ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW)
The present review describes the mechanisms of benign prostatic hyperplasia (BPH) development in patients with metabolic syndrome (MS) and its association with androgen deficiency, which is frequently observed in these patients. We cover the data indicating that despite a reduced serum level of test...
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| Format: | Article |
| Language: | Russian |
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ABV-press
2017-11-01
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| Series: | Андрология и генитальная хирургия |
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| Online Access: | https://agx.abvpress.ru/jour/article/view/242 |
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| author | V. I. Kirpatovskiy E. V. Frolova O. N. Nadtochiy O. S. Chochuev A. V. Kazachenko |
| author_facet | V. I. Kirpatovskiy E. V. Frolova O. N. Nadtochiy O. S. Chochuev A. V. Kazachenko |
| author_sort | V. I. Kirpatovskiy |
| collection | DOAJ |
| description | The present review describes the mechanisms of benign prostatic hyperplasia (BPH) development in patients with metabolic syndrome (MS) and its association with androgen deficiency, which is frequently observed in these patients. We cover the data indicating that despite a reduced serum level of testosterone in patients with MS, they are more likely to be diagnosed with BPH, have more significant prostate enlargement, more rapid BPH progression, as well as deterioration of urination problems compared to patients of similar age without MS. The following factors are considered to trigger BPH in patients with MS: changes in the tissue metabolism of sex hormones with increased androgens and estrogens concentrations in the prostate gland despite the reduced serum androgen levels, relative prevalence of the estrogenic effects, chronic pelvic ischemia, stimulation of prostate cells proliferation due to the elevated insulin level and the increased secretion of growth factors, and developing chronic low-intensity inflammation. Specific features of BPH pathogenesis in individuals with MS suggest a correction of therapeutic approaches to BPH in such cases, because conventional therapy in patients with BPH and MS is less effective than in patients with BPH only. |
| first_indexed | 2024-04-10T03:53:18Z |
| format | Article |
| id | doaj.art-f151260047fc44ed9ef6f1e43300bc8a |
| institution | Directory Open Access Journal |
| issn | 2070-9781 |
| language | Russian |
| last_indexed | 2024-04-10T03:53:18Z |
| publishDate | 2017-11-01 |
| publisher | ABV-press |
| record_format | Article |
| series | Андрология и генитальная хирургия |
| spelling | doaj.art-f151260047fc44ed9ef6f1e43300bc8a2023-03-13T07:15:08ZrusABV-pressАндрология и генитальная хирургия2070-97812017-11-01183101910.17650/2070-9781-2017-18-3-10-19227ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW)V. I. Kirpatovskiy0E. V. Frolova1O. N. Nadtochiy2O. S. Chochuev3A. V. Kazachenko4N.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaN.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaN.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaN.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaN.A.Lopatkin Scientific Research Institute of Urology and Interventional Radiology – branch of the National Medical Research Radiology Center, Ministry of Health of RussiaThe present review describes the mechanisms of benign prostatic hyperplasia (BPH) development in patients with metabolic syndrome (MS) and its association with androgen deficiency, which is frequently observed in these patients. We cover the data indicating that despite a reduced serum level of testosterone in patients with MS, they are more likely to be diagnosed with BPH, have more significant prostate enlargement, more rapid BPH progression, as well as deterioration of urination problems compared to patients of similar age without MS. The following factors are considered to trigger BPH in patients with MS: changes in the tissue metabolism of sex hormones with increased androgens and estrogens concentrations in the prostate gland despite the reduced serum androgen levels, relative prevalence of the estrogenic effects, chronic pelvic ischemia, stimulation of prostate cells proliferation due to the elevated insulin level and the increased secretion of growth factors, and developing chronic low-intensity inflammation. Specific features of BPH pathogenesis in individuals with MS suggest a correction of therapeutic approaches to BPH in such cases, because conventional therapy in patients with BPH and MS is less effective than in patients with BPH only.https://agx.abvpress.ru/jour/article/view/242metabolic syndromeandrogen deficiencybenign prostatic hyperplasiapathogenesischronic ischemiainsulin resistancechronic low-intensity inflammation |
| spellingShingle | V. I. Kirpatovskiy E. V. Frolova O. N. Nadtochiy O. S. Chochuev A. V. Kazachenko ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) Андрология и генитальная хирургия metabolic syndrome androgen deficiency benign prostatic hyperplasia pathogenesis chronic ischemia insulin resistance chronic low-intensity inflammation |
| title | ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) |
| title_full | ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) |
| title_fullStr | ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) |
| title_full_unstemmed | ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) |
| title_short | ANDROGEN DEFICIENCY AND PROGRESSION OF BENIGN PROSTATIC HYPERPLASIA IN PATIENTS WITH METABOLIC SYNDROME: IS THERE ANY CONTROVERSY? (A LITERATURE REVIEW) |
| title_sort | androgen deficiency and progression of benign prostatic hyperplasia in patients with metabolic syndrome is there any controversy a literature review |
| topic | metabolic syndrome androgen deficiency benign prostatic hyperplasia pathogenesis chronic ischemia insulin resistance chronic low-intensity inflammation |
| url | https://agx.abvpress.ru/jour/article/view/242 |
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