Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Cell culture-based profiling across mammals reveals DNA repair and metabolism as determinants of species longevity

Mammalian lifespan differs by >100 fold, but the mechanisms associated with such longevity differences are not understood. Here, we conducted a study on primary skin fibroblasts isolated from 16 species of mammals and maintained under identical cell culture conditions. We developed a pipeline...

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Bibliographic Details
Main Authors: Siming Ma, Akhil Upneja, Andrzej Galecki, Yi-Miau Tsai, Charles F Burant, Sasha Raskind, Quanwei Zhang, Zhengdong D Zhang, Andrei Seluanov, Vera Gorbunova, Clary B Clish, Richard A Miller, Vadim N Gladyshev
Format: Article
Language:English
Published: eLife Sciences Publications Ltd 2016-11-01
Series:eLife
Subjects:
lifespan
aging
gene expression
metabolite profiling
Online Access:https://elifesciences.org/articles/19130

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