Effects of cortisol on retrieval of extinction memory in individuals with social anxiety
While exposure-based treatment for social anxiety disorder (SAD) has been shown to be effective, the high relapse rate remains a problem. Although relapse has been understood as the inability to retrieve extinction memory, the factors that influence the extent of retrieval of extinction memory have...
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| Format: | Article |
| Language: | English |
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Elsevier
2021-08-01
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| Series: | Comprehensive Psychoneuroendocrinology |
| Subjects: | |
| Online Access: | http://www.sciencedirect.com/science/article/pii/S2666497621000345 |
| _version_ | 1818922622724866048 |
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| author | Chihiro Moriishi Maeda Shunta Hiroyoshi Ogishima Hironori Shimada |
| author_facet | Chihiro Moriishi Maeda Shunta Hiroyoshi Ogishima Hironori Shimada |
| author_sort | Chihiro Moriishi |
| collection | DOAJ |
| description | While exposure-based treatment for social anxiety disorder (SAD) has been shown to be effective, the high relapse rate remains a problem. Although relapse has been understood as the inability to retrieve extinction memory, the factors that influence the extent of retrieval of extinction memory have not been determined. This study aimed to examine whether the cortisol response to acute stressors in socially anxious individuals inhibits the retrieval of extinction memory, focusing on the cortisol response to acute stressors as a factor. Thirty-nine participants who scored 42 or more on the Liebowitz Social Anxiety Scale participated in the experiment for two consecutive days. On the first day, a fear conditioning task aimed at learning fear and extinction memory was administered, and on the second day, a psychosocial stress task (Trier Social Stress Test; TSST) was conducted, followed by an extinction retrieval test. The results indicated that cortisol responsiveness (Responder/Non-responder) was not associated with the retrieval of extinction memory indexed by subjective and physiological measures. However, a supplementary analysis revealed that the total amount of cortisol secretion was associated with attenuated retrieval of extinction memory. These findings suggest that the total cortisol secretions, rather than cortisol responsiveness to the acute stressor, may play a role in relapse. |
| first_indexed | 2024-12-20T01:56:28Z |
| format | Article |
| id | doaj.art-f15d737577b040698b246f39057f2bf4 |
| institution | Directory Open Access Journal |
| issn | 2666-4976 |
| language | English |
| last_indexed | 2024-12-20T01:56:28Z |
| publishDate | 2021-08-01 |
| publisher | Elsevier |
| record_format | Article |
| series | Comprehensive Psychoneuroendocrinology |
| spelling | doaj.art-f15d737577b040698b246f39057f2bf42022-12-21T19:57:29ZengElsevierComprehensive Psychoneuroendocrinology2666-49762021-08-017100060Effects of cortisol on retrieval of extinction memory in individuals with social anxietyChihiro Moriishi0Maeda Shunta1Hiroyoshi Ogishima2Hironori Shimada3Graduate School of Human Sciences, Waseda University, 15-579-2 Mikajima, Tokorozawa, Saitama, 359-1192, Japan; Corresponding author.Graduate School of Education, Tohoku University, 1-27 Kawauchi, Aoba-ku, Sendai, Miyagi, 980-8576, JapanResearch Center for Future Design, Kochi University of Technology, 22-2 Eikokuji-cho, Kochi, Kochi, 780-8515, JapanFaculty of Human Sciences, Waseda University, 15-579-2 Mikajima, Tokorozawa, Saitama, 359-1192, JapanWhile exposure-based treatment for social anxiety disorder (SAD) has been shown to be effective, the high relapse rate remains a problem. Although relapse has been understood as the inability to retrieve extinction memory, the factors that influence the extent of retrieval of extinction memory have not been determined. This study aimed to examine whether the cortisol response to acute stressors in socially anxious individuals inhibits the retrieval of extinction memory, focusing on the cortisol response to acute stressors as a factor. Thirty-nine participants who scored 42 or more on the Liebowitz Social Anxiety Scale participated in the experiment for two consecutive days. On the first day, a fear conditioning task aimed at learning fear and extinction memory was administered, and on the second day, a psychosocial stress task (Trier Social Stress Test; TSST) was conducted, followed by an extinction retrieval test. The results indicated that cortisol responsiveness (Responder/Non-responder) was not associated with the retrieval of extinction memory indexed by subjective and physiological measures. However, a supplementary analysis revealed that the total amount of cortisol secretion was associated with attenuated retrieval of extinction memory. These findings suggest that the total cortisol secretions, rather than cortisol responsiveness to the acute stressor, may play a role in relapse.http://www.sciencedirect.com/science/article/pii/S2666497621000345CortisolRelapseExtinction memorySocial anxiety |
| spellingShingle | Chihiro Moriishi Maeda Shunta Hiroyoshi Ogishima Hironori Shimada Effects of cortisol on retrieval of extinction memory in individuals with social anxiety Comprehensive Psychoneuroendocrinology Cortisol Relapse Extinction memory Social anxiety |
| title | Effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| title_full | Effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| title_fullStr | Effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| title_full_unstemmed | Effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| title_short | Effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| title_sort | effects of cortisol on retrieval of extinction memory in individuals with social anxiety |
| topic | Cortisol Relapse Extinction memory Social anxiety |
| url | http://www.sciencedirect.com/science/article/pii/S2666497621000345 |
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