Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia
Aim: Magnetic hydrogels (MHGs) have been proposed to avoid the redistribution and loss of magnetic nanoparticles (MNPs) when administrated by intratumoral injection. However, the requirement of complex cooling systems and temperature monitoring systems still hinder the clinical application of MHGs....
| Main Authors: | , , , , , , , |
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| Format: | Article |
| Language: | English |
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Taylor & Francis Group
2021-01-01
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| Series: | International Journal of Hyperthermia |
| Subjects: | |
| Online Access: | http://dx.doi.org/10.1080/02656736.2020.1863479 |
| _version_ | 1819096807030915072 |
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| author | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Heng Li Li Yu Yu-Xiang Zhang Ren-Peng Yang Wei Zhang |
| author_facet | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Heng Li Li Yu Yu-Xiang Zhang Ren-Peng Yang Wei Zhang |
| author_sort | Shuai-Wen Ding |
| collection | DOAJ |
| description | Aim: Magnetic hydrogels (MHGs) have been proposed to avoid the redistribution and loss of magnetic nanoparticles (MNPs) when administrated by intratumoral injection. However, the requirement of complex cooling systems and temperature monitoring systems still hinder the clinical application of MHGs. This study investigates the feasibility of developing an MHG to realize the self-regulation of hyperthermia temperature. Methods: The MHG was developed by dispersing the MNPs with self-regulating temperature property into the temperature-sensitive hydrogel through physical crosslinking. The MHG's gelation temperature was tested by measuring the storage modulus and loss modulus on a rotational rheometer. The biocompatibility of the MHG and MNPs was characterized by CCK-8 assay against HaCaT cells. The in vivo magnetic heating property was examined through monitoring the temperature in the MHG on mice back upon the application of the alternating magnetic field (400 ± 5 Oe, 100 ± 5 kHz) every week for successive six weeks. Results: The gelation temperature of the MHG falls in 28.4°C-37.4°C. At in vivo applied concentration of 80 mg/mL, the MHG exhibits over 80% cell viability after 72 h, significantly higher than 50% cell viability of the MNPs (p<0.001). The MHG's stable magnetic hyperthermia temperatures in vivo are in the range of 43.4°C–43.8°C. Conclusions: The developed MHG can be injected using a syringe and will solidify upon body temperature. The biocompatibility is improved after the MNPs being made into MHG. The MHG can self-regulate the temperature for six weeks, exhibiting application potential for self-regulating temperature hyperthermia. |
| first_indexed | 2024-12-22T00:05:03Z |
| format | Article |
| id | doaj.art-f15c501a0709405fbafe17f7b877dc7a |
| institution | Directory Open Access Journal |
| issn | 0265-6736 1464-5157 |
| language | English |
| last_indexed | 2024-12-22T00:05:03Z |
| publishDate | 2021-01-01 |
| publisher | Taylor & Francis Group |
| record_format | Article |
| series | International Journal of Hyperthermia |
| spelling | doaj.art-f15c501a0709405fbafe17f7b877dc7a2022-12-21T18:45:35ZengTaylor & Francis GroupInternational Journal of Hyperthermia0265-67361464-51572021-01-01381132110.1080/02656736.2020.18634791863479Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermiaShuai-Wen Ding0Cheng-Wei Wu1Xiao-Gang Yu2Heng Li3Li Yu4Yu-Xiang Zhang5Ren-Peng Yang6Wei Zhang7State Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyState Key Laboratory of Structural Analysis for Industrial Equipment, Department of Engineering Mechanics, Dalian University of TechnologyAim: Magnetic hydrogels (MHGs) have been proposed to avoid the redistribution and loss of magnetic nanoparticles (MNPs) when administrated by intratumoral injection. However, the requirement of complex cooling systems and temperature monitoring systems still hinder the clinical application of MHGs. This study investigates the feasibility of developing an MHG to realize the self-regulation of hyperthermia temperature. Methods: The MHG was developed by dispersing the MNPs with self-regulating temperature property into the temperature-sensitive hydrogel through physical crosslinking. The MHG's gelation temperature was tested by measuring the storage modulus and loss modulus on a rotational rheometer. The biocompatibility of the MHG and MNPs was characterized by CCK-8 assay against HaCaT cells. The in vivo magnetic heating property was examined through monitoring the temperature in the MHG on mice back upon the application of the alternating magnetic field (400 ± 5 Oe, 100 ± 5 kHz) every week for successive six weeks. Results: The gelation temperature of the MHG falls in 28.4°C-37.4°C. At in vivo applied concentration of 80 mg/mL, the MHG exhibits over 80% cell viability after 72 h, significantly higher than 50% cell viability of the MNPs (p<0.001). The MHG's stable magnetic hyperthermia temperatures in vivo are in the range of 43.4°C–43.8°C. Conclusions: The developed MHG can be injected using a syringe and will solidify upon body temperature. The biocompatibility is improved after the MNPs being made into MHG. The MHG can self-regulate the temperature for six weeks, exhibiting application potential for self-regulating temperature hyperthermia.http://dx.doi.org/10.1080/02656736.2020.1863479magnetic hydrogelmagnetic nanoparticleshyperthermiaself-regulating temperature; biocompatibility |
| spellingShingle | Shuai-Wen Ding Cheng-Wei Wu Xiao-Gang Yu Heng Li Li Yu Yu-Xiang Zhang Ren-Peng Yang Wei Zhang Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia International Journal of Hyperthermia magnetic hydrogel magnetic nanoparticles hyperthermia self-regulating temperature; biocompatibility |
| title | Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia |
| title_full | Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia |
| title_fullStr | Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia |
| title_full_unstemmed | Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia |
| title_short | Magnetic hydrogel with long in situ retention time for self-regulating temperature hyperthermia |
| title_sort | magnetic hydrogel with long in situ retention time for self regulating temperature hyperthermia |
| topic | magnetic hydrogel magnetic nanoparticles hyperthermia self-regulating temperature; biocompatibility |
| url | http://dx.doi.org/10.1080/02656736.2020.1863479 |
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