Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study
Both obstructive sleep apnea (OSA) and inflammation have now been recognized as imposing substantial cardiometabolic risk. However, no prospective study has reported whether the coexistence of OSA and inflammation exacerbates the progressive arterial stiffening. Thus, the purpose of this study is to...
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| Format: | Article |
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MDPI AG
2022-11-01
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| Series: | Life |
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| Online Access: | https://www.mdpi.com/2075-1729/12/11/1823 |
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| author | Jinkwan Kim Dae Wui Yoon Sungmin Myoung Seung Ku Lee Chol Shin |
| author_facet | Jinkwan Kim Dae Wui Yoon Sungmin Myoung Seung Ku Lee Chol Shin |
| author_sort | Jinkwan Kim |
| collection | DOAJ |
| description | Both obstructive sleep apnea (OSA) and inflammation have now been recognized as imposing substantial cardiometabolic risk. However, no prospective study has reported whether the coexistence of OSA and inflammation exacerbates the progressive arterial stiffening. Thus, the purpose of this study is to examine whether these conditions increase the risk of the progression of arterial stiffening. A total of 1945 participants were randomly selected for the study. Subjects with elevated inflammation were divided by high-sensitivity C-reactive protein (hsCRP) levels. A polysomnography and brachial–ankle pulse wave velocity (baPWV) were performed. The elevation of the baPWV was defined as the levels in the highest quartile of the baPWV. The percentage of the elevated baPWV and the change in the baPWV (ΔbaPWV) were higher in individuals with OSA and higher hsCRP levels. After adjusting for confounders, the participants with OSA and inflammation in the groups not treated with antihypertensive medication had a higher risk of an elevated ΔbaPWV in contrast to those with neither variable. Particularly, the alteration in the baPWV differed significantly based on the existence of moderate-to-severe OSA and inflammation at the 6-year follow-up. In combination, these conditions are associated with an accelerated risk of a future burden of the progression of the arterial stiffness, suggesting a potential important role in the increased risk of CVD. |
| first_indexed | 2024-03-09T18:55:17Z |
| format | Article |
| id | doaj.art-f145b38c99504d968a3052368b731316 |
| institution | Directory Open Access Journal |
| issn | 2075-1729 |
| language | English |
| last_indexed | 2024-03-09T18:55:17Z |
| publishDate | 2022-11-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Life |
| spelling | doaj.art-f145b38c99504d968a3052368b7313162023-11-24T05:31:31ZengMDPI AGLife2075-17292022-11-011211182310.3390/life12111823Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year StudyJinkwan Kim0Dae Wui Yoon1Sungmin Myoung2Seung Ku Lee3Chol Shin4Department of Biomedical Laboratory Science, College of Health Science, Jungwon University, Geo-San 28024, KoreaDepartment of Biomedical Laboratory Science, College of Health Science, Jungwon University, Geo-San 28024, KoreaDepartment of Medical Information and Administration, College of Health Science, Jungwon University, Geo-San 28024, KoreaInstitute of Human Genomic Study, Korea University Ansan Hospital, Korea University, Ansan 15355, KoreaInstitute of Human Genomic Study, Korea University Ansan Hospital, Korea University, Ansan 15355, KoreaBoth obstructive sleep apnea (OSA) and inflammation have now been recognized as imposing substantial cardiometabolic risk. However, no prospective study has reported whether the coexistence of OSA and inflammation exacerbates the progressive arterial stiffening. Thus, the purpose of this study is to examine whether these conditions increase the risk of the progression of arterial stiffening. A total of 1945 participants were randomly selected for the study. Subjects with elevated inflammation were divided by high-sensitivity C-reactive protein (hsCRP) levels. A polysomnography and brachial–ankle pulse wave velocity (baPWV) were performed. The elevation of the baPWV was defined as the levels in the highest quartile of the baPWV. The percentage of the elevated baPWV and the change in the baPWV (ΔbaPWV) were higher in individuals with OSA and higher hsCRP levels. After adjusting for confounders, the participants with OSA and inflammation in the groups not treated with antihypertensive medication had a higher risk of an elevated ΔbaPWV in contrast to those with neither variable. Particularly, the alteration in the baPWV differed significantly based on the existence of moderate-to-severe OSA and inflammation at the 6-year follow-up. In combination, these conditions are associated with an accelerated risk of a future burden of the progression of the arterial stiffness, suggesting a potential important role in the increased risk of CVD.https://www.mdpi.com/2075-1729/12/11/1823obstructive sleep apneainflammationhigh sensitivity C-reactive proteinarterial stiffnesspulse wave velocitycardiovascular disease |
| spellingShingle | Jinkwan Kim Dae Wui Yoon Sungmin Myoung Seung Ku Lee Chol Shin Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study Life obstructive sleep apnea inflammation high sensitivity C-reactive protein arterial stiffness pulse wave velocity cardiovascular disease |
| title | Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study |
| title_full | Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study |
| title_fullStr | Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study |
| title_full_unstemmed | Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study |
| title_short | Coexistence of Moderate-to-Severe Obstructive Sleep Apnea and Inflammation Accelerates the Risk of Progression of Arterial Stiffness: A Prospective 6-Year Study |
| title_sort | coexistence of moderate to severe obstructive sleep apnea and inflammation accelerates the risk of progression of arterial stiffness a prospective 6 year study |
| topic | obstructive sleep apnea inflammation high sensitivity C-reactive protein arterial stiffness pulse wave velocity cardiovascular disease |
| url | https://www.mdpi.com/2075-1729/12/11/1823 |
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