Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems
Fabrizio Spada, Tanya M Barnes, Kerryn A Greive Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.Materials and methods: A new moisturiz...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2018-10-01
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| Series: | Clinical, Cosmetic and Investigational Dermatology |
| Subjects: | |
| Online Access: | https://www.dovepress.com/skin-hydration-is-significantly-increased-by-a-cream-formulated-to-mim-peer-reviewed-article-CCID |
| _version_ | 1818544128244318208 |
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| author | Spada F Barnes TM Greive KA |
| author_facet | Spada F Barnes TM Greive KA |
| author_sort | Spada F |
| collection | DOAJ |
| description | Fabrizio Spada, Tanya M Barnes, Kerryn A Greive Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin’s own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Transepidermal water loss (TEWL) was also measured following a single application of Ceramide cream compared to baseline, and its safety was assessed by repeat insult patch test, ophthalmologist and pediatric testing.Results: A single topical application of either the Ceramide cream or the three reference moisturizers resulted in a significant increase in skin hydration over time (P<0.001). The placebo cream did not significantly increase skin hydration at any time point. At 24 hours post-application, skin hydration measured for Ceramide cream was significantly greater (P<0.05) than that measured for all three of the reference moisturizers tested. Ceramide cream was also found to significantly decrease TEWL (P<0.001) over 24 hours, and was shown to be non-sensitizing to the skin of both adults and children and non-irritating to the skin, eyes and related eye area.Conclusion: Ceramide cream increases skin hydration and improves barrier function which may make it suitable for use on dry skin. Keywords: ceramide, moisturizer, stratum corneum, dry skin, humectant, emollient, occludent, transepidermal water loss, natural moisturizing factor |
| first_indexed | 2024-12-11T22:44:24Z |
| format | Article |
| id | doaj.art-f1449d09f38a467b8a9b71b9c7a5a175 |
| institution | Directory Open Access Journal |
| issn | 1178-7015 |
| language | English |
| last_indexed | 2024-12-11T22:44:24Z |
| publishDate | 2018-10-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | Clinical, Cosmetic and Investigational Dermatology |
| spelling | doaj.art-f1449d09f38a467b8a9b71b9c7a5a1752022-12-22T00:47:40ZengDove Medical PressClinical, Cosmetic and Investigational Dermatology1178-70152018-10-01Volume 1149149741474Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systemsSpada FBarnes TMGreive KAFabrizio Spada, Tanya M Barnes, Kerryn A Greive Research and Development, Ego Pharmaceuticals Pty Ltd, Braeside, VIC, Australia Background: Moisturizers are topical products designed to improve and maintain the skin barrier function and to help prevent dry skin.Materials and methods: A new moisturizer (Ceramide cream) was formulated containing ingredients which mimic the skin’s own natural moisturizing systems. Corneometry was performed at baseline, 2, 4, 6 and 24 hours following a single application of Ceramide cream to healthy skin, and compared to three reference moisturizers available over-the-counter, and placebo. Transepidermal water loss (TEWL) was also measured following a single application of Ceramide cream compared to baseline, and its safety was assessed by repeat insult patch test, ophthalmologist and pediatric testing.Results: A single topical application of either the Ceramide cream or the three reference moisturizers resulted in a significant increase in skin hydration over time (P<0.001). The placebo cream did not significantly increase skin hydration at any time point. At 24 hours post-application, skin hydration measured for Ceramide cream was significantly greater (P<0.05) than that measured for all three of the reference moisturizers tested. Ceramide cream was also found to significantly decrease TEWL (P<0.001) over 24 hours, and was shown to be non-sensitizing to the skin of both adults and children and non-irritating to the skin, eyes and related eye area.Conclusion: Ceramide cream increases skin hydration and improves barrier function which may make it suitable for use on dry skin. Keywords: ceramide, moisturizer, stratum corneum, dry skin, humectant, emollient, occludent, transepidermal water loss, natural moisturizing factorhttps://www.dovepress.com/skin-hydration-is-significantly-increased-by-a-cream-formulated-to-mim-peer-reviewed-article-CCIDceramidemoisturizerstratum corneumhydrationtransepidermal water lossnatural moisturizing factor |
| spellingShingle | Spada F Barnes TM Greive KA Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems Clinical, Cosmetic and Investigational Dermatology ceramide moisturizer stratum corneum hydration transepidermal water loss natural moisturizing factor |
| title | Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems |
| title_full | Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems |
| title_fullStr | Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems |
| title_full_unstemmed | Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems |
| title_short | Skin hydration is significantly increased by a cream formulated to mimic the skin’s own natural moisturizing systems |
| title_sort | skin hydration is significantly increased by a cream formulated to mimic the skin rsquo s own natural moisturizing systems |
| topic | ceramide moisturizer stratum corneum hydration transepidermal water loss natural moisturizing factor |
| url | https://www.dovepress.com/skin-hydration-is-significantly-increased-by-a-cream-formulated-to-mim-peer-reviewed-article-CCID |
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