Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC

Inhibiting ALK-TOPK signaling pathway promotes cell apoptosis of ALK-positive NSCLC

Abstract T-LAK cell-oriented protein kinase (TOPK) is a potential therapeutic target in tumors. However, its role in anaplastic lymphoma kinase (ALK)-positive non-small cell lung cancer (NSCLC) has not been reported. Here, we found that TOPK was highly expressed in ALK-positive NSCLC. Additionally,...

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Bibliographic Details
Main Authors: Juanjuan Xiao, Lu Zhang, Huijun Yi, Ling Zou, Jianmei Mo, Feng Xue, Jinhua Zheng, Yingze Huang, Hui Lu, Hansheng Wu, Peipei Xue, Xin Zhang, Lifei He, Zhaoxin Li, Shigui Pang, Guibin Qiao, Qiuhong Duan, Feng Zhu
Format: Article
Language:English
Published: Nature Publishing Group 2022-09-01
Series:Cell Death and Disease
Online Access:https://doi.org/10.1038/s41419-022-05260-3

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