Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death
Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent lipid peroxidation. As major sites of iron utilization and master regulators of oxidative metabolism, mitochondria are the main source of reactive oxygen species (ROS) and, thus, play a role in this type of RC...
| Main Authors: | , , , , , |
|---|---|
| Format: | Article |
| Language: | English |
| Published: |
MDPI AG
2020-06-01
|
| Series: | Cells |
| Subjects: | |
| Online Access: | https://www.mdpi.com/2073-4409/9/6/1505 |
| _version_ | 1827714592880459776 |
|---|---|
| author | Anna Martina Battaglia Roberta Chirillo Ilenia Aversa Alessandro Sacco Francesco Costanzo Flavia Biamonte |
| author_facet | Anna Martina Battaglia Roberta Chirillo Ilenia Aversa Alessandro Sacco Francesco Costanzo Flavia Biamonte |
| author_sort | Anna Martina Battaglia |
| collection | DOAJ |
| description | Ferroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent lipid peroxidation. As major sites of iron utilization and master regulators of oxidative metabolism, mitochondria are the main source of reactive oxygen species (ROS) and, thus, play a role in this type of RCD. Ferroptosis is, indeed, associated with severe damage in mitochondrial morphology, bioenergetics, and metabolism. Furthermore, dysregulation of mitochondrial metabolism is considered a biochemical feature of neurodegenerative diseases linked to ferroptosis. Whether mitochondrial dysfunction can, per se, initiate ferroptosis and whether mitochondrial function in ferroptosis is context-dependent are still under debate. Cancer cells accumulate high levels of iron and ROS to promote their metabolic activity and growth. Of note, cancer cell metabolic rewiring is often associated with acquired sensitivity to ferroptosis. This strongly suggests that ferroptosis may act as an adaptive response to metabolic imbalance and, thus, may constitute a new promising way to eradicate malignant cells. Here, we review the current literature on the role of mitochondria in ferroptosis, and we discuss opportunities to potentially use mitochondria-mediated ferroptosis as a new strategy for cancer therapy. |
| first_indexed | 2024-03-10T19:00:47Z |
| format | Article |
| id | doaj.art-f14227e1058a435aa6a0956a8064865c |
| institution | Directory Open Access Journal |
| issn | 2073-4409 |
| language | English |
| last_indexed | 2024-03-10T19:00:47Z |
| publishDate | 2020-06-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Cells |
| spelling | doaj.art-f14227e1058a435aa6a0956a8064865c2023-11-20T04:28:47ZengMDPI AGCells2073-44092020-06-0196150510.3390/cells9061505Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell DeathAnna Martina Battaglia0Roberta Chirillo1Ilenia Aversa2Alessandro Sacco3Francesco Costanzo4Flavia Biamonte5Department of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyDepartment of Experimental and Clinical Medicine, “Magna Graecia” University of Catanzaro, 88100 Catanzaro, ItalyFerroptosis is a new type of oxidative regulated cell death (RCD) driven by iron-dependent lipid peroxidation. As major sites of iron utilization and master regulators of oxidative metabolism, mitochondria are the main source of reactive oxygen species (ROS) and, thus, play a role in this type of RCD. Ferroptosis is, indeed, associated with severe damage in mitochondrial morphology, bioenergetics, and metabolism. Furthermore, dysregulation of mitochondrial metabolism is considered a biochemical feature of neurodegenerative diseases linked to ferroptosis. Whether mitochondrial dysfunction can, per se, initiate ferroptosis and whether mitochondrial function in ferroptosis is context-dependent are still under debate. Cancer cells accumulate high levels of iron and ROS to promote their metabolic activity and growth. Of note, cancer cell metabolic rewiring is often associated with acquired sensitivity to ferroptosis. This strongly suggests that ferroptosis may act as an adaptive response to metabolic imbalance and, thus, may constitute a new promising way to eradicate malignant cells. Here, we review the current literature on the role of mitochondria in ferroptosis, and we discuss opportunities to potentially use mitochondria-mediated ferroptosis as a new strategy for cancer therapy.https://www.mdpi.com/2073-4409/9/6/1505mitochondriaferroptosiscancercell deathironROS |
| spellingShingle | Anna Martina Battaglia Roberta Chirillo Ilenia Aversa Alessandro Sacco Francesco Costanzo Flavia Biamonte Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death Cells mitochondria ferroptosis cancer cell death iron ROS |
| title | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death |
| title_full | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death |
| title_fullStr | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death |
| title_full_unstemmed | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death |
| title_short | Ferroptosis and Cancer: Mitochondria Meet the “Iron Maiden” Cell Death |
| title_sort | ferroptosis and cancer mitochondria meet the iron maiden cell death |
| topic | mitochondria ferroptosis cancer cell death iron ROS |
| url | https://www.mdpi.com/2073-4409/9/6/1505 |
| work_keys_str_mv | AT annamartinabattaglia ferroptosisandcancermitochondriameettheironmaidencelldeath AT robertachirillo ferroptosisandcancermitochondriameettheironmaidencelldeath AT ileniaaversa ferroptosisandcancermitochondriameettheironmaidencelldeath AT alessandrosacco ferroptosisandcancermitochondriameettheironmaidencelldeath AT francescocostanzo ferroptosisandcancermitochondriameettheironmaidencelldeath AT flaviabiamonte ferroptosisandcancermitochondriameettheironmaidencelldeath |