Shi Ciyong Lu Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents BMC Psychiatry FKBP5 polymorphism and methylation Parenting style Depressive symptoms Chinese adolescents Nested case-control study |
| title | Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents |
| title_full | Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents |
| title_fullStr | Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents |
| title_full_unstemmed | Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents |
| title_short | Associations of FKBP5 polymorphisms and methylation and parenting style with depressive symptoms among Chinese adolescents |
| title_sort | associations of fkbp5 polymorphisms and methylation and parenting style with depressive symptoms among chinese adolescents |
| topic | FKBP5 polymorphism and methylation Parenting style Depressive symptoms Chinese adolescents Nested case-control study |
| url | https://doi.org/10.1186/s12888-021-03576-6 |
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