Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy
Xinquan Yang,* Peilong Liu,* Yan Zhang, Jun Lu, Hongmou Zhao Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongmou Zhao, Dep...
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| Format: | Article |
| Language: | English |
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Dove Medical Press
2023-11-01
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| Series: | International Journal of Nanomedicine |
| Subjects: | |
| Online Access: | https://www.dovepress.com/bioprinting-enabled-biomaterials-a-cutting-edge-strategy-for-future-os-peer-reviewed-fulltext-article-IJN |
| _version_ | 1827774019615588352 |
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| author | Yang X Liu P Zhang Y Lu J Zhao H |
| author_facet | Yang X Liu P Zhang Y Lu J Zhao H |
| author_sort | Yang X |
| collection | DOAJ |
| description | Xinquan Yang,* Peilong Liu,* Yan Zhang, Jun Lu, Hongmou Zhao Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongmou Zhao, Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China, Email zhaohongmou@xiyi.edu.cnAbstract: Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.Graphical Abstract: Keywords: drug delivery, bioprinting, osteoarthritis, biomaterials, translation |
| first_indexed | 2024-03-11T13:32:02Z |
| format | Article |
| id | doaj.art-f155756a01124af699f27a1465fc651f |
| institution | Directory Open Access Journal |
| issn | 1178-2013 |
| language | English |
| last_indexed | 2024-03-11T13:32:02Z |
| publishDate | 2023-11-01 |
| publisher | Dove Medical Press |
| record_format | Article |
| series | International Journal of Nanomedicine |
| spelling | doaj.art-f155756a01124af699f27a1465fc651f2023-11-02T17:13:57ZengDove Medical PressInternational Journal of Nanomedicine1178-20132023-11-01Volume 186213623287784Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis TherapyYang XLiu PZhang YLu JZhao HXinquan Yang,* Peilong Liu,* Yan Zhang, Jun Lu, Hongmou Zhao Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China*These authors contributed equally to this workCorrespondence: Hongmou Zhao, Department of Foot and Ankle Surgery, Honghui Hospital of Xi’an Jiaotong University, Xi’an, Shaanxi, 710054, People’s Republic of China, Email zhaohongmou@xiyi.edu.cnAbstract: Bioprinting is an advanced technology that allows for the precise placement of cells and biomaterials in a controlled manner, making significant contributions in regenerative medicine. Notably, bioprinting-enabled biomaterials have found extensive application as drug delivery systems (DDS) in the treatment of osteoarthritis (OA). Despite the widespread utilization of these biomaterials, there has been limited comprehensive research summarizing the recent advances in this area. Therefore, this review aims to explore the noteworthy developments and challenges associated with utilizing bioprinting-enabled biomaterials as effective DDS for the treatment of OA. To begin, we provide an overview of the complex pathophysiology of OA, highlighting the shortcomings of current treatment modalities. Following this, we conduct a detailed examination of various bioprinting technologies and discuss the wide range of biomaterials employed in DDS applications for OA therapy. Finally, by placing emphasis on their transformative potential, we discuss the incorporation of crucial cellular components such as chondrocytes and mesenchymal stem cells into bioprinted constructs, which play a pivotal role in promoting tissue regeneration and repair.Graphical Abstract: Keywords: drug delivery, bioprinting, osteoarthritis, biomaterials, translationhttps://www.dovepress.com/bioprinting-enabled-biomaterials-a-cutting-edge-strategy-for-future-os-peer-reviewed-fulltext-article-IJNdrug deliverybioprintingosteoarthritisbiomaterialstranslation |
| spellingShingle | Yang X Liu P Zhang Y Lu J Zhao H Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy International Journal of Nanomedicine drug delivery bioprinting osteoarthritis biomaterials translation |
| title | Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy |
| title_full | Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy |
| title_fullStr | Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy |
| title_full_unstemmed | Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy |
| title_short | Bioprinting-Enabled Biomaterials: A Cutting-Edge Strategy for Future Osteoarthritis Therapy |
| title_sort | bioprinting enabled biomaterials a cutting edge strategy for future osteoarthritis therapy |
| topic | drug delivery bioprinting osteoarthritis biomaterials translation |
| url | https://www.dovepress.com/bioprinting-enabled-biomaterials-a-cutting-edge-strategy-for-future-os-peer-reviewed-fulltext-article-IJN |
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