Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?
As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overv...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2023-01-01
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| Series: | International Journal of Molecular Sciences |
| Subjects: | |
| Online Access: | https://www.mdpi.com/1422-0067/24/3/2218 |
| _version_ | 1797624441437421568 |
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| author | Matteo Puccetti Aurelie Schoubben Stefano Giovagnoli Maurizio Ricci |
| author_facet | Matteo Puccetti Aurelie Schoubben Stefano Giovagnoli Maurizio Ricci |
| author_sort | Matteo Puccetti |
| collection | DOAJ |
| description | As an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overview of current mRNA therapeutic applications and discuss key biological barriers to delivery and recent advances in the development of nonviral systems. The relevant challenges that LNPs face in achieving cost-effective and widespread clinical implementation when delivering mRNA are likewise discussed. |
| first_indexed | 2024-03-11T09:42:23Z |
| format | Article |
| id | doaj.art-f1467b1fe0494152b4ed9df0830ca0d4 |
| institution | Directory Open Access Journal |
| issn | 1661-6596 1422-0067 |
| language | English |
| last_indexed | 2024-03-11T09:42:23Z |
| publishDate | 2023-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | International Journal of Molecular Sciences |
| spelling | doaj.art-f1467b1fe0494152b4ed9df0830ca0d42023-11-16T16:54:02ZengMDPI AGInternational Journal of Molecular Sciences1661-65961422-00672023-01-01243221810.3390/ijms24032218Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age?Matteo Puccetti0Aurelie Schoubben1Stefano Giovagnoli2Maurizio Ricci3Department of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyDepartment of Pharmaceutical Sciences, University of Perugia, 06123 Perugia, ItalyAs an appealing alternative to treat and prevent diseases ranging from cancer to COVID-19, mRNA has demonstrated significant clinical effects. Nanotechnology facilitates the successful implementation of the systemic delivery of mRNA for safe human consumption. In this manuscript, we provide an overview of current mRNA therapeutic applications and discuss key biological barriers to delivery and recent advances in the development of nonviral systems. The relevant challenges that LNPs face in achieving cost-effective and widespread clinical implementation when delivering mRNA are likewise discussed.https://www.mdpi.com/1422-0067/24/3/2218RNA lipid nanoparticlesRNA delivery systemsbiodrug nanotechnology |
| spellingShingle | Matteo Puccetti Aurelie Schoubben Stefano Giovagnoli Maurizio Ricci Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? International Journal of Molecular Sciences RNA lipid nanoparticles RNA delivery systems biodrug nanotechnology |
| title | Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? |
| title_full | Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? |
| title_fullStr | Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? |
| title_full_unstemmed | Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? |
| title_short | Biodrug Delivery Systems: Do mRNA Lipid Nanoparticles Come of Age? |
| title_sort | biodrug delivery systems do mrna lipid nanoparticles come of age |
| topic | RNA lipid nanoparticles RNA delivery systems biodrug nanotechnology |
| url | https://www.mdpi.com/1422-0067/24/3/2218 |
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