PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus
The PACAP-PAC1R neuropeptide system regulates neuroendocrine stress responses. Here the authors demonstrate a role for PACAP-PAC1R in ventromedial hypothalamus in modulating fear extinction.
| Main Authors: | , , , , , , , , , , , , , , , , |
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| Format: | Article |
| Language: | English |
| Published: |
Nature Portfolio
2022-07-01
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| Series: | Nature Communications |
| Online Access: | https://doi.org/10.1038/s41467-022-31442-w |
| _version_ | 1811223085096894464 |
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| author | E. R. Velasco A. Florido Á Flores E. Senabre A. Gomez-Gomez A. Torres A. Roca S. Norrholm E. L. Newman P. Das R. A. Ross A. Lori O. J. Pozo K. J. Ressler L. L. Garcia-Esteve T. Jovanovic R. Andero |
| author_facet | E. R. Velasco A. Florido Á Flores E. Senabre A. Gomez-Gomez A. Torres A. Roca S. Norrholm E. L. Newman P. Das R. A. Ross A. Lori O. J. Pozo K. J. Ressler L. L. Garcia-Esteve T. Jovanovic R. Andero |
| author_sort | E. R. Velasco |
| collection | DOAJ |
| description | The PACAP-PAC1R neuropeptide system regulates neuroendocrine stress responses. Here the authors demonstrate a role for PACAP-PAC1R in ventromedial hypothalamus in modulating fear extinction. |
| first_indexed | 2024-04-12T08:25:58Z |
| format | Article |
| id | doaj.art-f146a9407c914b2aaff3189cc34233b8 |
| institution | Directory Open Access Journal |
| issn | 2041-1723 |
| language | English |
| last_indexed | 2024-04-12T08:25:58Z |
| publishDate | 2022-07-01 |
| publisher | Nature Portfolio |
| record_format | Article |
| series | Nature Communications |
| spelling | doaj.art-f146a9407c914b2aaff3189cc34233b82022-12-22T03:40:23ZengNature PortfolioNature Communications2041-17232022-07-0113111710.1038/s41467-022-31442-wPACAP-PAC1R modulates fear extinction via the ventromedial hypothalamusE. R. Velasco0A. Florido1Á Flores2E. Senabre3A. Gomez-Gomez4A. Torres5A. Roca6S. Norrholm7E. L. Newman8P. Das9R. A. Ross10A. Lori11O. J. Pozo12K. J. Ressler13L. L. Garcia-Esteve14T. Jovanovic15R. Andero16Institut de Neurociències, Universitat Autònoma de BarcelonaInstitut de Neurociències, Universitat Autònoma de BarcelonaInstitut de Neurociències, Universitat Autònoma de BarcelonaLaboratory of Neuropharmacology-NeuroPhar, Department of Experimental and Health Sciences, University Pompeu FabraIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute)Perinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPSPerinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPSDepartment of Psychiatry and Behavioral Neuroscience, Wayne State UniversityMcLean Hospital, Department of Psychiatry, Harvard Medical SchoolDepartment of Neuroscience, Albert Einstein College of Medicine, Psychiatry Research Institute of Montefiore and EinsteinDepartment of Neuroscience, Albert Einstein College of Medicine, Psychiatry Research Institute of Montefiore and EinsteinDepartment of Psychiatry & Behavioral Sciences, Emory UniversityIntegrative Pharmacology and Systems Neuroscience Research Group, Neurosciences Research Program, IMIM (Hospital del Mar Medical Research Institute)McLean Hospital, Department of Psychiatry, Harvard Medical SchoolPerinatal Mental health Unit, Department of Psychiatry and Clinical Psychology, Institute of Neuroscience, Hospital Clínic, IDIBAPSDepartment of Psychiatry and Behavioral Neuroscience, Wayne State UniversityDepartament de Psicobiologia i de Metodologia de les Ciències de la Salut, Universitat Autònoma de BarcelonaThe PACAP-PAC1R neuropeptide system regulates neuroendocrine stress responses. Here the authors demonstrate a role for PACAP-PAC1R in ventromedial hypothalamus in modulating fear extinction.https://doi.org/10.1038/s41467-022-31442-w |
| spellingShingle | E. R. Velasco A. Florido Á Flores E. Senabre A. Gomez-Gomez A. Torres A. Roca S. Norrholm E. L. Newman P. Das R. A. Ross A. Lori O. J. Pozo K. J. Ressler L. L. Garcia-Esteve T. Jovanovic R. Andero PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus Nature Communications |
| title | PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus |
| title_full | PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus |
| title_fullStr | PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus |
| title_full_unstemmed | PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus |
| title_short | PACAP-PAC1R modulates fear extinction via the ventromedial hypothalamus |
| title_sort | pacap pac1r modulates fear extinction via the ventromedial hypothalamus |
| url | https://doi.org/10.1038/s41467-022-31442-w |
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