p27<sup>kip1</sup>: a target for tumor therapies?
<p>Abstract</p> <p>The cyclin kinase inhibitor p27<sup>kip1 </sup>acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to differen...
| Main Authors: | , , , |
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| Format: | Article |
| Language: | English |
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BMC
2007-05-01
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| Series: | Cell Division |
| Online Access: | http://www.celldiv.com/content/2/1/13 |
| _version_ | 1828259091808518144 |
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| author | Kossatz Uta Zender Steffen Nickeleit Irina Malek Nisar P |
| author_facet | Kossatz Uta Zender Steffen Nickeleit Irina Malek Nisar P |
| author_sort | Kossatz Uta |
| collection | DOAJ |
| description | <p>Abstract</p> <p>The cyclin kinase inhibitor p27<sup>kip1 </sup>acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to different treatment modalities. In contrast to other tumor suppressor proteins p27 expression levels in tumor cells are frequently regulated by ubiquitin dependent proteolysis. Re-expression of p27 in cancer cells therefore does not require gene therapy but can be achieved by interfering with the protein turnover machinery. In this review we will summarize experimental results which highlight the potential use of p27 as a target for oncological therapies.</p> |
| first_indexed | 2024-04-13T03:02:35Z |
| format | Article |
| id | doaj.art-f15b2a10c6be4408aa130e13854ce94b |
| institution | Directory Open Access Journal |
| issn | 1747-1028 |
| language | English |
| last_indexed | 2024-04-13T03:02:35Z |
| publishDate | 2007-05-01 |
| publisher | BMC |
| record_format | Article |
| series | Cell Division |
| spelling | doaj.art-f15b2a10c6be4408aa130e13854ce94b2022-12-22T03:05:23ZengBMCCell Division1747-10282007-05-01211310.1186/1747-1028-2-13p27<sup>kip1</sup>: a target for tumor therapies?Kossatz UtaZender SteffenNickeleit IrinaMalek Nisar P<p>Abstract</p> <p>The cyclin kinase inhibitor p27<sup>kip1 </sup>acts as a potent tumor supressor protein in a variety of human cancers. Its expression levels correlate closely with the overall prognosis of the affected patient and often predict the outcome to different treatment modalities. In contrast to other tumor suppressor proteins p27 expression levels in tumor cells are frequently regulated by ubiquitin dependent proteolysis. Re-expression of p27 in cancer cells therefore does not require gene therapy but can be achieved by interfering with the protein turnover machinery. In this review we will summarize experimental results which highlight the potential use of p27 as a target for oncological therapies.</p>http://www.celldiv.com/content/2/1/13 |
| spellingShingle | Kossatz Uta Zender Steffen Nickeleit Irina Malek Nisar P p27<sup>kip1</sup>: a target for tumor therapies? Cell Division |
| title | p27<sup>kip1</sup>: a target for tumor therapies? |
| title_full | p27<sup>kip1</sup>: a target for tumor therapies? |
| title_fullStr | p27<sup>kip1</sup>: a target for tumor therapies? |
| title_full_unstemmed | p27<sup>kip1</sup>: a target for tumor therapies? |
| title_short | p27<sup>kip1</sup>: a target for tumor therapies? |
| title_sort | p27 sup kip1 sup a target for tumor therapies |
| url | http://www.celldiv.com/content/2/1/13 |
| work_keys_str_mv | AT kossatzuta p27supkip1supatargetfortumortherapies AT zendersteffen p27supkip1supatargetfortumortherapies AT nickeleitirina p27supkip1supatargetfortumortherapies AT maleknisarp p27supkip1supatargetfortumortherapies |