Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006
IntroductionExisting evidence suggests an association between certain vitamins and metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of multivitamin co-exposure on MetS. This study aims to investigate the associations of the individual or multiple water-soluble v...
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Frontiers Media S.A.
2023-05-01
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| Series: | Frontiers in Endocrinology |
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| Online Access: | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167317/full |
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| author | Xun Pei Junjie Yao Simiao Ran Simiao Ran Haifei Lu Shuo Yang Yini Zhang Miyuan Wang Heyuan Shi Aihua Tan Aihua Tan Aihua Tan |
| author_facet | Xun Pei Junjie Yao Simiao Ran Simiao Ran Haifei Lu Shuo Yang Yini Zhang Miyuan Wang Heyuan Shi Aihua Tan Aihua Tan Aihua Tan |
| author_sort | Xun Pei |
| collection | DOAJ |
| description | IntroductionExisting evidence suggests an association between certain vitamins and metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of multivitamin co-exposure on MetS. This study aims to investigate the associations of the individual or multiple water-soluble vitamins (i.e., vitamin C (VC), vitamin B9 (VB9), and vitamin B12 (VB12)) with co-exposure to MetS, as well as the dose-response relationships among them.MethodsA cross-sectional study was conducted by employing the National Health and Examination Surveys (NHANESs) 2003-2006. Multivariate-adjusted logistic regression models were used to explore the association between individual serum water-soluble vitamins and the risk of MetS and its components, including waist circumference, triglyceride, high-density lipoprotein, blood pressure, and fasting plasma glucose. Restricted cubic splines were performed to explore the dose-response relationships among them. The quantile g-computation method was adopted to explore the associations of multiple water-soluble vitamins co-exposure with MetS risk and MetS components.ResultsA total of 8983 subjects were involved in the study, of whom 1443 were diagnosed with MetS. The MetS groups had a higher proportion of participants with age ≥60 years, BMI ≥30 kg/m2, and insufficient physical activity. Compared with the lowest quartile, the third (OR=0.67, 95% CI: 0.48, 0.94) and highest quartiles (OR=0.52, 95%CI: 0.35, 0.76) of VC were associated with lower MetS risk. Restricted cubic splines showed negative dose-response relationships among VC, VB9 and VB12, and MetS. Regarding MetS components, higher VC quartiles were associated with lower waist circumference, triglyceride, blood pressure, and fasting plasma glucose, while higher VC and VB9 quartiles were associated with higher high-density lipoprotein (HDL). Co-exposure to VC, VB9, and VB12 was significantly inversely associated with MetS, with ORs (95% CI) of 0.81 (0.74, 0.89) and 0.84 (0.78, 0.90) in the conditional and marginal structural models, respectively. Furthermore, we found that VC, VB9, and VB12 co-exposure were negatively associated with waist circumference and blood pressure, while VC, VB9, and VB12 co-exposure were positively associated with HDL.ConclusionThis study revealed negative associations of VC, VB9, and VB12 with MetS, while the high water-soluble vitamin co-exposure was associated with a lower MetS risk. |
| first_indexed | 2024-04-09T13:12:56Z |
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| id | doaj.art-f15b82cd541b408aa319a2a3a8dfce5d |
| institution | Directory Open Access Journal |
| issn | 1664-2392 |
| language | English |
| last_indexed | 2024-04-09T13:12:56Z |
| publishDate | 2023-05-01 |
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| series | Frontiers in Endocrinology |
| spelling | doaj.art-f15b82cd541b408aa319a2a3a8dfce5d2023-05-12T06:15:41ZengFrontiers Media S.A.Frontiers in Endocrinology1664-23922023-05-011410.3389/fendo.2023.11673171167317Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006Xun Pei0Junjie Yao1Simiao Ran2Simiao Ran3Haifei Lu4Shuo Yang5Yini Zhang6Miyuan Wang7Heyuan Shi8Aihua Tan9Aihua Tan10Aihua Tan11Hubei Provincial Hospital of TCM (Affiliated Hospital of Hubei University of Chinese Medicine), Wuhan, Hubei, ChinaCollege of Acupuncture and Tuina, Changchun University of Chinese Medicine, Changchun, Jilin, ChinaDepartment of Gastroenterology, HuangGang Hospital of Traditional Chinese Medicine (TCM), Affiliated to Hubei University of Chinese