β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

β-Sitosterol and Gemcitabine Exhibit Synergistic Anti-pancreatic Cancer Activity by Modulating Apoptosis and Inhibiting Epithelial–Mesenchymal Transition by Deactivating Akt/GSK-3β Signaling

β-sitosterol (BS), a major bioactive constituent present in plants, has shown potent anti-cancer activity against many human cancer cells, but its activity in pancreatic cancer (PC) cells has rarely been reported. Gemcitabine (GEM) is one of the first-line drugs for PC therapy, however, the treatmen...

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Bibliographic Details
Main Authors: Zhang-qi Cao, Xue-xi Wang, Li Lu, Jing-wen Xu, Xiao-bin Li, Guang-ru Zhang, Zhan-jun Ma, An-chen Shi, Yan Wang, Yu-jun Song
Format: Article
Language:English
Published: Frontiers Media S.A. 2019-01-01
Series:Frontiers in Pharmacology
Subjects:
β-sitosterol
gemcitabine
pancreatic cancer
apoptosis
EMT
AKT
Online Access:https://www.frontiersin.org/article/10.3389/fphar.2018.01525/full

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