Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning
New advances in materials science and medicine have enabled the development of new and increasingly sophisticated biomaterials. One of the most widely used biopolymers is polycaprolactone (PCL) because it has properties suitable for biomedical applications, tissue engineering scaffolds, or drug deli...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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MDPI AG
2024-01-01
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| Series: | Biomimetics |
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| Online Access: | https://www.mdpi.com/2313-7673/9/2/70 |
| _version_ | 1797298859826741248 |
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| author | Manuel Rodríguez-Martín José Manuel Aguilar Daniel Castro-Criado Alberto Romero |
| author_facet | Manuel Rodríguez-Martín José Manuel Aguilar Daniel Castro-Criado Alberto Romero |
| author_sort | Manuel Rodríguez-Martín |
| collection | DOAJ |
| description | New advances in materials science and medicine have enabled the development of new and increasingly sophisticated biomaterials. One of the most widely used biopolymers is polycaprolactone (PCL) because it has properties suitable for biomedical applications, tissue engineering scaffolds, or drug delivery systems. However, PCL scaffolds do not have adequate bioactivity, and therefore, alternatives have been studied, such as mixing PCL with bioactive polymers such as gelatin, to promote cell growth. Thus, this work will deal with the fabrication of nanofiber membranes by means of the electrospinning technique using PCL-based solutions (12 wt.% and 20 wt.%) and PCL with gelatin (12 wt.% and 8 wt.%, respectively). Formic acid and acetic acid, as well as mixtures of both in different proportions, have been used to prepare the preliminary solutions, thus supporting the electrospinning process by controlling the viscosity of the solutions and, therefore, the size and uniformity of the fibers. The physical properties of the solutions and the morphological, mechanical, and thermal properties of the membranes were evaluated. Results demonstrate that it is possible to achieve the determined properties of the samples with an appropriate selection of polymer concentrations as well as solvents. |
| first_indexed | 2024-03-07T22:41:09Z |
| format | Article |
| id | doaj.art-f1587d7c3de34903b37ad1599423708c |
| institution | Directory Open Access Journal |
| issn | 2313-7673 |
| language | English |
| last_indexed | 2024-03-07T22:41:09Z |
| publishDate | 2024-01-01 |
| publisher | MDPI AG |
| record_format | Article |
| series | Biomimetics |
| spelling | doaj.art-f1587d7c3de34903b37ad1599423708c2024-02-23T15:09:00ZengMDPI AGBiomimetics2313-76732024-01-01927010.3390/biomimetics9020070Characterization of Gelatin-Polycaprolactone Membranes by ElectrospinningManuel Rodríguez-Martín0José Manuel Aguilar1Daniel Castro-Criado2Alberto Romero3Department of Chemical Engineering, Faculty of Chemistry, University of Seville, 41012 Seville, SpainDepartment of Chemical Engineering, Faculty of Chemistry, University of Seville, 41012 Seville, SpainDepartment of Chemical Engineering, Faculty of Chemistry, University of Seville, 41012 Seville, SpainDepartment of Chemical Engineering, Faculty of Chemistry, University of Seville, 41012 Seville, SpainNew advances in materials science and medicine have enabled the development of new and increasingly sophisticated biomaterials. One of the most widely used biopolymers is polycaprolactone (PCL) because it has properties suitable for biomedical applications, tissue engineering scaffolds, or drug delivery systems. However, PCL scaffolds do not have adequate bioactivity, and therefore, alternatives have been studied, such as mixing PCL with bioactive polymers such as gelatin, to promote cell growth. Thus, this work will deal with the fabrication of nanofiber membranes by means of the electrospinning technique using PCL-based solutions (12 wt.% and 20 wt.%) and PCL with gelatin (12 wt.% and 8 wt.%, respectively). Formic acid and acetic acid, as well as mixtures of both in different proportions, have been used to prepare the preliminary solutions, thus supporting the electrospinning process by controlling the viscosity of the solutions and, therefore, the size and uniformity of the fibers. The physical properties of the solutions and the morphological, mechanical, and thermal properties of the membranes were evaluated. Results demonstrate that it is possible to achieve the determined properties of the samples with an appropriate selection of polymer concentrations as well as solvents.https://www.mdpi.com/2313-7673/9/2/70tissue engineeringscaffoldspolycaprolactonegelatinnanofiber membranesbiomaterials |
| spellingShingle | Manuel Rodríguez-Martín José Manuel Aguilar Daniel Castro-Criado Alberto Romero Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning Biomimetics tissue engineering scaffolds polycaprolactone gelatin nanofiber membranes biomaterials |
| title | Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning |
| title_full | Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning |
| title_fullStr | Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning |
| title_full_unstemmed | Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning |
| title_short | Characterization of Gelatin-Polycaprolactone Membranes by Electrospinning |
| title_sort | characterization of gelatin polycaprolactone membranes by electrospinning |
| topic | tissue engineering scaffolds polycaprolactone gelatin nanofiber membranes biomaterials |
| url | https://www.mdpi.com/2313-7673/9/2/70 |
| work_keys_str_mv | AT manuelrodriguezmartin characterizationofgelatinpolycaprolactonemembranesbyelectrospinning AT josemanuelaguilar characterizationofgelatinpolycaprolactonemembranesbyelectrospinning AT danielcastrocriado characterizationofgelatinpolycaprolactonemembranesbyelectrospinning AT albertoromero characterizationofgelatinpolycaprolactonemembranesbyelectrospinning |