Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes
Abstract Background Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes (T2D). Methods This pros...
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| Format: | Article |
| Language: | English |
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BMC
2024-02-01
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| Series: | Cardiovascular Diabetology |
| Subjects: | |
| Online Access: | https://doi.org/10.1186/s12933-024-02156-8 |
| _version_ | 1797276025641500672 |
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| author | Resham L. Gurung Sylvia Liu Jian-Jun Liu Yiamunaa M. Huili Zheng Clara Chan Keven Ang Tavintharan Subramaniam Chee Fang Sum Su Chi Lim |
| author_facet | Resham L. Gurung Sylvia Liu Jian-Jun Liu Yiamunaa M. Huili Zheng Clara Chan Keven Ang Tavintharan Subramaniam Chee Fang Sum Su Chi Lim |
| author_sort | Resham L. Gurung |
| collection | DOAJ |
| description | Abstract Background Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes (T2D). Methods This prospective study included 1083 T2D individuals recruited from a secondary hospital and a primary care facility. The primary outcome was a composite of four-point MACE (nonfatal myocardial infarction, stroke, unstable angina pectoris leading to hospitalization and cardiovascular death). Circulating angiogenin was measured by a proximity extension assay. Cox regression models were used to evaluate the association of baseline plasma angiogenin with the risk of MACE. Results During a median follow-up of 9.3 years, 109 (10%) MACE were identified. Plasma angiogenin was significantly higher in participants with MACE than in those without MACE (P < 0.001). Doubling of plasma angiogenin concentration was associated with a 3.10-fold (95% CI 1.84–5.22) increased risk for MACE. The association was only moderately attenuated after adjustment for demographic and cardiometabolic risk factors (adjusted HR 2.38, 95% CI 1.34–4.23) and remained statistically significant after additional adjustment for estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (uACR) (adjusted HR 1.90, 95% CI 1.02–3.53). A consistent outcome was obtained when plasma angiogenin was analysed as a categorical variable in tertiles. Conclusions Plasma angiogenin was associated with the risk of future cardiovascular events in patients with T2D and may be a promising novel biomarker for identifying high-risk T2D patients for early management. |
| first_indexed | 2024-03-07T15:22:24Z |
| format | Article |
| id | doaj.art-f14ad0d8b43d4736a0c9f323541c5ecd |
| institution | Directory Open Access Journal |
| issn | 1475-2840 |
| language | English |
| last_indexed | 2024-03-07T15:22:24Z |
| publishDate | 2024-02-01 |
| publisher | BMC |
| record_format | Article |
| series | Cardiovascular Diabetology |
| spelling | doaj.art-f14ad0d8b43d4736a0c9f323541c5ecd2024-03-05T17:36:19ZengBMCCardiovascular Diabetology1475-28402024-02-012311810.1186/s12933-024-02156-8Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetesResham L. Gurung0Sylvia Liu1Jian-Jun Liu2Yiamunaa M.3Huili Zheng4Clara Chan5Keven Ang6Tavintharan Subramaniam7Chee Fang Sum8Su Chi Lim9Clinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalClinical Research Unit, Khoo Teck Puat HospitalDiabetes Centre, Admiralty Medical CentreDiabetes Centre, Admiralty Medical CentreClinical Research Unit, Khoo Teck Puat HospitalAbstract Background Angiogenin, an enzyme belonging to the ribonucleases A superfamily, plays an important role in vascular biology. Here, we sought to study the association of plasma angiogenin and major adverse cardiovascular events (MACEs) in patients with type 2 diabetes (T2D). Methods This prospective study included 1083 T2D individuals recruited from a secondary hospital and a primary care facility. The primary outcome was a composite of four-point MACE (nonfatal myocardial infarction, stroke, unstable angina pectoris leading to hospitalization and cardiovascular death). Circulating angiogenin was measured by a proximity extension assay. Cox regression models were used to evaluate the association of baseline plasma angiogenin with the risk of MACE. Results During a median follow-up of 9.3 years, 109 (10%) MACE were identified. Plasma angiogenin was significantly higher in participants with MACE than in those without MACE (P < 0.001). Doubling of plasma angiogenin concentration was associated with a 3.10-fold (95% CI 1.84–5.22) increased risk for MACE. The association was only moderately attenuated after adjustment for demographic and cardiometabolic risk factors (adjusted HR 2.38, 95% CI 1.34–4.23) and remained statistically significant after additional adjustment for estimated glomerular filtration rate (eGFR) and urinary albumin to creatinine ratio (uACR) (adjusted HR 1.90, 95% CI 1.02–3.53). A consistent outcome was obtained when plasma angiogenin was analysed as a categorical variable in tertiles. Conclusions Plasma angiogenin was associated with the risk of future cardiovascular events in patients with T2D and may be a promising novel biomarker for identifying high-risk T2D patients for early management.https://doi.org/10.1186/s12933-024-02156-8AngiogeninMajor adverse cardiovascular eventsType 2 diabetes |
| spellingShingle | Resham L. Gurung Sylvia Liu Jian-Jun Liu Yiamunaa M. Huili Zheng Clara Chan Keven Ang Tavintharan Subramaniam Chee Fang Sum Su Chi Lim Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes Cardiovascular Diabetology Angiogenin Major adverse cardiovascular events Type 2 diabetes |
| title | Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| title_full | Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| title_fullStr | Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| title_full_unstemmed | Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| title_short | Association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| title_sort | association of plasma angiogenin with risk of major cardiovascular events in type 2 diabetes |
| topic | Angiogenin Major adverse cardiovascular events Type 2 diabetes |
| url | https://doi.org/10.1186/s12933-024-02156-8 |
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