Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients

Systems Biology Reveals Relevant Gaps in Fc-γR Expression, Impaired Regulatory Cytokine Microenvironment Interfaced With Anti-Trypanosoma cruzi IgG Reactivity in Cardiac Chagas Disease Patients

The systems biology approach has become an innovative tool when it comes to shedding light on the complex immune response underlying the development/maintenance of distinct clinical forms of Chagas disease. The goal of this study was to describe an integrative overview of Fc-γR expression, cytokine...

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Bibliographic Details
Main Authors: Juliana de A. S. Gomes, Fernanda F. de Araújo, Daniele M. Vitelli-Avelar, Renato Sathler-Avelar, Paula S. Lage, Ana P. B. Wendling, Isabela N. P. C. do Vale, João C. P. Dias, Silvana M. Elói-Santos, Andréa Teixeira-Carvalho, Olindo A. Martins-Filho
Format: Article
Language:English
Published: Frontiers Media S.A. 2018-07-01
Series:Frontiers in Microbiology
Subjects:
Chagas disease
Fc receptors
Trypanosoma cruzi
cytokines
immune response
Online Access:https://www.frontiersin.org/article/10.3389/fmicb.2018.01608/full

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