False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis
BackgroundThe long‐term association between the status of the false lumen and poor patient outcomes in acute aortic dissection (AAD) remains unclear. This systematic review and meta‐analysis investigated whether the status of the false lumen was a predictor of poor long‐term survival in AAD. Methods...
| Main Authors: | , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
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Wiley
2016-05-01
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| Series: | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| Subjects: | |
| Online Access: | https://www.ahajournals.org/doi/10.1161/JAHA.115.003172 |
| _version_ | 1819178682379403264 |
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| author | Dongze Li Lei Ye Yarong He Xiaoping Cao Jining Liu Wu Zhong Linghong Cao Rui Zeng Zhi Zeng Zhi Wan Yu Cao |
| author_facet | Dongze Li Lei Ye Yarong He Xiaoping Cao Jining Liu Wu Zhong Linghong Cao Rui Zeng Zhi Zeng Zhi Wan Yu Cao |
| author_sort | Dongze Li |
| collection | DOAJ |
| description | BackgroundThe long‐term association between the status of the false lumen and poor patient outcomes in acute aortic dissection (AAD) remains unclear. This systematic review and meta‐analysis investigated whether the status of the false lumen was a predictor of poor long‐term survival in AAD. Methods and ResultsEleven cohort studies (2924 participants) exploring the association between the false lumen status and long‐term outcomes (>1 year) in AAD were included. All studies reported multivariate‐adjusted hazard ratios (HRs) with 95% CIs for long‐term outcomes, according to false lumen status. Pooled HRs for mortality and aortic events were computed and weighted using generic inverse‐variance and random‐effect modeling. Residual patent false lumen was an independent predictor of long‐term mortality in AAD type A (HR, 1.71; 95% CI, 1.16–2.52; P=0.007) and type B (HR, 2.79; 95% CI, 1.80–4.32; P<0.001). AAD patients with residual patent false lumen exhibited an increased risk of aortic events (HR, 5.43; 95% CI, 2.95–9.99; P<0.001). Partial false lumen thrombosis was independently associated with long‐term mortality in type B AAD (HR, 2.24; 95% CI, 1.37–3.65; P=0.001). This association was not observed in AAD type A patients (HR, 1.75; 95% CI, 0.88–3.45; P=0.211). ConclusionsThe false lumen status influences late outcomes in AAD. Residual patent false lumen is independently associated with poor long‐term survival in AAD. However, only type B AAD patients with partial false lumen thrombosis had an increased late mortality risk. |
| first_indexed | 2024-12-22T21:46:26Z |
| format | Article |
| id | doaj.art-f142f3b154824afda67d555f63b12726 |
| institution | Directory Open Access Journal |
| issn | 2047-9980 |
| language | English |
| last_indexed | 2024-12-22T21:46:26Z |
| publishDate | 2016-05-01 |
| publisher | Wiley |
| record_format | Article |
| series | Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease |
| spelling | doaj.art-f142f3b154824afda67d555f63b127262022-12-21T18:11:29ZengWileyJournal of the American Heart Association: Cardiovascular and Cerebrovascular Disease2047-99802016-05-015510.1161/JAHA.115.003172False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐AnalysisDongze Li0Lei Ye1Yarong He2Xiaoping Cao3Jining Liu4Wu Zhong5Linghong Cao6Rui Zeng7Zhi Zeng8Zhi Wan9Yu Cao10Department of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, Affiliated Hospital of North Sichuan Medical College, Nanchong, ChinaDepartment of Emergency Medicine, Mianyang Central Hospital, Mianyang, ChinaDepartment of Emergency Medicine, Affiliated Hospital of Luzhou Medical College, Luzhou, ChinaDepartment of Emergency Medicine, Zigong No. 4 People's Hospital, Zigong, ChinaDepartment of Cardiology, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaDepartment of Emergency Medicine, West China Hospital, Sichuan University, Chengdu, ChinaBackgroundThe long‐term association between the status of the false lumen and poor patient outcomes in acute aortic dissection (AAD) remains unclear. This systematic review and meta‐analysis investigated whether the status of the false lumen was a predictor of poor long‐term survival in AAD. Methods and ResultsEleven cohort studies (2924 participants) exploring the association between the false lumen status and long‐term outcomes (>1 year) in AAD were included. All studies reported multivariate‐adjusted hazard ratios (HRs) with 95% CIs for long‐term outcomes, according to false lumen status. Pooled HRs for mortality and aortic events were computed and weighted using generic inverse‐variance and random‐effect modeling. Residual patent false lumen was an independent predictor of long‐term mortality in AAD type A (HR, 1.71; 95% CI, 1.16–2.52; P=0.007) and type B (HR, 2.79; 95% CI, 1.80–4.32; P<0.001). AAD patients with residual patent false lumen exhibited an increased risk of aortic events (HR, 5.43; 95% CI, 2.95–9.99; P<0.001). Partial false lumen thrombosis was independently associated with long‐term mortality in type B AAD (HR, 2.24; 95% CI, 1.37–3.65; P=0.001). This association was not observed in AAD type A patients (HR, 1.75; 95% CI, 0.88–3.45; P=0.211). ConclusionsThe false lumen status influences late outcomes in AAD. Residual patent false lumen is independently associated with poor long‐term survival in AAD. However, only type B AAD patients with partial false lumen thrombosis had an increased late mortality risk.https://www.ahajournals.org/doi/10.1161/JAHA.115.003172aortic dissectionfalse lumenmeta‐analysisthrombosis |
| spellingShingle | Dongze Li Lei Ye Yarong He Xiaoping Cao Jining Liu Wu Zhong Linghong Cao Rui Zeng Zhi Zeng Zhi Wan Yu Cao False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis Journal of the American Heart Association: Cardiovascular and Cerebrovascular Disease aortic dissection false lumen meta‐analysis thrombosis |
| title | False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis |
| title_full | False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis |
| title_fullStr | False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis |
| title_full_unstemmed | False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis |
| title_short | False Lumen Status in Patients With Acute Aortic Dissection: A Systematic Review and Meta‐Analysis |
| title_sort | false lumen status in patients with acute aortic dissection a systematic review and meta analysis |
| topic | aortic dissection false lumen meta‐analysis thrombosis |
| url | https://www.ahajournals.org/doi/10.1161/JAHA.115.003172 |
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