Medicine, Huanggang, Hubei, ChinaBasic Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaBasic Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaDepartment of Gastroenterology, HuangGang Hospital of Traditional Chinese Medicine (TCM), Affiliated to Hubei University of Chinese Medicine, Huanggang, Hubei, ChinaBasic Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaSchool of Management Beijing, University of Chinese Medicine, Beijing, ChinaBasic Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaDepartment of Gastroenterology, HuangGang Hospital of Traditional Chinese Medicine (TCM), Affiliated to Hubei University of Chinese Medicine, Huanggang, Hubei, ChinaBasic Medicine College, Hubei University of Chinese Medicine, Wuhan, Hubei, ChinaDongzhimen Hospital of Beijing University of Chinese Medicine / Postdoctoral Station of Beijing University of Chinese Medicine, Beijing, ChinaIntroductionExisting evidence suggests an association between certain vitamins and metabolic syndrome (MetS), but few epidemiological studies have focused on the effects of multivitamin co-exposure on MetS. This study aims to investigate the associations of the individual or multiple water-soluble vitamins (i.e., vitamin C (VC), vitamin B9 (VB9), and vitamin B12 (VB12)) with co-exposure to MetS, as well as the dose-response relationships among them.MethodsA cross-sectional study was conducted by employing the National Health and Examination Surveys (NHANESs) 2003-2006. Multivariate-adjusted logistic regression models were used to explore the association between individual serum water-soluble vitamins and the risk of MetS and its components, including waist circumference, triglyceride, high-density lipoprotein, blood pressure, and fasting plasma glucose. Restricted cubic splines were performed to explore the dose-response relationships among them. The quantile g-computation method was adopted to explore the associations of multiple water-soluble vitamins co-exposure with MetS risk and MetS components.ResultsA total of 8983 subjects were involved in the study, of whom 1443 were diagnosed with MetS. The MetS groups had a higher proportion of participants with age ≥60 years, BMI ≥30 kg/m2, and insufficient physical activity. Compared with the lowest quartile, the third (OR=0.67, 95% CI: 0.48, 0.94) and highest quartiles (OR=0.52, 95%CI: 0.35, 0.76) of VC were associated with lower MetS risk. Restricted cubic splines showed negative dose-response relationships among VC, VB9 and VB12, and MetS. Regarding MetS components, higher VC quartiles were associated with lower waist circumference, triglyceride, blood pressure, and fasting plasma glucose, while higher VC and VB9 quartiles were associated with higher high-density lipoprotein (HDL). Co-exposure to VC, VB9, and VB12 was significantly inversely associated with MetS, with ORs (95% CI) of 0.81 (0.74, 0.89) and 0.84 (0.78, 0.90) in the conditional and marginal structural models, respectively. Furthermore, we found that VC, VB9, and VB12 co-exposure were negatively associated with waist circumference and blood pressure, while VC, VB9, and VB12 co-exposure were positively associated with HDL.ConclusionThis study revealed negative associations of VC, VB9, and VB12 with MetS, while the high water-soluble vitamin co-exposure was associated with a lower MetS risk.https://www.frontiersin.org/articles/10.3389/fendo.2023.1167317/fullvitaminmetabolic syndromeweighted quantile sum regressionNHANESco-exposure |
| spellingShingle | Xun Pei Junjie Yao Simiao Ran Simiao Ran Haifei Lu Shuo Yang Yini Zhang Miyuan Wang Heyuan Shi Aihua Tan Aihua Tan Aihua Tan Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 Frontiers in Endocrinology vitamin metabolic syndrome weighted quantile sum regression NHANES co-exposure |
| title | Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 |
| title_full | Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 |
| title_fullStr | Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 |
| title_full_unstemmed | Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 |
| title_short | Association of serum water-soluble vitamin exposures with the risk of metabolic syndrome: results from NHANES 2003-2006 |
| title_sort | association of serum water soluble vitamin exposures with the risk of metabolic syndrome results from nhanes 2003 2006 |
| topic | vitamin metabolic syndrome weighted quantile sum regression NHANES co-exposure |
| url | https://www.frontiersin.org/articles/10.3389/fendo.2023.1167317/full |
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