Association between soluble α-klotho and mortality risk in middle-aged and older adults
IntroductionStudies on association of α-klotho levels with mortality risk in general population are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort study to investigate the relationship between soluble α-klotho and all-cause mortality in a nationally representat...
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| Format: | Article |
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Frontiers Media S.A.
2023-08-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1246590/full |
| _version_ | 1797737456005545984 |
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| author | Min-Hsiang Chuang Hung-Wei Wang Yun-Ting Huang Ming-Yan Jiang Ming-Yan Jiang |
| author_facet | Min-Hsiang Chuang Hung-Wei Wang Yun-Ting Huang Ming-Yan Jiang Ming-Yan Jiang |
| author_sort | Min-Hsiang Chuang |
| collection | DOAJ |
| description | IntroductionStudies on association of α-klotho levels with mortality risk in general population are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort study to investigate the relationship between soluble α-klotho and all-cause mortality in a nationally representative sample of middle-aged and older adults in the United States (U.S.).MethodsThe study population was 2007-2016 National Health and Nutrition Examination Survey (NHANES) participants, totaling 13,583 adults aged 40-79 years. Participants were divided into 7 groups by septile of α-klotho levels. We linked the NHANES data to the National Death Index to determine participants’ survival status. End of follow-up was participants’ death date or December 31, 2019.ResultsWe observed that males, current smokers, older age, higher body mass index, and lower estimated glomerular filtration rate correlated to lower α-klotho levels, while hepatitis C virus infection correlated to higher α-klotho. The population mortality rate was 11.8 per 10,000 person-months (1,490 deaths); group 1 (the first septile) had higher mortality risk compared with group 2 through group 7. By weighted Cox regression with adjustment for potential confounders, we found that group 2 through group 6, but not group 7, were associated with 25% to 35% lower risk of all-cause mortality compared with group 1. When compared with group 4, we observed that both group 1 (HR: 1.46, 95% CI 1.13-1.88) and group 7 (HR: 1.38, 95% CI 1.09-1.74) were associated with higher mortality risk.ConclusionIn summary, among middle-aged and older U.S. adults, we observed a non-linear association between soluble α-klotho and all-cause mortality, with individuals at the two extremes at increased risk of death. |
| first_indexed | 2024-03-12T13:28:59Z |
| format | Article |
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| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-03-12T13:28:59Z |
| publishDate | 2023-08-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Endocrinology |
| spelling | doaj.art-f14ca77c096b4474b1c668c6611069af2023-08-24T23:09:47ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-08-011410.3389/fendo.2023.12465901246590Association between soluble α-klotho and mortality risk in middle-aged and older adultsMin-Hsiang Chuang0Hung-Wei Wang1Yun-Ting Huang2Ming-Yan Jiang3Ming-Yan Jiang4Renal Division, Department of Internal Medicine, Chi Mei Medical Center, Tainan, TaiwanRenal Division, Department of Internal Medicine, Chi Mei Hospital Chiali, Tainan, TaiwanRenal Division, Department of Internal Medicine, Chi Mei Hospital Chiali, Tainan, TaiwanRenal Division, Department of Internal Medicine, Chi Mei Medical Center, Tainan, TaiwanDepartment of Pharmacy, Chia Nan University of Pharmacy & Science, Tainan, TaiwanIntroductionStudies on association of α-klotho levels with mortality risk in general population are relatively scarce and inconclusive. Therefore, we conducted a population-based cohort study to investigate the relationship between soluble α-klotho and all-cause mortality in a nationally representative sample of middle-aged and older adults in the United States (U.S.).MethodsThe study population was 2007-2016 National Health and Nutrition Examination Survey (NHANES) participants, totaling 13,583 adults aged 40-79 years. Participants were divided into 7 groups by septile of α-klotho levels. We linked the NHANES data to the National Death Index to determine participants’ survival status. End of follow-up was participants’ death date or December 31, 2019.ResultsWe observed that males, current smokers, older age, higher body mass index, and lower estimated glomerular filtration rate correlated to lower α-klotho levels, while hepatitis C virus infection correlated to higher α-klotho. The population mortality rate was 11.8 per 10,000 person-months (1,490 deaths); group 1 (the first septile) had higher mortality risk compared with group 2 through group 7. By weighted Cox regression with adjustment for potential confounders, we found that group 2 through group 6, but not group 7, were associated with 25% to 35% lower risk of all-cause mortality compared with group 1. When compared with group 4, we observed that both group 1 (HR: 1.46, 95% CI 1.13-1.88) and group 7 (HR: 1.38, 95% CI 1.09-1.74) were associated with higher mortality risk.ConclusionIn summary, among middle-aged and older U.S. adults, we observed a non-linear association between soluble α-klotho and all-cause mortality, with individuals at the two extremes at increased risk of death.https://www.frontiersin.org/articles/10.3389/fendo.2023.1246590/fullklothoagingall-cause mortalitychronic kidney disease (CKD)hepatitis C virus (HCV) |
| spellingShingle | Min-Hsiang Chuang Hung-Wei Wang Yun-Ting Huang Ming-Yan Jiang Ming-Yan Jiang Association between soluble α-klotho and mortality risk in middle-aged and older adults Frontiers in Endocrinology klotho aging all-cause mortality chronic kidney disease (CKD) hepatitis C virus (HCV) |
| title | Association between soluble α-klotho and mortality risk in middle-aged and older adults |
| title_full | Association between soluble α-klotho and mortality risk in middle-aged and older adults |
| title_fullStr | Association between soluble α-klotho and mortality risk in middle-aged and older adults |
| title_full_unstemmed | Association between soluble α-klotho and mortality risk in middle-aged and older adults |
| title_short | Association between soluble α-klotho and mortality risk in middle-aged and older adults |
| title_sort | association between soluble α klotho and mortality risk in middle aged and older adults |
| topic | klotho aging all-cause mortality chronic kidney disease (CKD) hepatitis C virus (HCV) |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1246590/full |
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