Altered Brain Microstate Dynamics in Adolescents with Narcolepsy
Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In...
| Main Authors: | , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2016-08-01
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| Series: | Frontiers in Human Neuroscience |
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| Online Access: | https://www.frontiersin.org/article/10.3389/fnhum.2016.00369/full |
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| author | Natasha M. Drissi Natasha M. Drissi Attila Szakács Suzanne T. Witt Anna Wretman Martin Ulander Henriettae Ståhlbrandt Niklas Darin Tove Hallböök Anne-Marie Landtblom Anne-Marie Landtblom Maria Engström Maria Engström |
| author_facet | Natasha M. Drissi Natasha M. Drissi Attila Szakács Suzanne T. Witt Anna Wretman Martin Ulander Henriettae Ståhlbrandt Niklas Darin Tove Hallböök Anne-Marie Landtblom Anne-Marie Landtblom Maria Engström Maria Engström |
| author_sort | Natasha M. Drissi |
| collection | DOAJ |
| description | Narcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition to hypothalamic and thalamic dysfunction they showed aberrant prefrontal perfusion and glucose metabolism in narcolepsy. Given these findings in brain structure and metabolism in narcolepsy, we anticipated that changes in functional magnetic resonance imaging (fMRI) resting state network (RSN) dynamics might also be apparent in patients with narcolepsy. The objective of this study was to investigate and describe brain microstate activity in adolescents with narcolepsy and correlate these to RSNs using simultaneous fMRI and electroencephalography (EEG). Sixteen adolescents (ages 13–20) with a confirmed diagnosis of narcolepsy were recruited and compared to age-matched healthy controls. Simultaneous EEG and fMRI data were collected during 10 min of wakeful rest. EEG data were analyzed for microstates, which are discrete epochs of stable global brain states obtained from topographical EEG analysis. Functional MRI data were analyzed for RSNs. Data showed that narcolepsy patients were less likely than controls to spend time in a microstate which we found to be related to the default mode network and may suggest a disruption of this network that is disease specific. We concluded that adolescents with narcolepsy have altered resting state brain dynamics. |
| first_indexed | 2024-12-13T00:06:27Z |
| format | Article |
| id | doaj.art-f141ec35999d430681d4b872ff678f3d |
| institution | Directory Open Access Journal |
| issn | 1662-5161 |
| language | English |
| last_indexed | 2024-12-13T00:06:27Z |
| publishDate | 2016-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Human Neuroscience |
| spelling | doaj.art-f141ec35999d430681d4b872ff678f3d2022-12-22T00:06:15ZengFrontiers Media S.A.Frontiers in Human Neuroscience1662-51612016-08-011010.3389/fnhum.2016.00369186894Altered Brain Microstate Dynamics in Adolescents with NarcolepsyNatasha M. Drissi0Natasha M. Drissi1Attila Szakács2Suzanne T. Witt3Anna Wretman4Martin Ulander5Henriettae Ståhlbrandt6Niklas Darin7Tove Hallböök8Anne-Marie Landtblom9Anne-Marie Landtblom10Maria Engström11Maria Engström12Department of Medical and Health Sciences (IMH), Linköping UniversityLinköping, SwedenCenter for Medical Image Science and Visualization (CMIV), Linköping UniversityLinköping, SwedenDepartment of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgGothenburg, SwedenCenter for Medical Image Science and Visualization (CMIV), Linköping UniversityLinköping, SwedenDepartment of Behavioral Science and Learning, Linköping UniversityLinköping, SwedenDepartment of Clinical and Experimental Medicine, Linköping UniversityLinköping, SwedenDepartment of Radiology, Medical Diagnostics, Highland HospitalEksjö, SwedenDepartment of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgGothenburg, SwedenDepartment of Paediatrics, Institute of Clinical Sciences, Sahlgrenska Academy, University of GothenburgGothenburg, SwedenDepartment of Clinical and Experimental Medicine, Linköping UniversityLinköping, SwedenDepartment of Neurology, Uppsala UniversityUppsala, SwedenDepartment of Medical and Health Sciences (IMH), Linköping UniversityLinköping, SwedenCenter for Medical Image Science and Visualization (CMIV), Linköping UniversityLinköping, SwedenNarcolepsy is a chronic sleep disorder caused by a loss of hypocretin-1 producing neurons in the hypothalamus. Previous neuroimaging studies have investigated brain function in narcolepsy during rest using positron emission tomography (PET) and single photon emission computed tomography (SPECT). In addition to hypothalamic and thalamic dysfunction they showed aberrant prefrontal perfusion and glucose metabolism in narcolepsy. Given these findings in brain structure and metabolism in narcolepsy, we anticipated that changes in functional magnetic resonance imaging (fMRI) resting state network (RSN) dynamics might also be apparent in patients with narcolepsy. The objective of this study was to investigate and describe brain microstate activity in adolescents with narcolepsy and correlate these to RSNs using simultaneous fMRI and electroencephalography (EEG). Sixteen adolescents (ages 13–20) with a confirmed diagnosis of narcolepsy were recruited and compared to age-matched healthy controls. Simultaneous EEG and fMRI data were collected during 10 min of wakeful rest. EEG data were analyzed for microstates, which are discrete epochs of stable global brain states obtained from topographical EEG analysis. Functional MRI data were analyzed for RSNs. Data showed that narcolepsy patients were less likely than controls to spend time in a microstate which we found to be related to the default mode network and may suggest a disruption of this network that is disease specific. We concluded that adolescents with narcolepsy have altered resting state brain dynamics.https://www.frontiersin.org/article/10.3389/fnhum.2016.00369/fullnarcolepsydefault mode networkfunctional magnetic resonance imaging (fMRI)electroencephalography (EEG)microstatesresting state networks |
| spellingShingle | Natasha M. Drissi Natasha M. Drissi Attila Szakács Suzanne T. Witt Anna Wretman Martin Ulander Henriettae Ståhlbrandt Niklas Darin Tove Hallböök Anne-Marie Landtblom Anne-Marie Landtblom Maria Engström Maria Engström Altered Brain Microstate Dynamics in Adolescents with Narcolepsy Frontiers in Human Neuroscience narcolepsy default mode network functional magnetic resonance imaging (fMRI) electroencephalography (EEG) microstates resting state networks |
| title | Altered Brain Microstate Dynamics in Adolescents with Narcolepsy |
| title_full | Altered Brain Microstate Dynamics in Adolescents with Narcolepsy |
| title_fullStr | Altered Brain Microstate Dynamics in Adolescents with Narcolepsy |
| title_full_unstemmed | Altered Brain Microstate Dynamics in Adolescents with Narcolepsy |
| title_short | Altered Brain Microstate Dynamics in Adolescents with Narcolepsy |
| title_sort | altered brain microstate dynamics in adolescents with narcolepsy |
| topic | narcolepsy default mode network functional magnetic resonance imaging (fMRI) electroencephalography (EEG) microstates resting state networks |
| url | https://www.frontiersin.org/article/10.3389/fnhum.2016.00369/full |
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