Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface
As a structural, catalytic, and signaling component, zinc is necessary for the growth and development of plants, animals, and microorganisms. Zinc is also essential for the growth of pathogenic microorganisms and is involved in their metabolism as well as the regulation of various virulence factors....
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| Format: | Article |
| Language: | English |
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Frontiers Media S.A.
2021-09-01
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| Series: | Frontiers in Microbiology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fmicb.2021.741873/full |
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| author | Shuaitao Wang Juanli Cheng Juanli Cheng Yanting Niu Panxin Li Xiangqian Zhang Xiangqian Zhang Jinshui Lin Jinshui Lin |
| author_facet | Shuaitao Wang Juanli Cheng Juanli Cheng Yanting Niu Panxin Li Xiangqian Zhang Xiangqian Zhang Jinshui Lin Jinshui Lin |
| author_sort | Shuaitao Wang |
| collection | DOAJ |
| description | As a structural, catalytic, and signaling component, zinc is necessary for the growth and development of plants, animals, and microorganisms. Zinc is also essential for the growth of pathogenic microorganisms and is involved in their metabolism as well as the regulation of various virulence factors. Additionally, zinc is necessary for infection and colonization of pathogenic microorganisms in the host. Upon infection in healthy organisms, the host sequesters zinc both intracellularly and extracellularly to enhance the immune response and prevent the proliferation and infection of the pathogen. Intracellularly, the host manipulates zinc levels through Zrt/Irt-like protein (ZIP)/ZnT family proteins and various zinc storage proteins. Extracellularly, members of the S100 protein family, such as calgranulin C, sequester zinc to inhibit microbial growth. In the face of these nutritional limitations, bacteria rely on an efficient zinc transport system to maintain zinc supplementation for proliferation and disruption of the host defense system to establish infection. Here, we summarize the strategies for zinc uptake in conditional pathogenic Pseudomonas aeruginosa, including known zinc uptake systems (ZnuABC, HmtA, and ZrmABCD) and the zinc uptake regulator (Zur). In addition, other potential zinc uptake pathways were analyzed. This review systematically summarizes the process of zinc uptake by P. aeruginosa to provide guidance for the development of new drug targets. |
| first_indexed | 2024-12-17T01:14:22Z |
| format | Article |
| id | doaj.art-f151e4786bd94b319d2964d225fdfe98 |
| institution | Directory Open Access Journal |
| issn | 1664-302X |
| language | English |
| last_indexed | 2024-12-17T01:14:22Z |
| publishDate | 2021-09-01 |
| publisher | Frontiers Media S.A. |
| record_format | Article |
| series | Frontiers in Microbiology |
| spelling | doaj.art-f151e4786bd94b319d2964d225fdfe982022-12-21T22:09:03ZengFrontiers Media S.A.Frontiers in Microbiology1664-302X2021-09-011210.3389/fmicb.2021.741873741873Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen InterfaceShuaitao Wang0Juanli Cheng1Juanli Cheng2Yanting Niu3Panxin Li4Xiangqian Zhang5Xiangqian Zhang6Jinshui Lin7Jinshui Lin8College of Life Sciences, Yan’an University, Yan’an, ChinaCollege of Life Sciences, Yan’an University, Yan’an, ChinaShaanxi Key Laboratory of Chinese Jujube, Yan’an University, Yan’an, ChinaCollege of Life Sciences, Yan’an University, Yan’an, ChinaCollege of Life Sciences, Yan’an University, Yan’an, ChinaCollege of Life Sciences, Yan’an University, Yan’an, ChinaShaanxi Key Laboratory of Chinese Jujube, Yan’an University, Yan’an, ChinaCollege of Life Sciences, Yan’an University, Yan’an, ChinaShaanxi Key Laboratory of Chinese Jujube, Yan’an University, Yan’an, ChinaAs a structural, catalytic, and signaling component, zinc is necessary for the growth and development of plants, animals, and microorganisms. Zinc is also essential for the growth of pathogenic microorganisms and is involved in their metabolism as well as the regulation of various virulence factors. Additionally, zinc is necessary for infection and colonization of pathogenic microorganisms in the host. Upon infection in healthy organisms, the host sequesters zinc both intracellularly and extracellularly to enhance the immune response and prevent the proliferation and infection of the pathogen. Intracellularly, the host manipulates zinc levels through Zrt/Irt-like protein (ZIP)/ZnT family proteins and various zinc storage proteins. Extracellularly, members of the S100 protein family, such as calgranulin C, sequester zinc to inhibit microbial growth. In the face of these nutritional limitations, bacteria rely on an efficient zinc transport system to maintain zinc supplementation for proliferation and disruption of the host defense system to establish infection. Here, we summarize the strategies for zinc uptake in conditional pathogenic Pseudomonas aeruginosa, including known zinc uptake systems (ZnuABC, HmtA, and ZrmABCD) and the zinc uptake regulator (Zur). In addition, other potential zinc uptake pathways were analyzed. This review systematically summarizes the process of zinc uptake by P. aeruginosa to provide guidance for the development of new drug targets.https://www.frontiersin.org/articles/10.3389/fmicb.2021.741873/fullPseudomonas aeruginosazinc uptake systemZurzincophorenutritional immunity |
| spellingShingle | Shuaitao Wang Juanli Cheng Juanli Cheng Yanting Niu Panxin Li Xiangqian Zhang Xiangqian Zhang Jinshui Lin Jinshui Lin Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface Frontiers in Microbiology Pseudomonas aeruginosa zinc uptake system Zur zincophore nutritional immunity |
| title | Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface |
| title_full | Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface |
| title_fullStr | Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface |
| title_full_unstemmed | Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface |
| title_short | Strategies for Zinc Uptake in Pseudomonas aeruginosa at the Host–Pathogen Interface |
| title_sort | strategies for zinc uptake in pseudomonas aeruginosa at the host pathogen interface |
| topic | Pseudomonas aeruginosa zinc uptake system Zur zincophore nutritional immunity |
| url | https://www.frontiersin.org/articles/10.3389/fmicb.2021.741873/full |
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