The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients
Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesio...
| Main Authors: | , , , , |
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| Format: | Article |
| Language: | English |
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Associação Brasileira de Divulgação Científica
2005-09-01
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| Series: | Brazilian Journal of Medical and Biological Research |
| Subjects: | |
| Online Access: | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900008 |
| _version_ | 1819229597630201856 |
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| author | S.R. Coimbra S.H. Lage L. Brandizzi V. Yoshida P.L. da Luz |
| author_facet | S.R. Coimbra S.H. Lage L. Brandizzi V. Yoshida P.L. da Luz |
| author_sort | S.R. Coimbra |
| collection | DOAJ |
| description | Although red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender. |
| first_indexed | 2024-12-23T11:15:42Z |
| format | Article |
| id | doaj.art-f14205ae5c434860b8ed13807dc0e72c |
| institution | Directory Open Access Journal |
| issn | 0100-879X 1414-431X |
| language | English |
| last_indexed | 2024-12-23T11:15:42Z |
| publishDate | 2005-09-01 |
| publisher | Associação Brasileira de Divulgação Científica |
| record_format | Article |
| series | Brazilian Journal of Medical and Biological Research |
| spelling | doaj.art-f14205ae5c434860b8ed13807dc0e72c2022-12-21T17:49:14ZengAssociação Brasileira de Divulgação CientíficaBrazilian Journal of Medical and Biological Research0100-879X1414-431X2005-09-013891339134710.1590/S0100-879X2005000900008The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patientsS.R. CoimbraS.H. LageL. BrandizziV. YoshidaP.L. da LuzAlthough red wine (RW) reduces cardiovascular risk, the mechanisms underlying the effect have not been identified. Correction of endothelial dysfunction by RW flavonoids could be one mechanism. We measured brachial artery reactivity by high-resolution ultrasonography, plasma lipids, glucose, adhesion molecules (ICAM-1 and VCAM), and platelet function in 16 hypercholesterolemic individuals (8 men and 8 women; mean age 51.6 ± 8.1 years) without other risk factors. Twenty-four normal subjects were used as controls for vascular reactivity. Subjects randomly received RW, 250 ml/day, or purple grape juice (GJ), 500 ml/day, for 14 days with an equal wash-out period. At baseline, all 16 subjects were hypercholesterolemic (mean LDL = 181.0 ± 28.7 mg/dl) but HDL, triglycerides, glucose, adhesion molecules, and platelet function were within normal limits. Brachial artery flow-mediated dilation was significantly decreased compared to controls (9.0 ± 7.1 vs 12.1 ± 4.5%; P < 0.05) and increased with both GJ (10.1 ± 7.1 before vs 16.9 ± 6.7% after: P < 0.05) and RW (10.1 ± 6.4 before vs 15.6 ± 4.6% after; P < 0.05). RW, but not GJ, also significantly increased endothelium-independent vasodilation (17.0 ± 8.6 before vs 23.0 ± 12.0% after; P < 0.01). GJ reduced ICAM-1 but not VCAM and RW had no effect on either molecule. No significant alterations were observed in plasma lipids, glucose or platelet aggregability with RW or GJ. Both RW and GJ similarly improved flow-mediated dilation, but RW also enhanced endothelium-independent vasodilation in hypercholesterolemic patients despite the increased plasma cholesterol. Thus, we conclude that GJ may protect against coronary artery disease without the additional negative effects of alcohol despite the gender.http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900008AtherosclerosisEndothelial functionFlavonoidsAlcoholRed wine and grape juiceBrachial artery dilation |
| spellingShingle | S.R. Coimbra S.H. Lage L. Brandizzi V. Yoshida P.L. da Luz The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients Brazilian Journal of Medical and Biological Research Atherosclerosis Endothelial function Flavonoids Alcohol Red wine and grape juice Brachial artery dilation |
| title | The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| title_full | The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| title_fullStr | The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| title_full_unstemmed | The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| title_short | The action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| title_sort | action of red wine and purple grape juice on vascular reactivity is independent of plasma lipids in hypercholesterolemic patients |
| topic | Atherosclerosis Endothelial function Flavonoids Alcohol Red wine and grape juice Brachial artery dilation |
| url | http://www.scielo.br/scielo.php?script=sci_arttext&pid=S0100-879X2005000900008 |
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