Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China
ABSTRACTThis study aims to summarize the clinical characteristics and prognosis of Listeria monocytogenes (LM) meningitis in children in Chongqing, China. A retrospective analysis of the clinical data and follow-up results of 20 LM meningitis patients admitted to the Children’s Hospital of Chongqing...
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| Format: | Article |
| Language: | English |
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American Society for Microbiology
2024-03-01
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| Series: | Microbiology Spectrum |
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| Online Access: | https://journals.asm.org/doi/10.1128/spectrum.03244-23 |
| _version_ | 1797276780434817024 |
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| author | Xueqian Xia Lingyu Zhang Hao Zheng Xiaoling Peng Li Jiang Yue Hu |
| author_facet | Xueqian Xia Lingyu Zhang Hao Zheng Xiaoling Peng Li Jiang Yue Hu |
| author_sort | Xueqian Xia |
| collection | DOAJ |
| description | ABSTRACTThis study aims to summarize the clinical characteristics and prognosis of Listeria monocytogenes (LM) meningitis in children in Chongqing, China. A retrospective analysis of the clinical data and follow-up results of 20 LM meningitis patients admitted to the Children’s Hospital of Chongqing Medical University (CHCMU) from January 2012 to December 2022 was performed. The LM meningitis incidence rate was between 0 and 14.3 per 100,000 persons. The median age at onset was 8.98 months. There were five neonate cases, which all had perinatal abnormalities. Seven non-neonatal cases (7/15, 46.7%) had a documented history of contaminated food intake. One case had primary immunodeficiency. The most common symptoms were fever (20/20), altered consciousness (19/20), and vomiting (15/20). Seven cases had seizures, eight cases had cranial nerve involvement, eight cases had positive Babinski sign, and 10 cases had positive meningeal signs. The most common complications were hyponatremia (6/20), hypokalemia (6/20), respiratory failure (5/20), subdural effusion (3/20), and hydrocephalus (2/20). Treatment primarily involved monotherapy or combination therapy with meropenem (15/20) and ampicillin (10/20). Fifteen cases were treated with monotherapy or combination therapy using vancomycin. Twelve cases were successfully followed up from 10 months to 9 years and 6 months, and all had favorable long-term outcomes. LM meningitis incidence in children is low and with nonspecific clinical manifestations. Strengthening food hygiene and safety education, and avoiding infections during pregnancy are important to prevent LM infection in neonates and high-risk individuals. Meropenem and ampicillin are the preferred treatments. Early diagnosis and treatment can improve prognosis.IMPORTANCEThe incidence of LM meningitis is extremely low, and there is currently no standardized treatment. We conducted a retrospective analysis of ten years of data from CHCMU regarding diagnosed LM meningitis cases, aiming to provide clinical evidence for the diagnosis and treatment. |
| first_indexed | 2024-03-07T15:33:12Z |
| format | Article |
| id | doaj.art-f1465d821ea744a1917d4e03f98a84d8 |
| institution | Directory Open Access Journal |
| issn | 2165-0497 |
| language | English |
| last_indexed | 2024-03-07T15:33:12Z |
| publishDate | 2024-03-01 |
| publisher | American Society for Microbiology |
| record_format | Article |
| series | Microbiology Spectrum |
| spelling | doaj.art-f1465d821ea744a1917d4e03f98a84d82024-03-05T14:04:36ZengAmerican Society for MicrobiologyMicrobiology Spectrum2165-04972024-03-0112310.1128/spectrum.03244-23Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in ChinaXueqian Xia0Lingyu Zhang1Hao Zheng2Xiaoling Peng3Li Jiang4Yue Hu5Department of Neurology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neonatology, Women’s Hospital, School of Medicine, Zhejiang University, Hangzhou, ChinaDepartment of Neurology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaGuangdong Provincial Key Laboratory of Interdisciplinary Research and Application for Data Science, BNU-HKBU United International College, Zhuha, ChinaDepartment of Neurology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaDepartment of Neurology, Children’s Hospital of Chongqing Medical University, Chongqing, ChinaABSTRACTThis study aims to summarize the clinical characteristics and prognosis of Listeria monocytogenes (LM) meningitis in children in Chongqing, China. A retrospective analysis of the clinical data and follow-up results of 20 LM meningitis patients admitted to the Children’s Hospital of Chongqing Medical University (CHCMU) from January 2012 to December 2022 was performed. The LM meningitis incidence rate was between 0 and 14.3 per 100,000 persons. The median age at onset was 8.98 months. There were five neonate cases, which all had perinatal abnormalities. Seven non-neonatal cases (7/15, 46.7%) had a documented history of contaminated food intake. One case had primary immunodeficiency. The most common symptoms were fever (20/20), altered consciousness (19/20), and vomiting (15/20). Seven cases had seizures, eight cases had cranial nerve involvement, eight cases had positive Babinski sign, and 10 cases had positive meningeal signs. The most common complications were hyponatremia (6/20), hypokalemia (6/20), respiratory failure (5/20), subdural effusion (3/20), and hydrocephalus (2/20). Treatment primarily involved monotherapy or combination therapy with meropenem (15/20) and ampicillin (10/20). Fifteen cases were treated with monotherapy or combination therapy using vancomycin. Twelve cases were successfully followed up from 10 months to 9 years and 6 months, and all had favorable long-term outcomes. LM meningitis incidence in children is low and with nonspecific clinical manifestations. Strengthening food hygiene and safety education, and avoiding infections during pregnancy are important to prevent LM infection in neonates and high-risk individuals. Meropenem and ampicillin are the preferred treatments. Early diagnosis and treatment can improve prognosis.IMPORTANCEThe incidence of LM meningitis is extremely low, and there is currently no standardized treatment. We conducted a retrospective analysis of ten years of data from CHCMU regarding diagnosed LM meningitis cases, aiming to provide clinical evidence for the diagnosis and treatment.https://journals.asm.org/doi/10.1128/spectrum.03244-23Listeria monocytogenes meningitischildrenclinical characteristicstreatment |
| spellingShingle | Xueqian Xia Lingyu Zhang Hao Zheng Xiaoling Peng Li Jiang Yue Hu Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China Microbiology Spectrum Listeria monocytogenes meningitis children clinical characteristics treatment |
| title | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China |
| title_full | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China |
| title_fullStr | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China |
| title_full_unstemmed | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China |
| title_short | Clinical characteristics and prognosis of pediatric Listeria monocytogenes meningitis based on 10-year data from a large children’s hospital in China |
| title_sort | clinical characteristics and prognosis of pediatric listeria monocytogenes meningitis based on 10 year data from a large children s hospital in china |
| topic | Listeria monocytogenes meningitis children clinical characteristics treatment |
| url | https://journals.asm.org/doi/10.1128/spectrum.03244-23 |
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