Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits
In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-cla...
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| Format: | Article |
| Language: | English |
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Bangladesh Pharmacological Society
2013-05-01
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| Series: | Bangladesh Journal of Pharmacology |
| Subjects: | |
| Online Access: | https://www.banglajol.info/index.php/BJP/article/view/14519 |
| _version_ | 1818822999121330176 |
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| author | . Alamgeer Muhammad Rashid Sajid Bashir Muhammad Naveed Mushtaq Hafeez Ullah Khan Muhammad Nasir Hayat Malik Abdul Qayyum Muhammad Shafeeq ur Rahaman |
| author_facet | . Alamgeer Muhammad Rashid Sajid Bashir Muhammad Naveed Mushtaq Hafeez Ullah Khan Muhammad Nasir Hayat Malik Abdul Qayyum Muhammad Shafeeq ur Rahaman |
| author_sort | . Alamgeer |
| collection | DOAJ |
| description | In the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-clamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications. |
| first_indexed | 2024-12-18T23:33:00Z |
| format | Article |
| id | doaj.art-f145517eb3f345a2b4277222fd59efa7 |
| institution | Directory Open Access Journal |
| issn | 1991-0088 |
| language | English |
| last_indexed | 2024-12-18T23:33:00Z |
| publishDate | 2013-05-01 |
| publisher | Bangladesh Pharmacological Society |
| record_format | Article |
| series | Bangladesh Journal of Pharmacology |
| spelling | doaj.art-f145517eb3f345a2b4277222fd59efa72022-12-21T20:47:38ZengBangladesh Pharmacological SocietyBangladesh Journal of Pharmacology1991-00882013-05-018210.3329/bjp.v8i2.14519Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits. Alamgeer0Muhammad Rashid1Sajid Bashir2Muhammad Naveed Mushtaq3Hafeez Ullah Khan4Muhammad Nasir Hayat MalikAbdul QayyumMuhammad Shafeeq ur RahamanFaculty of Pharmacy, University of Sargodha, SargodhaSchool of Pharmacy, The University of Faisalabad, FaisalabadFaculty of Pharmacy, University of Sargodha, SargodhaFaculty of Pharmacy, University of Sargodha, SargodhaFaculty of Pharmacy, University of Sargodha, SargodhaIn the present study crude powder and various extracts of Teucrium stocksianum were evaluated for antidiabetic effect in alloxan-induced diabetic rabbits. Crude extract significantly reduced blood glucose level of normal and diabetic rabbits. The results were comparable with standard drug gliben-clamide. Ethyl acetate extract (500 mg/kg) produced maximum decrease in blood glucose level among all the extracts and was selected for further study. Ethyl acetate extract significantly inhibited rise in glucose level in normal rabbits after an oral glucose load. The extract showed synergistic effect with different doses of insulin. Serum insulin level of diabetic rabbits was also significantly increased by the extract. HbA1c level was significantly (p<0.05) reduced whereas hemoglobin level was significantly increased by the extract. It is concluded that ethyl acetate extract may be a good remedy to manage diabetes and its complications.https://www.banglajol.info/index.php/BJP/article/view/14519Blood glucose levelethyl acetate extractHbA1cinsulinTeucrium stocksianum Boiss |
| spellingShingle | . Alamgeer Muhammad Rashid Sajid Bashir Muhammad Naveed Mushtaq Hafeez Ullah Khan Muhammad Nasir Hayat Malik Abdul Qayyum Muhammad Shafeeq ur Rahaman Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits Bangladesh Journal of Pharmacology Blood glucose level ethyl acetate extract HbA1c insulin Teucrium stocksianum Boiss |
| title | Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits |
| title_full | Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits |
| title_fullStr | Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits |
| title_full_unstemmed | Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits |
| title_short | Comparative hypoglycemic activity of different extracts of Teucrium stocksianum in diabetic rabbits |
| title_sort | comparative hypoglycemic activity of different extracts of teucrium stocksianum in diabetic rabbits |
| topic | Blood glucose level ethyl acetate extract HbA1c insulin Teucrium stocksianum Boiss |
| url | https://www.banglajol.info/index.php/BJP/article/view/14519 |
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